Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Britta George"'
Autor:
Mee-Ling Maywald, Cara Picciotto, Carolin Lepa, Luisa Bertgen, Farwah Sanam Yousaf, Andrea Ricker, Jürgen Klingauf, Michael P. Krahn, Hermann Pavenstädt, Britta George
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinu
Externí odkaz:
https://doaj.org/article/32575005d58b41b7b31f31d5282e4d08
Autor:
Ulrich Jehn, Cornelie Müller-Hofstede, Barbara Heitplatz, Veerle Van Marck, Stefan Reuter, Hermann Pavenstädt, Britta George
Publikováno v:
Case Reports in Nephrology, Vol 2022 (2022)
Background. Alport syndrome results from a hereditary defect of collagen IV synthesis. This causes progressive glomerular disease, ocular abnormalities, and inner ear impairment. Case Presentation. Herein, we present a case of Alport syndrome in a 28
Externí odkaz:
https://doaj.org/article/184fdd2baf6849c285c4474d96a425d1
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies
Autor:
Annika Möller-Kerutt, Birgit Schönhoff, Yvonne Rellmann, Britta George, Daniela Anne Braun, Hermann Pavenstädt, Thomas Weide
Publikováno v:
Life science alliance. 6(3)
Crumbs2 (CRB2) is a central component of the renal filtration barrier and part of the slit diaphragm, a unique cell contact formed by glomerular podocytes. SomeCRB2variants cause recessive inherited forms of steroid-resistant nephrotic syndrome. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49178ff4ed23c560f97ae6b9eb9f67b8
https://pubmed.ncbi.nlm.nih.gov/36549870
https://pubmed.ncbi.nlm.nih.gov/36549870
Autor:
Roland Wedlich-Söldner, Carolin Lepa, Britta George, Veerle Van Marck, Malte Krakow, Mee-Ling Eddy, Jürgen Klingauf, Michael P. Krahn, Antje Stöber, Thomas Weide, Andrea Ricker, Christian Klämbt, Hermann Pavenstädt, Astrid Jeibmann, Cara Picciotto, Christopher P Dlugos
Publikováno v:
Journal of the American Society of Nephrology. 30:1006-1019
Background Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571cd21f6d6cdb7e4077e9305f94071d
https://doi.org/10.1681/asn.2018040362
https://doi.org/10.1681/asn.2018040362
Autor:
Ulf Schulze, Jakob Bonse, Michael P. Krahn, Britta George, Jochen Seggewiß, Hermann Pavenstädt, Olga Panichkina, Christoph Daniel, Wilhelm Kriz, Florian Hochapfel, Kerstin Amann, Seonhee Kim, Dirk-Oliver Wennmann, Ivona Djuric, Beate Vollenbröker, Maria Edeling, Thomas Weide
Publikováno v:
Journal of the American Society of Nephrology. 28:2093-2107
The nephron is the basic physiologic subunit of the mammalian kidney and is made up of several apicobasally polarized epithelial cell types. The process of apicobasal polarization in animal cells is controlled by the evolutionarily conserved Crumbs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8ce125c7100741e8167da9022f1d3b
https://doi.org/10.1681/asn.2016040474
https://doi.org/10.1681/asn.2016040474
Autor:
Cara Picciotto, Miriam Stölting, Elke Butt, Dontscho Kerjaschki, Britta George, Beate Vollenbröker, Mee-Ling Eddy, Adelheid Korb-Pap, Carolin Lepa, Thomas Weide, Annika Möller-Kerutt, Joachim Kremerskothen, Hermann Pavenstädt
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(4)
The foot processes of podocytes exhibit a dynamic actin cytoskeleton, which maintains their complex cell structure and antagonizes the elastic forces of the glomerular capillary. Interdigitating secondary foot processes form a highly selective filter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c359f322e2959784563f45ea3bd83cc7
https://pubmed.ncbi.nlm.nih.gov/32086849
https://pubmed.ncbi.nlm.nih.gov/32086849
Autor:
Christopher Philipp, Dlugos, Cara, Picciotto, Carolin, Lepa, Malte, Krakow, Antje, Stöber, Mee-Ling, Eddy, Thomas, Weide, Astrid, Jeibmann, Michael, P Krahn, Veerle, Van Marck, Jürgen, Klingauf, Andrea, Ricker, Roland, Wedlich-Söldner, Hermann, Pavenstädt, Christian, Klämbt, Britta, George
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0ace7b7fc554e584ba10bad89d090e1
https://pubmed.ncbi.nlm.nih.gov/31097607
https://pubmed.ncbi.nlm.nih.gov/31097607
Autor:
Thomas Weide, Sascha Gromnitza, Carolin Lepa, Albrecht Schwab, Hermann Pavenstädt, Britta George
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(3)
Podocyte malfunction is central to glomerular diseases and is marked by defective podocyte intercellular junctions and actin cytoskeletal dynamics. Podocytes share many morphologic features with neurons, so that similar sets of proteins appear to reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a64655a5b2b048767b9966660eea9f6
https://pubmed.ncbi.nlm.nih.gov/29162704
https://pubmed.ncbi.nlm.nih.gov/29162704
Autor:
Abdul Soofi, Lawrence B. Holzman, Tom Curran, Qingfeng Fan, Christopher P. Dlugos, Rakesh Verma, Tae-Ju Park, Britta George, Hetty N. Wong, Deepak Nihalani, Jidong Zhang
Publikováno v:
Kidney international
Activation of the slit diaphragm protein nephrin induces actin cytoskeletal remodeling, resulting in lamellipodia formation in podocytes in vitro in a phosphatidylinositol-3 kinase-, focal adhesion kinase-, Cas-, and Crk1/2-dependent fashion. In mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4c96e0d4a4b2d6f9793f811646b5e0
https://doi.org/10.1038/ki.2013.556
https://doi.org/10.1038/ki.2013.556
Autor:
Lawrence B. Holzman, Britta George
Publikováno v:
Seminars in Nephrology. 32:307-318
Observations of hereditary glomerular disease support the contention that podocyte intercellular junction proteins are essential for junction formation and maintenance. Genetic deletion of most of these podocyte intercellular junction proteins result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f628471669d4ea21aa7335de39f4804
https://doi.org/10.1016/j.semnephrol.2012.06.002
https://doi.org/10.1016/j.semnephrol.2012.06.002