Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Britt A Glaunsinger"'
Autor:
Chloe O McCollum, Allison L Didychuk, Dawei Liu, Laura A Murray-Nerger, Ileana M Cristea, Britt A Glaunsinger
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011163 (2023)
β- and γ-herpesviruses transcribe their late genes in a manner distinct from host transcription. This process is directed by a complex of viral transcriptional activator proteins that hijack cellular RNA polymerase II and an unknown set of addition
Externí odkaz:
https://doaj.org/article/525b2634a9294d85b169d15bd253d80b
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010099 (2022)
The mRNA 5' cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly regul
Externí odkaz:
https://doaj.org/article/58f67aa922ba4ece9d0054a02ca771dc
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010236 (2022)
While traditional methods for studying large DNA viruses allow the creation of individual mutants, CRISPR/Cas9 can be used to rapidly create thousands of mutant dsDNA viruses in parallel, enabling the pooled screening of entire viral genomes. Here, w
Externí odkaz:
https://doaj.org/article/1ba31f7a603c449ebb7b9eb2917ecefc
Publikováno v:
eLife, Vol 10 (2021)
RNA abundance is generally sensitive to perturbations in decay and synthesis rates, but crosstalk between RNA polymerase II transcription and cytoplasmic mRNA degradation often leads to compensatory changes in gene expression. Here, we reveal that wi
Externí odkaz:
https://doaj.org/article/3f9a43cc4bbf4a76a6986258e5c17924
Autor:
Allison L Didychuk, Stephanie N Gates, Matthew R Gardner, Lisa M Strong, Andreas Martin, Britt A Glaunsinger
Publikováno v:
eLife, Vol 10 (2021)
Genome packaging in large double-stranded DNA viruses requires a powerful molecular motor to force the viral genome into nascent capsids, which involves essential accessory factors that are poorly understood. Here, we present structures of two such a
Externí odkaz:
https://doaj.org/article/15f852b90be240649007f66750a4e52d
Autor:
Angelica F Castañeda, Allison L Didychuk, Robert K Louder, Chloe O McCollum, Zoe H Davis, Eva Nogales, Britt A Glaunsinger
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008843 (2020)
β- and γ-herpesviruses include the oncogenic human viruses Kaposi's sarcoma-associated virus (KSHV) and Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV), which is a significant cause of congenital disease. Near the end of their replicatio
Externí odkaz:
https://doaj.org/article/005cb66f0d454bafb9f9437a2c7aa7ab
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008269 (2020)
In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including K
Externí odkaz:
https://doaj.org/article/600e6ad49fe84be3b8ad2b603c0c623d
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006995 (2018)
Methylation at the N6 position of adenosine (m6A) is a highly prevalent and reversible modification within eukaryotic mRNAs that has been linked to many stages of RNA processing and fate. Recent studies suggest that m6A deposition and proteins involv
Externí odkaz:
https://doaj.org/article/f46fe3a781c1481c8219d32948e3da13
Autor:
Mandy Muller, Britt A Glaunsinger
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006593 (2017)
During lytic Kaposi's sarcoma-associated herpesvirus (KSHV) infection, the viral endonu- clease SOX promotes widespread degradation of cytoplasmic messenger RNA (mRNA). However, select mRNAs, including the transcript encoding interleukin-6 (IL-6), es
Externí odkaz:
https://doaj.org/article/72b9eefc7ea848d2b842945000d019df
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005305 (2015)
Many viruses express factors that reduce host gene expression through widespread degradation of cellular mRNA. An example of this class of proteins is the mRNA-targeting endoribonuclease SOX from the gamma-herpesvirus Kaposi's sarcoma-associated herp
Externí odkaz:
https://doaj.org/article/30efd3fb3f0b46ae8c4242aff30a76e0