Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Brit B. Sørensen"'
Autor:
Jens Buchardt, Heidi L. Holmberg, Johan Karlsson, Mads Kjelgaard-Hansen, Kasper Lamberth, Anders B. Sorensen, Wolfram Ruf, Prafull S. Gandhi, Carsten Dan Ley, Brit B. Sørensen, Anders Lærke Nielsen, Henrik Østergaard, Ole Hvilsted Olsen
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12454-12459
Recombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the treatment of bleeding episodes in patients with inhibitor-complicated hemophilia. Here, an approach was adopted to enhance the activity of FVIIa by sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf0681d039e3e21fd96e4f18b164330
https://doi.org/10.1073/pnas.1618713114
https://doi.org/10.1073/pnas.1618713114
Publikováno v:
Haemophilia. 23:769-776
Aims Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor (TFPI), is being developed as a subcutaneously (s.c.) administered treatment for haemophilia. It demonstrated a concentration-dependent procoagulant effect in fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b85fbf14d6f30bc9d2eff1dd4b9b5c
https://doi.org/10.1111/hae.13260
https://doi.org/10.1111/hae.13260
Publikováno v:
Journal of Thrombosis and Haemostasis. 13:2041-2052
SummaryBackground Conventional coagulation factor assays are associated with certain limitations, as they do not always reflect the clinical heterogeneity of bleeding in hemophilic patients or correctly reflect the individual patient response to trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950be16764c7a4d25f7ed69278b04978
https://doi.org/10.1111/jth.13134
https://doi.org/10.1111/jth.13134
Autor:
B. Hua, L. Wang, Tina Manon-Jensen, Brit B. Sørensen, Eva H. N. Olsen, Kirstine Roepstorff, Yupei Zhao, Morten A. Karsdal, S. Sun, Mads Kjelgaard-Hansen, B. Vandahl, C. N. Gudme
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 23(4)
Introduction Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. Aim We investigated whether biomarkers of cartilage and bone degradation, and inflammation were altered in haemophilia patients and whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c536e7c3ad176cf6d4da23470a23aca4
https://pubmed.ncbi.nlm.nih.gov/28439941
https://pubmed.ncbi.nlm.nih.gov/28439941
Autor:
Berit Olsen Krogh, Brit B. Sørensen, L. Anders Svensson, Mirella Ezban, Kristoffer W. Balling, Jens Breinholt, Helle Heibroch Petersen, Jes Thorn Clausen, Lene Hansen, Christina Jespersgaard, Birgitte Friederichsen, Albrecht Gruhler, Andrew Neil Bowler, Brian Lauritzen, Lars Christian Petersen, Søren E. Bjørn, Thomas Egebjerg, Mette B. Hermit, Ida Hilden
Publikováno v:
Blood. 119:5871-5878
Hemophilia is treated by IV replacement therapy with Factor VIII (FVIII) or Factor IX (FIX), either on demand to resolve bleeding, or as prophylaxis. Improved treatment may be provided by drugs designed for subcutaneous and less frequent administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b3cf7ab4b2f5e1d4080a2981c247ec
https://doi.org/10.1182/blood-2012-01-401620
https://doi.org/10.1182/blood-2012-01-401620
Autor:
Mirella Ezban, S. Segel, Thomas Dock Steenstrup, A. Bagger-Sørensen, Egon Persson, Stefan Lethagen, Niels Kristian Klausen, Ida Hilden, M. L. S. Christiansen, Dorthe Viuff, Brit B. Sørensen, Kristoffer W. Balling, Marianne Kjalke
Publikováno v:
Haemophilia. 16:878-887
The aim of this study was to evaluate the in vitro function of the new recombinant factor VIII (FVIII) compound, N8. The specific activity of N8 as measured in a FVIII:C one-stage clot assay was 9300±400 IU mg(-1) based on the analysis of seven indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe20fe7b346713b1960e4e536e062ab
https://doi.org/10.1111/j.1365-2516.2010.02333.x
https://doi.org/10.1111/j.1365-2516.2010.02333.x
Autor:
Mette B. Hermit, Henrik Agersø, Mikael Tranholm, Inger Thorup, Brit B. Sørensen, Mirella Ezban, Henning R. Stennicke, Peter B. Johansen, Søren E. Bjørn
Publikováno v:
Thrombosis and Haemostasis. 104:157-164
SummaryThe pharmacokinetics and pharmacodynamics of 40k-PEG-rFVIIa, a GlycoPEGylated derivative of recombinant wild-type FVIIa, were compared with rFVIIa in rabbits. The procoagulant effect was determined as the weight of the clot formed in a defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee203d12d8fee4b1d344f1588763a1e6
https://doi.org/10.1160/th09-11-0797
https://doi.org/10.1160/th09-11-0797
Autor:
Mirella Ezban, Ditte M. Karpf, Brit B. Sørensen, Torben Elm, Anne Steinø, Eva H. N. Olsen, Lars Christian Petersen, Thomas N. Krogh
Publikováno v:
Thrombosis and Haemostasis. 101:818-826
SummaryThe mechanism for the elimination of factor VII (FVII) from the circulation is unknown, just as it is unclear how activation of FVII to FVIIa and subsequent complex formation with antithrombin III (AT) or α2-macroglobulin (α2M) affects clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4615cb4690799a1cc891d80fea911346
https://doi.org/10.1160/th08-10-0699
https://doi.org/10.1160/th08-10-0699
Autor:
Brit B. Sørensen, Robert Bayer, David Zopf, Kyle Kinealy, Matt S. Kalo, Søren E. Bjørn, Henrik Østergaard, Pernille Holm, Henning R. Stennicke
Publikováno v:
Thrombosis and Haemostasis. 100:920-928
SummaryProphylaxis with 2–4 times weekly dosing of factor (F)VIII or FIX is established as an efficacious and safe treatment in haemophilia. Although prophylaxis is not readily available for the inhibitor patient,recent studies have demonstrated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0e6d5163984655ae3c8bb8bd505969
https://doi.org/10.1160/th08-04-0268
https://doi.org/10.1160/th08-04-0268
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:P-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89654df193e37b3847eaf9a380620194
https://doi.org/10.1111/j.1538-7836.2007.tb01773.x
https://doi.org/10.1111/j.1538-7836.2007.tb01773.x