Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Briony L Gliddon"'
Autor:
Jake Nowicki, Michael P Brown, Tessa Gargett, Lisa M Ebert, Nga T H Truong, Paris M Kollis, Kristyna Sedivakova, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Briony L Gliddon, Melinda N Tea, Rebecca Ormsby, Santosh Poonnoose, Orazio Vittorio, David S Ziegler, Stuart M Pitson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited,
Externí odkaz:
https://doaj.org/article/aeb6b5a8c73041bf87654aafeab489d5
Autor:
Melissa K. Bennett, Manjun Li, Melinda N. Tea, Melissa R. Pitman, John Toubia, Paul P.-S. Wang, Dovile Anderson, Darren J. Creek, Robert Z. Orlowski, Briony L. Gliddon, Jason A. Powell, Craig T. Wallington-Beddoe, Stuart M. Pitson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 1-11 (2022)
The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients, this haematological mal
Externí odkaz:
https://doaj.org/article/f5e0bdd9d3004cfdbf70bbe296a47fe3
Autor:
Stuart M. Pitson, Melissa R. Pitman, Martin K. Oehler, Paul A.B. Moretti, Houng Taing, Briony L. Gliddon, Lorena T. Davies, Heidi A. Neubauer, Noor A. Lokman, Kate E. Jarman, Wenying Zhu
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which is mediated by the calcium and integrin bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::278a9e2d88d7cea9780c615b9658073a
https://doi.org/10.1158/0008-5472.c.6509058.v1
https://doi.org/10.1158/0008-5472.c.6509058.v1
Autor:
Stuart M. Pitson, Melissa R. Pitman, Martin K. Oehler, Paul A.B. Moretti, Houng Taing, Briony L. Gliddon, Lorena T. Davies, Heidi A. Neubauer, Noor A. Lokman, Kate E. Jarman, Wenying Zhu
Supplementary Methods. Supplementary Figure S1. Validation of the physiological interaction between CIB2 and SK1 using proximity ligation assays with different antibody combinations. Supplementary Figure S2. N-myristoylation of CIB2 does not affect i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc99d8061f2dc35a1edcc58b7d0b27e8
https://doi.org/10.1158/0008-5472.22414710.v1
https://doi.org/10.1158/0008-5472.22414710.v1
Autor:
Briony L. Gliddon, Craig T. Wallington-Beddoe, Manjun Li, Darren J. Creek, Melissa R. Pitman, Melinda N. Tea, Paul Wang, Dovile Anderson, John Toubia, Melissa K. Bennett, Robert Z. Orlowski, Stuart M. Pitson, Jason A. Powell
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 1-11 (2022)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Refereed/Peer-reviewed The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4372e540234dd54ec39b9af964b760
http://www.sciencedirect.com/science/article/pii/S1476558621000993
http://www.sciencedirect.com/science/article/pii/S1476558621000993
Autor:
Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid leukemia (AML) cells by inhibition of sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed8fbe2daf653ebbee791ab6b83276b
https://hdl.handle.net/11541.2/31406
https://hdl.handle.net/11541.2/31406
Autor:
Tessa Gargett, Lisa M Ebert, Nga T H Truong, Paris M Kollis, Kristyna Sedivakova, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Briony L Gliddon, Melinda N Tea, Rebecca Ormsby, Santosh Poonnoose, Jake Nowicki, Orazio Vittorio, David S Ziegler, Stuart M Pitson, Michael P Brown
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e005187
BackgroundAggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db02d9834284e5bfabdf812eeafd4f68
https://doi.org/10.1136/jitc-2022-005187
https://doi.org/10.1136/jitc-2022-005187
Autor:
Alpha S. Yap, Benjamin M. Hogan, Stuart M. Pitson, Briony L. Gliddon, Guillermo A. Gomez, Anne K. Lagendijk, Mei-Kwan Yau, Robert G. Parton, Suzie Verma, Thomas E. Hall, Kinga Duszyc, David P. Fairlie
Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation [1]. Several different mechanisms exist for apoptotic clearance, including efferocytosis [2, 3] and apical extrusion [4, 5]. We found that extrusion was the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22f803025034fc2222cbfb8226ef52e
https://doi.org/10.1101/2020.08.06.240671
https://doi.org/10.1101/2020.08.06.240671
Autor:
David P. Fairlie, Briony L. Gliddon, Suzie Verma, Bageshri Naimish Nanavati, Benjamin M. Hogan, Alpha S. Yap, Thomas E. Hall, Guillermo A. Gomez, Mei-Kwan Yau, Stuart M. Pitson, Anne K. Lagendijk, Robert G. Parton, Kinga Duszyc
Publikováno v:
Current biology : CB. 31(6)
Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation.1 Several different mechanisms exist for apoptotic clearance, including efferocytosis2,3 and apical extrusion.4,5 We found that extrusion was the first-line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d463517da7a60db213a53a4f5272ff7
https://pubmed.ncbi.nlm.nih.gov/33581074
https://pubmed.ncbi.nlm.nih.gov/33581074
Autor:
Cassandra Stefanidis, Claudine S. Bonder, Briony L. Gliddon, Maurizio Costabile, Melinda N. Tea, Melissa R. Pitman, Julia R. Zebol, Paul A.B. Moretti, Heidi A. Neubauer, Brett W. Stringer, Bryan W. Day, Stuart M. Pitson, Jason A. Powell, Jasreen Kular, Michael S. Samuel
Publikováno v:
Oncogene
While the two mammalian sphingosine kinases, SK1 and SK2, both catalyze the generation of pro-survival sphingosine 1-phosphate (S1P), their roles vary dependent on their different subcellular localization. SK1 is generally found in the cytoplasm or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f1bf6cabe74c5c92b2081d06f30713
https://hdl.handle.net/11541.2/134345
https://hdl.handle.net/11541.2/134345