Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress

Autor: González-Amor M, García-Redondo AB, Jorge I, Zalba G, Becares M, Ruiz-Rodríguez MJ, Rodríguez C, Bermeo H, Rodrigues-Díez R, Rios FJ, Montezano AC, Martínez-González J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM

Publikováno v: CARDIOVASCULAR RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

AIMS: Interferon-stimulated gene 15 (ISG15) encodes an ubiquitin-like protein that induces a reversible post-translational modification (ISGylation) and can also be secreted as a free form. ISG15 plays an essential role as host-defense response to mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b0224fc3ccc03435ad79700e26c73d55
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7967

Carnitine palmitoyltransferase-1 up-regulation by PPAR-ß/d prevents lipid-induced endothelial dysfunction

Autor: Toral M, Romero M, Jiménez R, Mahmoud AM, Barroso E, Gómez-Guzmán M, Sánchez M, Cogolludo Á, García-Redondo AB, Briones AM, Vazquez M, Pérez-Vizcaíno F, Duarte J

Publikováno v: CLIN SCI
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Fatty acids cause endothelial dysfunction involving increased ROS (reactive oxygen species) and reduced NO (nitric oxide) bioavailability. We show that in MAECs (mouse aortic endothelial cells), the PPARß/d (peroxisome- proliferator-activated recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a891f6d0010e25c125f9d81828dc4a7
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11996

Lysyl oxidase (LOX) in vascular remodelling

Autor: Orriols, M, Guadall, A, Galan, M, Marti-Pamies, I, Varona, S, Rodriguez-Calvo, R, Briones, AM, Navarro, MA, de Diego, A, Osada, J, Martinez-Gonzalez, J, Rodriguez, C

Publikováno v: THROMBOSIS AND HAEMOSTASIS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::c7f9a6084af9ad6fb152ce2287dbc538
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9135

PPAR¿ activation improves oxidative stress and downregulates COX-2 expression in vascular cells

Autor: Palacios, R, Pérez-Girón, JV, Martín, A, Hernanz, R, Briones, AM, Salaices, M, Alonso, MJ

Publikováno v: BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname

Introduction: The increased renin-angiotensin system (RAS) activity seems to contribute to the pathophysiology of hypertension by the increase in reactive oxygen species (ROS) levels and proinflammatory mediators. Endothelin-1 (ET-1) has been propose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::855ed29ee85ce9f336f1213ce621686c
http://hdl.handle.net/10115/3306

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