Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Brinkkoetter P"'
Autor:
Christoph Heinrich Lindemann, Volker Burst, Linus Alexander Völker, Sebastian Brähler, Dusan Simic, Ingrid Becker, Martin Hellmich, Clarissa Kurscheid, Nadine Scholten, Ruben Krauspe, Kerstin Leibel, Stephanie Stock, Paul Thomas Brinkkoetter
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Multimorbid and frail elderly patients often carry a high burden of treatment. Hospitalization due to the onset of an acute illness can disrupt the fragile balance, resulting in further readmissions after hospital discharge. Curre
Externí odkaz:
https://doaj.org/article/c2401324bee049acb84435891d279151
Autor:
Thomas Schömig, Paul Diefenhardt, Ingo Plagmann, Bastian Trinsch, Tim Merz, Giuliano Crispatzu, David Unnersjö-Jess, Jasper Nies, David Pütz, Claudio Sierra Gonzalez, Bernhard Schermer, Thomas Benzing, Paul Thomas Brinkkoetter, Sebastian Brähler
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Podocytes form the kidney filtration barrier and continuously adjust to external stimuli to preserve their integrity even in the presence of inflammation. It was suggested that canonical toll-like receptor signaling, mediated by the adaptor
Externí odkaz:
https://doaj.org/article/9876ddb5e0934f8d8f9d9a648f58c3d3
Autor:
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109749- (2024)
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i
Externí odkaz:
https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15
Autor:
Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen, Beata Samelko, Mehmet M. Altintas, Yashwanth R. Sudhini, Xuexiang Wang, Richard Bouley, Dennis Brown, Bradley P. Pedro, Susan L. Bane, Vineet Gupta, Paul T. Brinkkoetter, Henning Hagmann, Jochen Reiser, Sanja Sever
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in
Externí odkaz:
https://doaj.org/article/de985803365d4a178cb549392c2a5749
Autor:
Kühne, Lucas, Knöbl, Paul, Eller, Kathrin, Thaler, Johannes, Sperr, Wolfgang R., Gleixner, Karoline, Osterholt, Thomas, Kaufeld, Jessica, Menne, Jan, Buxhofer-Ausch, Veronika, Mühlfeld, Anja, Seelow, Evelyn, Schreiber, Adrian, Todorova, Polina, Cukoski, Sadrija, Jabs, Wolfram J., Özcan, Fedai, Gäckler, Anja, Schönfelder, Kristina, Seibert, Felix S., Westhoff, Timm, Schwenger, Vedat, Eichenauer, Dennis A., Völker, Linus A., Brinkkoetter, Paul T., Albert, Annemarie, Bramstedt, Jörn, Brand, Marcus, Brinkkötter, Paul T., Cukoski, Sadrija, Eichenauer, Dennis A., Elitok, Saban, Felten, Helmut, Gäckler, Anja, Geuther, Gesa, Harth, Ana, Hausberg, Martin, Hermann, Matthias, Hinkel, Ulrich P., Jabs, Wolfram Johannes, Kaufeld, Jessica, Klein, Gilles, Klemm, Kristin, Kolbrink, Benedikt, Kühne, Lucas, Menne, Jan, Miesbach, Wolfgang, Mühlfeld, Anja Susanne, Özcan, Fedai, Osterholt, Thomas, Pfrepper, Christian, Potthoff, Sebastian A., Radermacher, Jörg, Ruhe, Johannes, Schmidt, Tilman, Schönermarck, Ulf, Schönfelder, Kristina, Schreiber, Adrian, Schulte, Kevin, Schulte-Kemna, Lena, Schwenger, Vedat, Seelow, Evelyn, Seibert, Felix S., Todorova, Polina, Tölle - Charité, Markus, Völker, Linus A., Walendy, Victor, Wendt, Ralph, Westhoff, Timm H.
Publikováno v:
Blood; October 2024, Vol. 144 Issue: 14 p1486-1495, 10p
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract Background Plasma cell dyscrasias (PCD) are characterized by an abnormal production of intact monoclonal immunoglobulins or parts such as heavy or light chains. In most cases, the monoclonal protein (also termed paraprotein) is produced by a
Externí odkaz:
https://doaj.org/article/82fc201f84154be4ab617acae09c663f
Autor:
Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Mahsa Matin, Cem Oezel, He Chen, Astrid Schauss, Christoph Schell, Thomas Benzing, Stuart Dryer, Paul T. Brinkkoetter
Publikováno v:
Cells, Vol 12, Iss 2, p 271 (2023)
Reactive oxygen species (ROS), which excessively arise in diabetes and systemic inflammatory diseases, modify cellular lipids and cellular lipid composition leading to altered biophysical properties of cellular membranes. The impact of lipid peroxida
Externí odkaz:
https://doaj.org/article/2d7bdc0e63994f23875a456f5d296c02
Autor:
Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Cem Oezel, Antonios Papadakis, Alexander Kuczkowski, Thomas Benzing, Erich Gulbins, Stuart Dryer, Paul T. Brinkkoetter
Publikováno v:
Cells, Vol 11, Iss 22, p 3625 (2022)
Diabetes and inflammatory diseases are associated with an altered cellular lipid composition due to lipid peroxidation. The pathogenic potential of these lipid alterations in glomerular kidney diseases remains largely obscure as suitable cell culture
Externí odkaz:
https://doaj.org/article/98e33ae72fdb479e90b935ddbc2a812f
Autor:
Nicole Mangold, Jeffrey Pippin, David Unnersjoe-Jess, Sybille Koehler, Stuart Shankland, Sebastian Brähler, Bernhard Schermer, Thomas Benzing, Paul T. Brinkkoetter, Henning Hagmann
Publikováno v:
Cells, Vol 10, Iss 9, p 2464 (2021)
Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type a
Externí odkaz:
https://doaj.org/article/a54a1550dd394d05bc239bd08365d0cf
Autor:
Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1551-1566.e5 (2019)
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of g
Externí odkaz:
https://doaj.org/article/797ae05543d74f758e692293a53995ac