Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

Autor: Brima Musa Younis, Ahmed Mudawi Musa, Séverine Monnerat, Mohammed Abdelrahim Saeed, Eltahir Awad Gasim Khalil, Anas Elbashir Ahmed, Mujahid Ahmed Ali, Ali Noureldin, Gina Muthoni Ouattara, Godfrey M Nyakaya, Samuel Teshome, Truphosa Omollo, Michael Ochieng, Thaddaeus Egondi, Mildred Mmbone, Wan-Yu Chu, Thomas P C Dorlo, Eduard E Zijlstra, Monique Wasunna, Jorge Alvar, Fabiana Alves

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011780 (2023)

BackgroundTreatment for post-kala-azar dermal leishmaniasis (PKDL) in Sudan is currently recommended only for patients with persistent or severe disease, mainly because of the limitations of current therapies, namely toxicity and long hospitalization

Externí odkaz: https://doaj.org/article/8e80fbd2c0f14737b661e76f2ce1ecf5

Sodium stibogluconate (SSG) & paromomycin combination compared to SSG for visceral leishmaniasis in East Africa: a randomised controlled trial.

Autor: Ahmed Musa, Eltahir Khalil, Asrat Hailu, Joseph Olobo, Manica Balasegaram, Raymond Omollo, Tansy Edwards, Juma Rashid, Jane Mbui, Brima Musa, Abuzaid Abdalla Abuzaid, Osama Ahmed, Ahmed Fadlalla, Ahmed El-Hassan, Marius Mueller, Geoffrey Mucee, Simon Njoroge, Veronica Manduku, Geoffrey Mutuma, Lilian Apadet, Hudson Lodenyo, Dedan Mutea, George Kirigi, Sisay Yifru, Getahun Mengistu, Zewdu Hurissa, Workagegnehu Hailu, Teklu Weldegebreal, Hailemariam Tafes, Yalemtsehay Mekonnen, Eyasu Makonnen, Serah Ndegwa, Patrick Sagaki, Robert Kimutai, Josephine Kesusu, Rhoda Owiti, Sally Ellis, Monique Wasunna

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1674 (2012)

Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious for VL treatment in India.A multi-centre randomized-controlled trial (RCT) to compare efficacy and safety o

Externí odkaz: https://doaj.org/article/43f9bae862404e6cb8fcfe11b1ee9d29

Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

Autor: Younis, Brima Musa¹ (AUTHOR), Mudawi Musa, Ahmed¹ (AUTHOR), Monnerat, Séverine² (AUTHOR), Abdelrahim Saeed, Mohammed¹ (AUTHOR), Awad Gasim Khalil, Eltahir¹ (AUTHOR), Elbashir Ahmed, Anas¹ (AUTHOR), Ahmed Ali, Mujahid¹ (AUTHOR), Noureldin, Ali¹ (AUTHOR), Muthoni Ouattara, Gina³ (AUTHOR), Nyakaya, Godfrey M.³ (AUTHOR), Teshome, Samuel³ (AUTHOR), Omollo, Truphosa³ (AUTHOR), Ochieng, Michael³ (AUTHOR), Egondi, Thaddaeus³ (AUTHOR), Mmbone, Mildred³ (AUTHOR), Chu, Wan-Yu⁴ (AUTHOR), Dorlo, Thomas P. C.⁵ (AUTHOR), Zijlstra, Eduard E.² (AUTHOR), Wasunna, Monique³ (AUTHOR), Alvar, Jorge² (AUTHOR)

Publikováno v: PLoS Neglected Tropical Diseases. 11/21/2023, Vol. 17 Issue 11, p1-20. 20p.

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Leishmania donovani-Induced Immune Dysregulation among Sudanese Patients with Visceral and Post Kala-Azar Dermal Leishmaniases: Possible Roles in Pathogenesis

Autor: Eltahir A G Khalil, Brima Musa, Ahmed Mudawi Mudawi, M. E. E. Elfaki, Elsamani Elmotwafig Mohamed Elsammani

Publikováno v: Advances in Infectious Diseases. 10:235-242

L. donovani infections (visceral and post kala-azar dermal leishmaniases) are characterized by infection-induced reversible immune suppression. Autoimmunity is a well-documented phenomenon among patients with primary immune deficiencies. This study a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b09c02bdba9c0c246cb11fbf7d41059d
https://doi.org/10.4236/aid.2020.105021