Targeted retreatment of incompletely recovered COPD exacerbations with ciprofloxacin: a double-blind, randomised, placebo-controlled, multicentre phase III trial

Autor: Ritchie, AI, Brill, SE, Vlies, BH, Finney, LJ, Allinson, JP, Alves-Moreira, L, Wiseman, DJ, Walker, PP, Baker, E, Elkin, SL, Mallia, P, Law, M, Donaldson, GC, Calverley, PMA, Wedzicha, JA

RATIONALE: COPD exacerbations are prone to non-recovery but there are no data about the effectiveness of retreatment on these prolonged events. We examined whether further therapy with ciprofloxacin for incompletely resolved COPD exacerbations prolon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::640ee11d9cecd76607e17c5e6c796a5b
http://hdl.handle.net/10044/1/78157

Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial.

Autor: Chowdary P; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Cancer Institute, University College London, London WC1E 6DD, UK., Agarwal B; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Peralta MR; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Cancer Institute, University College London, London WC1E 6DD, UK., Bhagani S; Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Lee S; Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Goldring J; Respiratory Medicine, Royal Free London NHS Foundation Trust, London NW1 2BU, UK., Lipman M; Respiratory Medicine, Royal Free London NHS Foundation Trust, London NW1 2BU, UK.; UCL Respiratory, University College London, London WC1E 6JF, UK., Waqif E; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Phillips M; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Cancer Institute, University College London, London WC1E 6DD, UK., Philippou H; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK., Foley JH; Freeline Therapeutics, London SG1 2BP, UK., Mutch NJ; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Ariëns RAS; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK., Stringer KA; Department of Clinical Pharmacy, College of Pharmacy University of Michigan, Ann Arbor, MI 48109, USA.; Division of Pulmonary and Critical Care Medicine, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Ricciardi F; Department of Statistical Science, University College London, London WC1E 6BT, UK., Watissée M; WStats Limited, Winchester SO23 8GH, UK., Hughes D; Cancer Institute, University College London, London WC1E 6DD, UK., Nathwani A; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Cancer Institute, University College London, London WC1E 6DD, UK., Riddell A; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Haemophilia & Thrombosis Laboratory (Health Services Laboratories), Royal Free Hospital, London WC1H 9AX, UK., Patch D; Department of Hepatology, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Buckley J; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., De Neef M; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Dimber R; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Diaz-Garcia C; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Patel H; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Nandani A; Clinical Trials Pharmacy, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Dissanayake U; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Chadwick N; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Alkhatip AAAMM; Department of Anaesthesia, Birmingham Children's Hospital, Birmingham B4 6NH, UK.; Department of Anaesthesia, Faculty of Medicine, Beni-Suef University Hospital, Beni-Suef University, Beni-Suef 2721562, Egypt., Watkinson P; NIHR Biomedical Research Centre Oxford, Oxford University Hospitals NHS Trust, University of Oxford, Oxford OX3 9DU, UK., Raith E; Bloomsbury Institute for Intensive Care Medicine, Department of Experimental and Translational Medicine, University College London, London WC1E 6JF, UK.; Discipline of Acute Care Medicine, School of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia., Singh S; Department of Respiratory and Critical Care Medicine, Chelsea & Westminster Hospital, London SW10 9NH, UK.; Department of Adult Intensive Care, Royal Brompton Hospital, London SW3 6NP, UK.; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Wolff T; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Jha R; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Brill SE; UCL Respiratory, University College London, London WC1E 6JF, UK., Bakhai A; Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Department of Cardiology, Royal Free London NHS Foundation Trust, London NW3 2PS, UK., Evans A; University College London (UCL)/University College London Hospitals NHS Trust (UCLH) Joint Research Office, London WC1E 6BT, UK., Gilani F; University College London (UCL)/University College London Hospitals NHS Trust (UCLH) Joint Research Office, London WC1E 6BT, UK., Gomez K; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.; Cancer Institute, University College London, London WC1E 6DD, UK.

Publikováno v: Journal of clinical medicine [J Clin Med] 2023 Sep 08; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 08.

The high mental health burden of "Long COVID" and its association with on-going physical and respiratory symptoms in all adults discharged from hospital.

Autor: Naidu SB; Royal Free London NHS Foundation Trust, London, UK., Shah AJ; Royal Free London NHS Foundation Trust, London, UK., Saigal A; Royal Free London NHS Foundation Trust, London, UK., Smith C; Institute for Global Health, University College London, London, UK., Brill SE; Royal Free London NHS Foundation Trust, London, UK., Goldring J; Royal Free London NHS Foundation Trust, London, UK., Hurst JR; Royal Free London NHS Foundation Trust, London, UK.; UCL Respiratory, University College London, London, UK., Jarvis H; Royal Free London NHS Foundation Trust, London, UK., Lipman M; Royal Free London NHS Foundation Trust, London, UK.; UCL Respiratory, University College London, London, UK., Mandal S; Royal Free London NHS Foundation Trust, London, UK swapnamandal@nhs.net.

Publikováno v: The European respiratory journal [Eur Respir J] 2021 Jun 24; Vol. 57 (6). Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).

Glycinergic Transmission in the Presence and Absence of Functional GlyT2: Lessons From the Auditory Brainstem.

Autor: Brill SE; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany., Maraslioglu A; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany., Kurz C; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany., Kramer F; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany., Fuhr MF; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany., Singh A; Electrical & Computer Engineering, University of Delaware, Newark, DE, United States., Friauf E; Animal Physiology Group, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany.

Publikováno v: Frontiers in synaptic neuroscience [Front Synaptic Neurosci] 2021 Feb 09; Vol. 12, pp. 560008. Date of Electronic Publication: 2021 Feb 09 (Print Publication: 2020).

Atypical presentations of COVID-19 in care home residents presenting to secondary care: A UK single centre study.

Autor: Rawle MJ; Department of Geriatric Medicine Barnet Hospital Royal Free London NHS Foundation Trust London UK.; MRC Unit for Lifelong Health and Ageing at UCL London UK., Bertfield DL; Department of Geriatric Medicine Barnet Hospital Royal Free London NHS Foundation Trust London UK., Brill SE; Department of Respiratory Medicine Barnet Hospital Royal Free London NHS Foundation Trust London UK.

Publikováno v: Aging medicine (Milton (N.S.W)) [Aging Med (Milton)] 2020 Sep 17; Vol. 3 (4), pp. 237-244. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).