Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brijesh Darji"'
Autor:
Sameer Agarwal, Santosh Sasane, Jeevan Kumar, Brijesh Darji, Hitesh Bhayani, Shubhangi Soman, Neelima Kulkarni, Mukul Jain
Publikováno v:
Medicine in Drug Discovery, Vol 1, Iss , Pp - (2019)
TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and act
Externí odkaz:
https://doaj.org/article/e49487f762a94e9c8a394fa0a714e79b
Autor:
Jigar, Desai, Bhaumin, Patel, Brijesh, Darji, Archana, Gite, Nandini, Panchal, Gokul, Bhosale, Sandeep, Shedage, Sandip, Patel, Pravin, Kadam, Gautam, Patel, Brijesh, Kumar Srivastava, Amit, Joharapurkar, Samadhan, Kshirsagar, Poonam, Giri, Hitesh, Bhayani, Ankit, Patel, Krishnarup, Ghoshdastidar, Debdutta, Bandyopadhyay, Sanjay, Kumar, Mukul, Jain, Rajiv, Sharma
Publikováno v:
Bioorganicmedicinal chemistry letters. 53
Amino acid restriction by inhibition of neutral amino acid transporter, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c663a0c24146a8954bef975489f98ee
https://pubmed.ncbi.nlm.nih.gov/34718128
https://pubmed.ncbi.nlm.nih.gov/34718128
Autor:
Amit Joharapurkar, Debdutta Bandyopadhyay, Jigar Desai, Ankit Patel, Gautam Patel, Brijesh Kumar Srivastava, Poonam Giri, Gokul Bhosale, Sandeep A. Shedage, Krishnarup Ghoshdastidar, Sandip Patel, Archana Gite, Sanjay Kumar, Hitesh Bhayani, Samadhan Kshirsagar, Brijesh Darji, Pravin Kadam, Nandini Panchal, Rajiv P. Sharma, Mukul R. Jain, Bhaumin Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 53:128421
Amino acid restriction by inhibition of neutral amino acid transporter, B0AT1 (SLC6A19) activity has been recently shown to improve glyceamic control by upregulating glucagon like peptide (GLP1) and fibroblast growth factor (FGF21) in mice. Hence, ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4345692009c8b402c583648e63b7c243
https://doi.org/10.1016/j.bmcl.2021.128421
https://doi.org/10.1016/j.bmcl.2021.128421
Autor:
Suresh Giri, Ranjit C. Desai, Prashant K. Deshmukh, Mukul R. Jain, Sameer Agarwal, Amit B. Patil, Umesh Aware, Priyanka Priyadarsiny, Poonam Giri, Brijesh Darji, Kalapatapu V.V.M. Sairam, Harilal Patel, Santosh Sasane
Publikováno v:
ACS Medicinal Chemistry Letters. 7:51-55
TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaa34afb099c04011bf2aff9981f2ea
https://doi.org/10.1021/acsmedchemlett.5b00323
https://doi.org/10.1021/acsmedchemlett.5b00323
Autor:
Santosh Sasane, Sameer Agarwal, Jeevan Kumar, Neelima D. Kulkarni, Brijesh Darji, Shubhangi S. Soman, Hitesh Bhayani, Mukul R. Jain
Publikováno v:
Medicine in Drug Discovery, Vol 1, Iss, Pp-(2019)
TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89fea5ad6652d45f428e8b4235447d5
https://doi.org/10.1016/j.medidd.2019.100002
https://doi.org/10.1016/j.medidd.2019.100002
Autor:
Brijesh Darji
Publikováno v:
IOSR Journal of Engineering. :573-576
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2331c7f4914b9b2a7466aa20bde7ec81
https://doi.org/10.9790/3021-0204573576
https://doi.org/10.9790/3021-0204573576
Autor:
Dipam Patel, Pradip Jadav, Yernaidu Siriki, Rajesh Bahekar, Amit Joharapurkar, Debdutta Bandyopadhyay, Mubeen Shaikh, Samadhan Kshirsagar, Harilal Patel, Brijesh Darji, Kalapatapu V.V.M. Sairam, Shailesh R. Shah, Mukul R. Jain, Pankaj R. Patel
Publikováno v:
ChemMedChem. 6:1011-1016
The worldwide incidence of metabolic syndromes such as obesity and diabetes are increasing at an alarming rate. Patients that suffer from obesity-induced type 2 diabetes (informally known as diabesity) are at increased risk of cardiovascular disease;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2a2abb335a80a8e4217f55ae33c224
https://doi.org/10.1002/cmdc.201100077
https://doi.org/10.1002/cmdc.201100077