Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Brij B. Singh"'
Autor:
Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang, Prabhakar Pitta Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra Lee Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Brij B. Singh, Philip T. Valente, Yidong Chen, Zhao Lai, Manjeet Rao, Edward R. Kost, Tyler Curiel, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise m
Externí odkaz:
https://doaj.org/article/9ac36726d5db494b89c1884b726a9b5c
Autor:
Viviane Nascimento Da Conceicao, Yuyang Sun, Xiufang Chai, Julian L. Ambrus, Bibhuti B. Mishra, Brij B. Singh
Publikováno v:
Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100210- (2023)
Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren’s syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces Ca2+ signaling that restores
Externí odkaz:
https://doaj.org/article/9e92e7a3049f4ff291675e1afd8ebaaa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Clinical studies and structural analyses of salivary stones strongly suggest a linkage between higher saliva calcium (Ca2+) and salivary stone formation, sialolithiasis; however, the process and the mechanism leading to Ca2+ overload during
Externí odkaz:
https://doaj.org/article/8474bde770364b0d8e077eaf9de622b1
Autor:
Olivia N. Tran, Hanzhou Wang, Shengxian Li, Andrey Malakhov, Yuyang Sun, Parveez A. Abdul Azees, Aaron O. Gonzalez, Brian Cao, Milos Marinkovic, Brij B. Singh, David D. Dean, Chih-Ko Yeh, Xiao-Dong Chen
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Background Current treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the disease. SG-derived stem cells have the potential to treat SG hypofunction, but their isolation i
Externí odkaz:
https://doaj.org/article/e60471870a1348438dd9f6f5f6281a66
Autor:
Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown. The aim of this study was to understan
Externí odkaz:
https://doaj.org/article/8bdeafee9ff34986b09a865f4a911568
Autor:
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112155- (2023)
Summary: The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition rem
Externí odkaz:
https://doaj.org/article/324fd2ad3fb9463fa4701a04cb364947
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 4, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/f5b59ea243fd445381d05b287a34f487
Autor:
Naseem Ahamad, Yuyang Sun, Viviane Nascimento Da Conceicao, Caroline R. D. Xavier Paul Ezhilan, Mohan Natarajan, Brij B. Singh
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Stem cells have indefinite self-renewable capability; however, factors that modulate their pluripotency/function are not fully identified. Here we show that store-dependent Ca2+ entry is essential for modulating the function of bone marrow-d
Externí odkaz:
https://doaj.org/article/fac4efa4bb444194b3de6e814f91a950
Autor:
Yuyang Sun, Emily K. Zboril, Jorge J. De La Chapa, Xiufang Chai, Viviane Nascimento Da Conceicao, Matthew C. Valdez, Stanton F. McHardy, Cara B. Gonzales, Brij B. Singh
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Oral cancer patients have a poor prognosis, with approximately 66% of patients surviving 5-years after diagnosis. Treatments for oral cancer are limited and have many adverse side effects; thus, further studies are needed to develop drugs that are mo
Externí odkaz:
https://doaj.org/article/c7f11cbee0e24145a6b0354762e7fe89
Autor:
Arun Chauhan, Atul Sharma, Jitendra K. Tripathi, Yuyang Sun, Pramod Sukumran, Brij B. Singh, Bibhuti B. Mishra, Jyotika Sharma
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Despite their protective antimicrobial function, neutrophil extracellular traps (NETs) have been implicated in propagation of inflammatory responses in several disease conditions including sepsis. Highly diffusible exogenous ROS produced und
Externí odkaz:
https://doaj.org/article/0e1117b6c90149c6a59d5744a74a5e5e