Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Brij B. Saxena"'
Autor:
Young A Han, Premila Rathnam, Brij B. Saxena, Mukul Singh, Jeffrey Laurence, Sidney Lerner, Dingyi Fu
Publikováno v:
AIDS. 23:917-922
Objective: An effective vaginal microbicide against sexual HIV transmission remains elusive, with requirements for adherence to appropriate application of effective, nontoxic products being a major deterrent. We explored methods to enable sustained r
Autor:
Eileen Kisilis, Ozgur Oktem, Brij B. Saxena, Lei Zhu, Premila Rathnam, Meirong Hao, Arkadiy Bomshteyn, Meena Katdare
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6349-6358
Betulonic acid, derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures. However, due to the lack of solubility of betulonic acid in aqueous medium, its potent anti-cancer act
Autor:
Brij B. Saxena, Jerry I. Jacobson, Benjamin J. Scherlag, John Lamberth, Anjali Saxena, William S. Yamanashi
Publikováno v:
Medical Hypotheses. 60:821-839
We seek to answer the conundrum: What is the fundamental mechanism by which very weak, low frequency Electromagnetic fields influence biosystems? In considering the hydrophobicity of intramembranous protein (IMP) H-bonds which cross the phospholipid
Autor:
Mukul Singh, Premila Rathnam, Brij B. Saxena, Y Bukharovich, A Saxena, A Clavio, T Reimers, Scott Perkins
Publikováno v:
Reproduction in Domestic Animals. 37:9-17
Adult female dogs were immunized with 0.5 mg bovine luteinizing hormone receptor (LH-R) encapsulated in a silastic subdermal implant and subsequently with four intramuscular booster injections of 0.1 mg LH-R each. Circulating LH-R antibody was detect
Publikováno v:
Advances in Contraception. 13:1-11
Safety contraceptive efficacy and acceptability of norethindrone encapsulated in biodegradable poly-dl-lactide-co-glycolide injectable microspheres (NET-90) was evaluated for 12 months in 100 women. 51 volunteers received 65 mg and 49 received 100 mg
Publikováno v:
Fertility and Sterility. 66:954-961
To evaluate the contraceptive efficacy, pharmacokinetics, and safety of two formulations of Annuelle (Endocon, Inc., South Walpole, MA) biodegradable norethindrone (NET) SC pellet implants.Prospective observational study.Two clinical sites in the Uni
Development of vaginal rings for sustained release of nonhormonal contraceptives and anti-HIV agents
Publikováno v:
Contraception. 76(2)
Objectives Construction of vaginal rings to deliver nonhormonal contraceptives and 3���-Azido-3���-deoxythymidine (AZT) as an anti-HIV agent and determination of their daily release and efficacy in vitro. Materials and Methods Intravagina
Publikováno v:
Journal of reproductive immunology. 63(2)
Human lutropin (hLH) and human chorionic gonadotropin (hCG) are structurally and functionally similar and play important roles in reproduction via a common gonadal receptor (LH-R). However, hormone specific hCG-beta subunit contains 24 additional ami
Autor:
Premila Rathnam, Brij B. Saxena, Abbie Clavio, Mukul Singh, Thomas J. Reimers, Anjali Saxena, Scott Perkins, E. Yaroslaw Bukharovich
Publikováno v:
American journal of veterinary research. 64(3)
Objective—To determine the effect of immunization with bovine luteinizing hormone receptor (LH-R) on ovarian function of cats. Animals—9 adult female domestic cats. Procedure—7 cats were immunized with 0.5 mg of LH-R encapsulated in a silastic
A mutation in the first transmembrane domain of the lutropin receptor causes male precocious puberty
Autor:
Jörg Gromoll, Brij B. Saxena, Carl-Joachim Partsch, Verena Nordhoff, Manuela Simoni, Wolfgang G. Sippell, Eberhard Nieschlag
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(2)
We describe a patient with onset of puberty at the age of 5 yr. characterized by accelerated growth, enlargement of genitalia, pubarche, and serum hormone levels compatible with noncentral precocious puberty. Exon 11 of the LH receptor gene was ampli