Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Brigitte Wotzel"'
Autor:
Kamilla Bakowska-Zywicka, Matthias Erlacher, Norbert Polacek, Melanie Amort, Ronald Micura, Brigitte Wotzel
Publikováno v:
Nucleic Acids Research
Peptide bond formation and peptidyl-tRNA hydrolysis are the two elementary chemical reactions of protein synthesis catalyzed by the ribosomal peptidyl transferase ribozyme. Due to the combined effort of structural and biochemical studies, details of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303c5be61de4e9232d248c026ce4ba47
https://doi.org/10.1093/nar/gkm539
https://doi.org/10.1093/nar/gkm539
Autor:
Ronald Micura, Brigitte Wotzel, Kathrin Lang, Norbert Polacek, Alexander Hüttenhofer, Nisha Shankaran, Alexander S. Mankin, Matthias D. Erlacher
Publikováno v:
Nucleic Acids Research
The main enzymatic reaction of the large ribosomal subunit is peptide bond formation. Ribosome crystallography showed that A2451 of 23S rRNA makes the closest approach to the attacking amino group of aminoacyl-tRNA. Mutations of A2451 had relatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7b1d7725855329049a837d2d64b1aa
https://doi.org/10.1093/nar/gki308
https://doi.org/10.1093/nar/gki308
Autor:
Renate Rieder, Norbert Polacek, Kathrin Lang, Ronald Micura, Brigitte Wotzel, Matthias D. Erlacher
Publikováno v:
Journal of the American Chemical Society. 128(13)
The ribosomal peptidyl transferase center is a ribozyme catalyzing peptide bond synthesis in all organisms. We applied a novel modified nucleoside interference approach to identify functional groups at 9 universally conserved active site residues. Ow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98a5601be33555ce33e3b3d8089b979
https://pubmed.ncbi.nlm.nih.gov/16569023
https://pubmed.ncbi.nlm.nih.gov/16569023