Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study.

Autor: Brigitte Vulliez-Le Normand, Frederick A Saul, Sylviane Hoos, Bart W Faber, Graham A Bentley

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183198 (2017)

Malaria, a disease endemic in many tropical and subtropical regions, is caused by infection of the erythrocyte by the apicomplexan parasite Plasmodium. Host-cell invasion is a complex process but two Plasmodium proteins, Apical Membrane Antigen 1 (AM

Externí odkaz: https://doaj.org/article/f3d9d672727a4fb09f1c5715d7ed9876

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody.

Autor: Brigitte Vulliez-Le Normand, Bart W Faber, Frederick A Saul, Marjolein van der Eijk, Alan W Thomas, Balbir Singh, Clemens H M Kocken, Graham A Bentley

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123567 (2015)

The malaria parasite Plasmodium knowlesi, previously associated only with infection of macaques, is now known to infect humans as well and has become a significant public health problem in Southeast Asia. This species should therefore be targeted in

Externí odkaz: https://doaj.org/article/990ee2b45f2b45609f5d3921acc936b2

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites.

Autor: Mauld Lamarque, Sébastien Besteiro, Julien Papoin, Magali Roques, Brigitte Vulliez-Le Normand, Juliette Morlon-Guyot, Jean-François Dubremetz, Sylvain Fauquenoy, Stanislas Tomavo, Bart W Faber, Clemens H Kocken, Alan W Thomas, Martin J Boulanger, Graham A Bentley, Maryse Lebrun

Publikováno v: PLoS Pathogens, Vol 7, Iss 2, p e1001276 (2011)

Obligate intracellular Apicomplexa parasites share a unique invasion mechanism involving a tight interaction between the host cell and the parasite surfaces called the moving junction (MJ). The MJ, which is the anchoring structure for the invasion pr

Externí odkaz: https://doaj.org/article/96c12d395cf04f35a4327152c159f9d6

Comparative structural studies of two natural isoforms of ammodytoxin, phospholipases A2 from Vipera ammodytes ammodytes which differ in neurotoxicity and anticoagulant activity☆

Autor: Petra Prijatelj-Žnidaršič, Brigitte Vulliez-Le Normand, Frederick Saul, Joze Pungercar, Igor Križaj, Grazyna Faure, Bertrand Raynal, Benoit Villette

Publikováno v: Journal of Structural Biology. 169:360-369

Ammodytoxin A (AtxA) and its natural isoform AtxC from the venom of Vipera ammodytes ammodytes belong to group IIA-secreted phospholipases A2 which catalyze the hydrolysis of glycerophospholipids and exhibit strong neurotoxic and anticoagulant effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e346e215c26de9bfec95ecdba7ddf1b
https://doi.org/10.1016/j.jsb.2009.10.010

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody

Autor: Clemens H. M. Kocken, Brigitte Vulliez-Le Normand, Frederick Saul, Bart W. Faber, Balbir Singh, Graham A. Bentley, Marjolein van der Eijk, Alan W. Thomas

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (4), pp.e0123567. ⟨10.1371/journal.pone.0123567⟩
PLoS ONE, 2015, 10 (4), pp.e0123567. ⟨10.1371/journal.pone.0123567⟩
'PloS One ', vol: 10, pages: e0123567-1-e0123567-16 (2015)
PLoS ONE, Vol 10, Iss 4, p e0123567 (2015)

International audience; The malaria parasite Plasmodium knowlesi, previously associated only with infection of macaques, is now known to infect humans as well and has become a significant public health problem in Southeast Asia. This species should t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f7e58c05e8a8bcfc4183c13e77d2b7
https://pubmed.ncbi.nlm.nih.gov/25886591