Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Brigitte Sturm"'
Autor:
Rajeswari R. Moganty, Hans Goldenberg, Barbara Scheiber-Mojdehkar, Hannes Steinkellner, Himanshu Narayan Singh, Brigitte Sturm, Martina U. Muckenthaler
Publikováno v:
Gene. 621:5-11
Friedreich's ataxia (FRDA) is a neurodegenerative disease caused by reduced expression of the protein frataxin. Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis. In this study, we used erythroid progenitor stem
Autor:
Monika Praschberger, Kathrin Haider, Hans Goldenberg, Brigitte Sturm, Carolin Cornelius, Markus Schitegg, Barbara Scheiber-Mojdehkar
Publikováno v:
BioMetals. 28:35-50
Intravenous iron preparations, like iron sucrose (IS) and ferric carboxymaltose (FCM) differ in their physicochemical stability. Thus differences in storage and utilization can be expected and were investigated in a non-clinical study in liver parenc
Autor:
Wolfgang Nachbauer, Barbara Scheiber-Mojdehkar, Sylvia Boesch, Marek Kubicki, Michael Schocke, Karl Egger, Christian Clemm von Hohenberg, Martha E. Shenton, Brigitte Sturm, Demian Wassermann, Christian Kremser, Charles R.G. Guttmann, Marlene C. Wigand
Publikováno v:
Journal of Neuroimaging. 24:504-508
BACKGROUND AND PURPOSE Erythropoietin (EPO) has received growing attention because of its neuroregenerative properties. Preclinical and clinical evidence supports its therapeutic potential in brain conditions like stroke, multiple sclerosis, and schi
Autor:
Markus Reindl, Wolfgang Nachbauer, Andreas Eigentler, Barbara Scheiber-Mojdehkar, Brigitte Sturm, Werner Poewe, Sylvia Boesch, Julia Wanschitz, Hannes Steinkellner, Kurt Hufler
Publikováno v:
Movement Disorders. 26:1935-1938
Background: Friedreich ataxia is an autosomal recessive disorder caused by mutations in the frataxin gene, leading to reduced levels of the mitochondrial protein frataxin. Assays to quantitatively measure frataxin in peripheral blood have been establ
Autor:
Sascha Hering, Brigitte Sturm, Guenter Weiss, Alexander Strasak, Markus Seifert, Hannes Steinkellner, Barbara Scheiber-Mojdehkar, Wolfgang Nachbauer, Sylvia Boesch, Werner Poewe, Markus Reindl
Publikováno v:
The Cerebellum. 10:763-769
Friedreich ataxia (FRDA) is an autosomal recessive inherited neurodegenerative disorder leading to reduced expression of the mitochondrial protein frataxin. Previous studies showed frataxin upregulation in FRDA following treatment with recombinant hu
Autor:
Sylvia Boesch, Barbara Scheiber-Mojdehkar, Werner Poewe, Wolfgang Nachbauer, Rainer Schneider, Sascha Hering, Brigitte Sturm, Hannes Steinkellner
Publikováno v:
The Open Drug Discovery Journal. 2:18-24
In vitro and in vivo studies have provided evidence for neuroprotective properties of Erythropoietin in neurodegenerative disorders. Although the magnitude of effect is still controversial, very recent findings point to neuronal protection in the cen
Autor:
Hannes Steinkellner, Hans Goldenberg, Brigitte Sturm, Barbara Scheiber-Mojdehkar, Mohammad Mehdi Heidari, Melissa Helminger
Publikováno v:
European Journal of Clinical Investigation. 40:561-565
Eur J Clin Invest 2010; 40 (6): 561–565 Abstract Background Friedreich’s ataxia (FRDA) is a neurodegenerative disorder caused by decreased expression of the mitochondrial protein frataxin. Recently we showed in a clinical pilot study in Friedreic
Autor:
Hannes Steinkellner, Brigitte Sturm, Hans Goldenberg, Werner Poewe, Barbara Scheiber-Mojdehkar, Sylvia Boesch, Sascha Hering
Publikováno v:
Movement Disorders. 23:1940-1944
In a "proof-of-concept" study, we demonstrated that recombinant human erythropoietin (rhuEPO) increases frataxin levels in Friedreich's ataxia (FRDA) patients. We now report a 6-month open-label clinical pilot study of safety and efficacy of rhuEPO t
Publikováno v:
Nephrology Dialysis Transplantation. 22:2824-2830
Background. Intravenous iron (IVI) therapy is required in patients with end-stage renal disease (ESRD) under chronic haemodialysis (HD). In this in vitro study we investigated the availability and stability of iron hydroxyethyl starch (iron-Hes) comp
Autor:
Geneieve Tai, Monika Praschberger, Andrew Churchyard, Martin B. Delatycki, Barbara Scheiber-Mojdehkar, Katherine J Lee, Sarah E.M. Stephenson, Louise A. Corben, Monique M. Ryan, Adam P. Vogel, Eppie M. Yiu, Gary Rance, Creina S. Stockley, Chung-Yung J. Lee, Marguerite V. Evans-Galea, Brigitte Sturm, Joseph P. Sarsero, Kevin D. Croft, Roger E. Peverill, Trevor A. Mori, Paul J. Lockhart
Publikováno v:
ResearcherID
Friedreich ataxia (FRDA) is due to a triplet repeat expansion in FXN, resulting in deficiency of the mitochondrial protein frataxin. Resveratrol is a naturally occurring polyphenol, identified to increase frataxin expression in cellular and mouse mod