Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Brigitte N Gomperts"'
Autor:
Derek W Nickerson, Angela P Presson, Stephen S Weigt, Aric L Gregson, John A Belperio, Brigitte N Gomperts
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5925 (2009)
Circulating epithelial progenitor cells are important for repair of the airway epithelium in a mouse model of tracheal transplantation. We therefore hypothesized that circulating epithelial progenitor cells would also be present in normal human subje
Externí odkaz:
https://doaj.org/article/44e89d3f879c4815b49214258302ff53
Autor:
Rachana R. Chandran, Taylor S. Adams, Inamul Kabir, Eunate Gallardo-Vara, Naftali Kaminski, Brigitte N. Gomperts, Daniel M. Greif
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Alveolarization ensures sufficient lung surface area for gas exchange, and during bulk alveolarization in mice (postnatal day [P] 4.5–14.5), alpha-smooth muscle actin (SMA)+ myofibroblasts accumulate, secrete elastin, and lay down alveolar septum.
Externí odkaz:
https://doaj.org/article/b942c13124314f1096ff19c7c8478d5e
Autor:
Qi Cui, Arjit Vijey Jeyachandran, Gustavo Garcia jr., Chao Qin, Yu Zhou, Mingzi Zhang, Cheng Wang, Guihua Sun, Wei Liu, Tao Zhou, Lizhao Feng, Chance Palmer, Zhuo Li, Adam Aziz, Brigitte N. Gomperts, Pinghui Feng, Vaithilingaraja Arumugaswami, Yanhong Shi
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causal agent for coronavirus disease 2019 (COVID‐19). Although vaccines have helped to prevent uncontrolled viral spreading, our understanding of the fundamental biolo
Externí odkaz:
https://doaj.org/article/81c88b3fb37e42ad884dc34e3347c863
Autor:
Chandani Sen, Caroline R. Koloff, Souvik Kundu, Dan C. Wilkinson, Juliette M. Yang, David W. Shia, Luisa K. Meneses, Tammy M. Rickabaugh, Brigitte N. Gomperts
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Small-cell-lung-cancer (SCLC) has the worst prognosis of all lung cancers because of a high incidence of relapse after therapy. While lung cancer is the second most common malignancy in the US, only about 10% of cases of lung cancer are
Externí odkaz:
https://doaj.org/article/2af5fac1373f4220879f3a52faeb2175
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Cody Aros, Carla Pantoja, and Brigitte Gomperts review the key role of Wnt signaling in all aspects of lung development, repair, and disease progression. They provide an overview of recent research findings and highlight where research is needed to f
Externí odkaz:
https://doaj.org/article/3a337241a9a349a897f13e215c68cf51
Autor:
Peter J. Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W. Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B. Shackelford, Robert Damoiseaux, Samuel W. French, Kathrin Plath, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Heather R. Christofk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate vira
Externí odkaz:
https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc6
Autor:
Paul G. Ayoub, Arunima Purkayastha, Jason Quintos, Curtis Tam, Lindsay Lathrop, Kevin Tam, Marlene Ruiz, Roger P. Hollis, Brigitte N. Gomperts, Donald B. Kohn
Publikováno v:
Frontiers in Virology, Vol 1 (2021)
The spike (S) glycoprotein of SARS-Cov-2 facilitates viral entry into target cells via the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Third generation HIV-1 lentiviral vectors can be pseudotyped to replace the native CD4 tropic env
Externí odkaz:
https://doaj.org/article/efa1938c3f3c4807a4e0cd637ebbc8fb
Autor:
David W. Shia, WooSuk Choi, Preethi Vijayaraj, Valarie Vuong, Jenna M. Sandlin, Michelle M. Lu, Adam Aziz, Caliope Marin, Cody J. Aros, Chandani Sen, Abdo Durra, Andrew J. Lund, Arunima Purkayastha, Tammy M. Rickabaugh, Thomas G. Graeber, Brigitte N. Gomperts
Publikováno v:
Oncogene, vol 42, iss 6
Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination chemotherapy. The key drivers of such rapid mortality include early metastatic dissemination in the na
Autor:
Cody J. Aros, Manash K. Paul, Carla J. Pantoja, Bharti Bisht, Luisa K. Meneses, Preethi Vijayaraj, Jenna M. Sandlin, Bryan France, Jonathan A. Tse, Michelle W. Chen, David W. Shia, Tammy M. Rickabaugh, Robert Damoiseaux, Brigitte N. Gomperts
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2055-2064.e5 (2020)
Summary: Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer p
Externí odkaz:
https://doaj.org/article/a599394ed7284d46981ea5a3afde29bc
Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule
Autor:
Preethi Vijayaraj, Aspram Minasyan, Abdo Durra, Saravanan Karumbayaram, Mehrsa Mehrabi, Cody J. Aros, Sarah D. Ahadome, David W. Shia, Katherine Chung, Jenna M. Sandlin, Kelly F. Darmawan, Kush V. Bhatt, Chase C. Manze, Manash K. Paul, Dan C. Wilkinson, Weihong Yan, Amander T. Clark, Tammy M. Rickabaugh, W. Dean Wallace, Thomas G. Graeber, Robert Damoiseaux, Brigitte N. Gomperts
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3488-3505.e9 (2019)
Summary: Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across
Externí odkaz:
https://doaj.org/article/d90d9879ef6b4ac98aad3a2310cc1d88