Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Brigitte Murat"'
Autor:
Justine S. Paradis, Xiang Feng, Brigitte Murat, Robert E. Jefferson, Badr Sokrat, Martyna Szpakowska, Mireille Hogue, Nick D. Bergkamp, Franziska M. Heydenreich, Martine J. Smit, Andy Chevigné, Michel Bouvier, Patrick Barth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.
Externí odkaz:
https://doaj.org/article/c0d899ae8609439f8ce39b8bdc95e8a4
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Identifying ligands which activate the specific effectors driving particular in vivo drug effects remains challenging. Here, the authors apply unsupervised clustering of pharmacodynamic parameters to classify GPCR ligands into different categories wi
Externí odkaz:
https://doaj.org/article/c0db3f1cf110426bbd5f35d40fd3681b
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1f09235de66f4fc295108bc582f6d396
Autor:
Stephen Jenkinson, Jonathan Gallion, Darren Cawkill, Brigitte Murat, Olivier Lichtarge, Yong Ren, Michel Bouvier, Karim Nagi, Emma T van der Westhuizen, Christian Le Gouill, Besma Benredjem, Viktoryia Lukasheva, Johanie Charbonneau, Paul Dallaire, Mark Gosink, Anne W. Schmidt, Christopher Somps, Dennis J. Pelletier, Graciela Piñeyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors should be specifically activat
Autor:
Yong Zhang, Madeleine Héroux, Bryan Cox, Brooke M Katzman, Brigitte Murat, Lawrence J. Wilson, Anthony R. Prosser, Ana A. Alcaraz, Dennis C. Liotta, Andrew J. Tebben, Gretchen M. Schroeder, James P. Snyder
[Image: see text] The rationale for the structural and mechanistic basis of a tetrahydroisoquinoline (THIQ) based series of CXCR4 antagonists is presented. Using the previously reported crystal structures which reveal two distinct binding sites of CX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed94921ea08225465c7be2c6bdcf6758
https://europepmc.org/articles/PMC6331156/
https://europepmc.org/articles/PMC6331156/
Autor:
Christopher Somps, Brigitte Murat, Jonathan Gallion, Yong Ren, Christian Le Gouill, Michel Bouvier, Dennis J. Pelletier, Stephen Jenkinson, Johanie Charbonneau, Paul Dallaire, Graciela Piñeyro, Olivier Lichtarge, Viktoryia Lukasheva, Karim Nagi, Anne W. Schmidt, Besma Benredjem, Darren Cawkill, Emma T van der Westhuizen, Mark Gosink
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Brigitte Murat, Dominic Devost, Véra Boulay, Maithé Corbani, Gilles Guillon, Miriam Andrés, Hans H. Zingg, Julie Mion
Publikováno v:
Molecular Endocrinology. 26:502-520
Vasopressin (AVP) and CRH synergistically regulate adrenocorticotropin and insulin release at the level of the pituitary and pancreas, respectively. Here, we first extended these AVP and CRH coregulation processes to the adrenal medulla. We demonstra
Autor:
Aurélie Fort, Frederique Ryckwaert, Brigitte Murat, Pascal Colson, Sylvain Richard, Gilles Guillon, Anne Virsolvy
Publikováno v:
Critical Care Medicine. 37:876-881
Terlipressin has been proposed as an alternative treatment to catecholamines to restore blood pressure in septic shock. Terlipressin is considered as a vasopressin prodrug capable of releasing small but sustained amounts of [Lysine] vasopressin (LVP)
Autor:
Ling Ling Cheng, Nga Ching Wo, Maurice Manning, Brigitte Murat, Miguel Trueba, Stoytcho Stoev, Ana Pena, Maria A. Ventura, Hazel H. Szeto, Gilles Guillon
Publikováno v:
Journal of Medicinal Chemistry. 50:835-847
The neurohypophyseal peptides arginine vasopressin (AVP) and oxytocin (OT) mediate a wide variety of peripheral and central physiological and behavioral effects by acting on four different G-protein coupled receptors, termed V1a (vascular), V1b (pitu
Autor:
Ling Ling Cheng, Brigitte Murat, Gilles Guillon, Nga Ching Wo, Miguel Trueba, Maurice Manning, Stoytcho Stoev, Maria A. Ventura, Ana Pena, Sylvain Derick, Hazel H. Szeto
Publikováno v:
Journal of Peptide Science. 12:190-198
Arginine vasopressin (AVP) mediates a wide variety of biological actions by acting on three distinct G-protein coupled receptors, termed V(1a) (vascular), V(1b) (pituitary) and V(2) (renal). It also binds to the oxytocin (OT) receptor. As part of a p