Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brigitte Maurer"'
Autor:
Julia Nehls, Ramona Businger, Markus Hoffmann, Constantin Brinkmann, Birgit Fehrenbacher, Martin Schaller, Brigitte Maurer, Caroline Schönfeld, Daniela Kramer, Stephan Hailfinger, Stefan Pöhlmann, Michael Schindler
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1841-1853.e6 (2019)
Summary: The Ebola virus glycoprotein (EBOV-GP) forms GP-containing microvesicles, so-called virosomes, which are secreted from GP-expressing cells. However, determinants of GP-virosome release and their functionality are poorly understood. We charac
Externí odkaz:
https://doaj.org/article/07bc6b29896e4290af031e69a39cda9f
Autor:
Guido Krebiehl, Sabine Ruckerbauer, Lena F Burbulla, Nicole Kieper, Brigitte Maurer, Jens Waak, Hartwig Wolburg, Zemfira Gizatullina, Frank N Gellerich, Dirk Woitalla, Olaf Riess, Philipp J Kahle, Tassula Proikas-Cezanne, Rejko Krüger
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9367 (2010)
Mitochondrial dysfunction and degradation takes a central role in current paradigms of neurodegeneration in Parkinson's disease (PD). Loss of DJ-1 function is a rare cause of familial PD. Although a critical role of DJ-1 in oxidative stress response
Externí odkaz:
https://doaj.org/article/2827ee8ffc42454eaa41fbf59e0c880b
Autor:
Brigitte Maurer
Publikováno v:
PADUA. 16:195-200
Zusammenfassung. Viele Auszubildende sind aufgrund ihrer bisherigen Lern- und Bildungsbiografie nur bedingt in der Lage sich selbstständig Lernziele zu setzen. Lernberatung stellt in diesem Zusammenhang ein fundiertes Instrument zur Förderung von S
Autor:
Christine Yu, Paul Gibbons, Daniel F. Ortwine, Eva Nittinger, Doug R. Davies, Jeremy Murray, Brigitte Maurer, Charles Eigenbrot, Vickie Tsui, Yong Tang, James R. Kiefer, Andreas Kuglstatter
Publikováno v:
Journal of computer-aided molecular design. 33(3)
Targeting the interaction with or displacement of the 'right' water molecule can significantly increase inhibitor potency in structure-guided drug design. Multiple computational approaches exist to predict which waters should be targeted for displace
Autor:
Racquel Corpuz, Ivan Bosanac, Mandy Kwong, Richard Vandlen, Kerstin Schmidt, Charles Eigenbrot, Brigitte Maurer, Steven Shia
Publikováno v:
Protein Science. 24:1440-1450
Interferons-alpha (IFN-α) are the expressed gene products comprising thirteen type I interferons with protein pairwise sequence similarities in the 77-96% range. Three other widely expressed human type I interferons, IFN-β, IFN-κ and IFN-ω have s
Autor:
Aaron C. Schmitt, Donna Dambach, Jen Macaluso, Kevin S. Currie, Xiaojing Wang, James Barbosa, Sarah G. Hymowitz, Kropf Jeffrey E, Steve Gallion, Peter Blomgren, Lichuan Liu, Scott A. Mitchell, Julie Di Paolo, Jin-Ming Xiong, Joseph W. Lubach, Pat Maciejewski, C. Gregory Sowell, Heleen Scheerens, Seung H. Lee, Karin Reif, Zhongdong Zhao, Wendy B. Young, Jianjun Xu, Harvey Wong, Brigitte Maurer, Daniel F. Ortwine, James J. Crawford, Meire Bremer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25(6):1333-1337
SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, b
Autor:
Manu Sharma, Anne-Kathrin Hauser, Rejko Krüger, Olaf Riess, Johannes Madlung, Rahel Lewin, Evangelia Vartholomaiou, Dheeraj Reddy Bobbili, L. Miguel Martins, Katja Schenke-Layland, Brigitte Maurer, Manuela Kübler, Richard Wüst, Thomas Gasser, Patrick May, Kevin M Schindler, Enrico Glaab, L. Schwarz, Alexander Zimprich, Christine Bus, Kathrin Brockmann, Didier Picard, Julia C. Fitzgerald, Alfred Nordheim, Claudia Schulte, Daniel A. Carvajal Berrio
Publikováno v:
Brain 140(9), 2444-2459 (2017). doi:10.1093/brain/awx202
Brain, Vol. 140, No 9 (2017) pp. 2444-2459
Brain
Brain, Vol. 140, No 9 (2017) pp. 2444-2459
Brain
The mitochondrial proteins TRAP1 and HTRA2 have previously been shown to be phosphorylated in the presence of the Parkinson's disease kinase PINK1 but the downstream signalling is unknown. HTRA2 and PINK1 loss of function causes parkinsonism in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe19a6fc272abd7b85a4345863221b2a
https://publica.fraunhofer.de/handle/publica/251322
https://publica.fraunhofer.de/handle/publica/251322
Autor:
Martin Schaller, Julia Nehls, Daniela Kramer, Michael Schindler, Birgit Fehrenbacher, Markus Hoffmann, Caroline Schönfeld, Brigitte Maurer, Ramona Businger, Stefan Pöhlmann, Stephan Hailfinger, Constantin Brinkmann
Publikováno v:
Cell Rep. 26, 1841-1853.e6 (2019)
Cell Reports, Vol 26, Iss 7, Pp 1841-1853.e6 (2019)
Cell Reports, Vol 26, Iss 7, Pp 1841-1853.e6 (2019)
Summary: The Ebola virus glycoprotein (EBOV-GP) forms GP-containing microvesicles, so-called virosomes, which are secreted from GP-expressing cells. However, determinants of GP-virosome release and their functionality are poorly understood. We charac
Autor:
Romain Legrand, Sergueï O. Fetissov, S. Nobis, Pierre Déchelotte, Sophie Claeyssens, L. Belmonte, Brigitte Maurer, Moïse Coëffier, Alexis Goichon, Najate Achamrah, Jean-Claude do Rego, Jean Luc Do Rego, Pierre Jésus, Jonathan Breton, Christine Bole-Feysot
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.21887. ⟨10.1038/srep21887⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep21887⟩
Scientific Reports, 2016, 6, pp.21887. ⟨10.1038/srep21887⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.21887. ⟨10.1038/srep21887⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep21887⟩
Scientific Reports, 2016, 6, pp.21887. ⟨10.1038/srep21887⟩
A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physi
Autor:
Kerry Zobel, Heidi J.A. Wallweber, Anna V. Fedorova, Domagoj Vucic, Allyn J. Schoeffler, Kurt Deshayes, J. Michael Elliott, Anthony M. Giannetti, Erin C. Dueber, Brigitte Maurer, Ping Wu, Andreas Lingel, Sarah G. Hymowitz, Eugene Varfolomeev, Wayne J. Fairbrother
Publikováno v:
Science. 334:376-380
Inhibitor of apoptosis (IAP) proteins are negative regulators of cell death. IAP family members contain RING domains that impart E3 ubiquitin ligase activity. Binding of endogenous or small-molecule antagonists to select baculovirus IAP repeat (BIR)