Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brigitte Lupo"'
Publikováno v:
Biochemistry. 40:8431-8437
A short C-terminal end is present at the end of the human androgen receptor (hAR) similar to that of other steroid receptors. It is located directly after helix 12 of the ligand binding domain and has never been described as being part of the hydroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fbd508c85370dce04428611fe2fec2
https://doi.org/10.1021/bi010146q
https://doi.org/10.1021/bi010146q
Autor:
Chantal Hellal-Levy, Brigitte Lupo, Marie-Edith Rafestin-Oblin, Gilles Auzou, Stéphan Jalaguier, Brigitte Couette, Jérôme Fagart
Publikováno v:
Molecular Endocrinology. 12:855-863
The effects of aldosterone are mediated by the mineralocorticoid receptor (MR), a ligand-dependent transcription factor. We investigated the structural determinants for ligand binding to the receptor using a series of human MR (hMR) deletion mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21466f179e5c34fb638f3ed152f0957f
https://doi.org/10.1210/mend.12.6.0119
https://doi.org/10.1210/mend.12.6.0119
Publikováno v:
Biochemical Journal. 324:57-63
To gain a better understanding of the mechanism of binding to the human mineralocorticoid receptor (hMR), we developed a new monoclonal antibody (mAb) raised against the hormone-binding domain (HBD). For this purpose, mice were immunized with a fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d9c09a24b0c96566bf40ca62469beb
https://doi.org/10.1042/bj3240057
https://doi.org/10.1042/bj3240057
Publikováno v:
Biochemistry. 37(35)
To assess the role of each of the four cysteine residues in the hormone binding domain (HBD) of the human mineralocorticoid receptor (hMR), we have separately substituted C808, C849, C910, and C942 into serine. These mutations were created in the G59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd661904d81d48e541150fe85fc947e
https://pubmed.ncbi.nlm.nih.gov/9724527
https://pubmed.ncbi.nlm.nih.gov/9724527
Autor:
Helene Leray, Brigitte Lupo, Dominique Bataille, Anne Virsolvy-Vergine, Sho Kuroki, Michel Dufour
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(14)
Antidiabetic sulfonylureas act through receptors coupled to ATP-dependent potassium channels. Using the binding of [3H]glibenclamide, a highly potent sulfonylurea, to rat brain membranes to follow the purification procedure, we extracted from ovine b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03efabe8b31ca08360f2a34cd254df1
https://pubmed.ncbi.nlm.nih.gov/1631165
https://pubmed.ncbi.nlm.nih.gov/1631165
Publikováno v:
Journal of Heterocyclic Chemistry. 21:545-550
La cyclisation intramoleculaire d'halogenomethyl-5 dipyrazolyl-1,3′(5′) methanes diversement substitues a conduit aux dihydro-4,9 dipyrazolo[1,5-a:1′,5′-d]pyrazines correspondantes selon une voie univoque, l'etude de la quaternarisation de ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2368f1be3b375088e01e5cbd06b4a78
https://doi.org/10.1002/jhet.5570210255
https://doi.org/10.1002/jhet.5570210255
Publikováno v:
Canadian Journal of Chemistry. 63:375-380
Synthese du derive trimethyl-2,7,12 du compose du titre a partir de chloromethyl-5 dimethyl-3,3' methylene-1,5' bis-pyrazole, d'hydrazine et de dioxo-2,4 valerate d'ethyle; l'etude RMN de cette nouvelle molecule dans divers solvants a pour la premier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2390d47dae60385910f2b626eeb489d0
https://doi.org/10.1139/v85-063
https://doi.org/10.1139/v85-063