Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person Syndrome.

Autor: Marta Rizzi, Rolf Knoth, Christiane S Hampe, Peter Lorenz, Marie-Lise Gougeon, Brigitte Lemercier, Nils Venhoff, Francesca Ferrera, Ulrich Salzer, Hans-Jürgen Thiesen, Hans-Hartmut Peter, Ulrich A Walker, Hermann Eibel

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10838 (2010)

Stiff person syndrome (SPS) is a rare, neurological disorder characterized by sudden cramps and spasms. High titers of enzyme-inhibiting IgG autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65) are a hallmark of SPS, implic

Externí odkaz: https://doaj.org/article/ad26bfdf619f451fadc46394dca96a25

Supplementary Figures 1-7 from The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

Autor: Claude Leclerc, Brigitte Lemercier, Annick Lim, Alexander Sainz-Perez

PDF file - 10MB, Figures S1-S5 present the strategy of analysis and purification of tumor-infiltrating Treg and Teff cells as well as their phenotypes and BV - BJ usage. The Figures S6-S7 present the qualitative spectratyping analysis of CDR3 length

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f302701850e7c4683c3ba413136d277
https://doi.org/10.1158/0008-5472.22393665

Public T cell receptors confer high-avidity CD4 responses to HIV controllers

Autor: Pierre de Truchis, Mathieu Claireaux, Alexandre Nouël, Lisa A. Chakrabarti, Moran Galperin, Samia Hendou, Daniela Benati, Pierre Lechat, Brigitte Lemercier, Annick Lim, Fernando Arenzana-Seisdedos, Olivier Lambotte, Jean-François Delfraissy, Kristy-Anne Campbell, Jamie Rossjohn, Stephanie Gras, Faroudy Boufassa, Madhura Mukhopadhyay

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2016, ⟨10.1172/JCI83792⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2016, ⟨10.1172/JCI83792⟩

International audience; The rare patients who are able to spontaneously control HIV replication in the absence of therapy show signs of a particularly efficient cellular immune response. To identify the molecular determinants that underlie this respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63f5ef9a7592cc37e40fe62b862aabb
https://europepmc.org/articles/PMC4887161/

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity

Autor: Frédéric Rieux-Laucat, Frank Yates, Marie-Lise Gougeon, Chantal Lagresle-Peyrou, Brigitte Lemercier, Jean-Pierre de Villartay, Olivier Danos, Michèle Malassis-Séris, Allen Liu, Marina Cavazzana-Calvo, Alexandrine Garrigue, Estelle Morillon, Alain Fischer, Daniel Stockholm, Christophe Hue, Philippe Hajdari

Publikováno v: Blood. 107:63-72

Severe combined immunodeficiency (SCID) caused by mutations in RAG1 or RAG2 genes is characterized by a complete block in T- and B-cell development. The only curative treatment is allogeneic hematopoietic stem cell transplantation, which gives a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c734aa8921b79670555dca82d6f59d35
https://doi.org/10.1182/blood-2005-05-2032

HIV Controller CD4+ T cells preferentially express a public TCR clonotype that confers high avidity responses against Gag

Autor: Daniela Benati, Moran, Galperin, Olivier, Lambotte, Annick, Lim, Brigitte, Lemercier, Madhura, Mukhopadhyay, Mathieu, Claireaux, Samia, Hendou, Faroudy, Boufassa, Jean-Francois, Delfraissy, Fernando, Arenzana-Seisdedos, Chakrabarti, Lisa A.

Publikováno v: Università degli studi di Modena e Reggio Emilia-IRIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::498634b3c38517e283fe4f0036037c4d
https://hdl.handle.net/11380/1154966