Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brigitte Kimmel"'
Autor:
Mohindar M. Karunakaran, Hariharan Subramanian, Yiming Jin, Fiyaz Mohammed, Brigitte Kimmel, Claudia Juraske, Lisa Starick, Anna Nöhren, Nora Länder, Carrie R. Willcox, Rohit Singh, Wolfgang W. Schamel, Viacheslav O. Nikolaev, Volker Kunzmann, Andrew J. Wiemer, Benjamin E. Willcox, Thomas Herrmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg
Externí odkaz:
https://doaj.org/article/f44499b1682d4024855a409410410b01
Autor:
Mohindar Murugesh Karunakaran, Hariharan Subramanian, Yiming Jin, Fiyaz Mohammed, Brigitte Kimmel, Claudia Juraske, Lisa Starick, Anna Nöhren, Nora Länder, Carrie R. Willcox, Rohit Singh, Wolfgang W. Schamel, Viacheslav O. Nikolaev, Volker Kunzmann, Andrew J. Wiemer, Benjamin E. Willcox, Thomas Herrmann
Butyrophilin (BTN)-3A and BTN2A1 molecules control TCR-mediated activation of human Vγ9Vδ2 T-cells triggered by phosphoantigens (PAg) from microbes and tumors, but the molecular rules governing antigen sensing are unknown. Here we establish three m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bda15829a12b35dce98f02acc1f458
https://doi.org/10.21203/rs.3.rs-2583246/v1
https://doi.org/10.21203/rs.3.rs-2583246/v1
Autor:
Lisa Starick, Mark Jeeves, Anna Nöhren, Carrie R. Willcox, Katie A Berwick, Paul A. Bates, Brigitte Kimmel, Alina Suzann Fichtner, Fiyaz Mohammed, Timothy J. Knowles, Vincent Pitard, Thomas Herrmann, Raphael A. G. Chaleil, Mahboob Salim, Daniel Paletta, Charlotte R Begley, Volker Kunzmann, Julie Déchanet-Merville, Mohindar Murugesh Karunakaran, Benjamin E. Willcox, Angela Noll, Lutz Walter
Publikováno v:
Immunity
Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory molecules,
Autor:
Martin Wilhelm, S Gundermann, Brigitte Kimmel, E Klinker, U Flierl, Hermann Einsele, Kunzmann
Publikováno v:
Journal of Immunotherapy. 37:321-330
Allogeneic innate lymphocytes such as Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy as they provide MHC-unrestricted antitumor activity without clinical evidence for inducing graft-versus-host disease (GvHD). However, current ce
Publikováno v:
Infection and Immunity. 68:915-920
Colonization of the gastric mucosa by Helicobacter pylori is the major cause of gastroduodenal pathologies in humans. Studying the outcome of the humoral immune response directed against this gastric pathogen may contribute substantially to vaccine d
Autor:
Thomas Herrmann, Jianqiang Li, Bladimiro Rincon-Orozco, Brigitte Kimmel, Ingrid Müller, Marco J Herold, Volker Kunzmann
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 182(12)
Human Vγ9Vδ2 T cells are characterized by a unique specificity for certain tumors (e.g., Daudi), cells presenting so-called phosphoantigens such as isopentenyl pyrophosphate (IPP), or cells treated with aminobisphosphonates. We now report conversio
Publikováno v:
Immunology. 126(2)
Tumour growth promotes the expansion of CD4(+) CD25(+) FoxP3(+) regulatory T cells (Tregs) which suppress various arms of immune responses and might therefore contribute to tumour immunosurveillance. In this study, we found an inverse correlation bet
Autor:
Martin Wilhelm, Volker Kunzmann, M Smetak, Josef Birkmann, H. Einsele, Brigitte Kimmel, Kerstin Schaefer-Eckart
Publikováno v:
Bone marrow transplantation. 41(7)
The ability to selectively deplete or enrich cells of specific phenotype by immunomagnetic selection to reduce the risk of GVHD holds significant promise for application in adoptive immunotherapy. Current clinical-scale approaches for T-cell depletio
Publikováno v:
Molecular microbiology. 27(5)
Despite the presence of highly conserved signalling modules, significant cross-communication between different two-component systems has only rarely been observed. Domain swapping and the characterization of liberated signalling modules enabled us to
Autor:
Martin Wilhelm, Volker Kunzmann, Josef Birkmann, Jürgen C. Becker, Karin Weigang-Koehler, Brigitte Kimmel, Ingo G.H. Schmidt-Wolf, M Smetak, H. Einsele, Mariele Goebeler
Publikováno v:
Journal of Clinical Oncology. 29:2569-2569
2569 Background: Emerging clinical evidence suggests that nitrogen-containing bisphosphonates such as zoledronic acid have direct and indirect anticancer effects including immunomodulatory effects ...