Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brigitte Herzog"'
Autor:
Elena Dolgodilina, Simone M. Camargo, Eva Roth, Brigitte Herzog, Virginia Nunes, Manuel Palacín, Francois Verrey
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Cerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it is nearly protein-free (~ 250-fold less) and contains about 2–20-fold less free amino ac
Externí odkaz:
https://doaj.org/article/f12de008640f4ffba9d23c7fe5642167
Autor:
Samyuktha Muralidharan Pillai, Brigitte Herzog, Petra Seebeck, Giovanni Pellegrini, Eva Roth, François Verrey
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The metabolism of dietary proteins generates waste products that are excreted by the kidney, in particular nitrogen-containing urea, uric acid, ammonia, creatinine, and other metabolites such as phosphates, sulfates, and protons. Kidney adaptation in
Externí odkaz:
https://doaj.org/article/8ee6177620c64b2eab01f5718f181c44
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184845 (2017)
Absorption of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B0AT1 (SLC6A19). Its intestinal expression depends on co-expression of the membrane-anchored peptidase ang
Externí odkaz:
https://doaj.org/article/38c8a8b451084e8a9d847142a47321c0
Autor:
Lalita Oparija-Rogenmozere, Nadège Poncet, Anuradha Rajendran, François Verrey, Brigitte Herzog
Publikováno v:
The Journal of Physiology
Key points LAT4 is a broadly expressed uniporter selective for essential branched chain amino acids, methionine and phenylalanine, which are involved in epithelial transport.Its global deletion leads to an early malnutrition‐like phenotype and deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18e0f207541fa606d3f0bb43e959334
http://europepmc.org/articles/PMC7693055
http://europepmc.org/articles/PMC7693055
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c4e4f4b3a5821356e714f7edbe3b68
https://doi.org/10.1096/fasebj.2019.33.1_supplement.575.12
https://doi.org/10.1096/fasebj.2019.33.1_supplement.575.12
Autor:
Lukas Bock, Simone M. R. Camargo, Luca Mariotta, Adriano Guetg, François Verrey, Ralph Fingerhut, Brigitte Herzog
Publikováno v:
J Physiol.
Key points Lat4 (Slc43a2) transports branched-chain amino acids, phenylalanine and methionine, and is expressed in kidney tubule and small intestine epithelial cells. Using a new knockout model as a negative control, it is shown that Lat4 is expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff4c5102a417dd8c9124658c67ab483
https://doi.org/10.1113/jphysiol.2014.283960
https://doi.org/10.1113/jphysiol.2014.283960
Publikováno v:
Am. J. Physiol. Regul. Integr. Comp. Physiol.
Diabetes mellitus is a disease characterized by elevated blood glucose levels and represents a worldwide health issue. Postprandial hyperglycemia is considered a major predictor of diabetic complications, and its reduction represents a specific treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6098867a2fc9ab474aaa7aced326e2
Autor:
Brigitte Herzog, Thomas A. Lutz, Christina N. Boyle, Josua Jordi, Simone M. R. Camargo, François Verrey
Publikováno v:
The Journal of Physiology. 591:5611-5621
Key points • Proteins are more satiating than fats or lipids. Proteins are built by the 20 proteogenic amino acids. • Here, we identified l-arginine, l-lysine and l-glutamic acid as the most potent anorectic amino acids in rats. • l-Arginine an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::965f790e632ae188ff4acafe89634601
https://doi.org/10.1113/jphysiol.2013.258947
https://doi.org/10.1113/jphysiol.2013.258947
Autor:
Brigitte Herzog, Simone M. R. Camargo, Dustin Singer, Tamara Ramadan, François Verrey, Manuel Palacín, Claudia Stoeger, Tony Lahoutte, Adriano Guetg, Luca Mariotta
Publikováno v:
The Journal of Physiology. 590:6413-6424
The uniporter TAT1 (Slc16a10) mediates the facilitated diffusion of aromatic amino acids (AAAs) across basolateral membranes of kidney, small intestine and liver epithelial cells, and across the plasma membrane of non-epithelial cells like skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339866030c795d1df8b06071d13bc4ad
https://doi.org/10.1113/jphysiol.2012.239574
https://doi.org/10.1113/jphysiol.2012.239574
Autor:
Martin Müllner, Kevin A. Sullivan, Michael E. Laurila, Richard D. Miller, Michael Leroy Phillips, Tanja Leitner, Mario Waser, David W. Hoard, Marvin M. Hansen, Chaoyu Xie, Marcus Kordian, Sandy S. K. Borders, Jeffrey A. Ward, Michael E. LeTourneau, Eric D. Moher, Cheryl A. Bye, Brigitte Herzog-Krimbacher
Publikováno v:
Organic Process Research & Development. 15:1266-1274
To fuel clinical development of the experimental CNS medicine LY2140023, we developed a scalable route for the multistep synthesis of a pivotal synthetic intermediate. The core of the conformationally restricted glutamic acid-based amino acid analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864de8e0e1bf7c7dd96cc65b0fc6c539
https://doi.org/10.1021/op100325h
https://doi.org/10.1021/op100325h