Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Brigitte Hampel"'
Autor:
Eva Tsaousidou, Lars Paeger, Bengt F. Belgardt, Martin Pal, Claudia M. Wunderlich, Hella Brönneke, Ursel Collienne, Brigitte Hampel, F. Thomas Wunderlich, Marc Schmidt-Supprian, Peter Kloppenburg, Jens C. Brüning
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1495-1506 (2014)
Activation of c-Jun N-terminal kinase 1 (JNK1)- and inhibitor of nuclear factor kappa-B kinase 2 (IKK2)-dependent signaling plays a crucial role in the development of obesity-associated insulin and leptin resistance not only in peripheral tissues but
Externí odkaz:
https://doaj.org/article/03308a07bb9f451ab9c56f319d751572
Autor:
Jan Mauer, Bhagirath Chaurasia, Leona Plum, Thomas Quast, Brigitte Hampel, Matthias Blüher, Waldemar Kolanus, C Ronald Kahn, Jens C Brüning
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000938 (2010)
A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory cytokines, which in turn leads to
Externí odkaz:
https://doaj.org/article/9b011073f41e434fb955e21b43d1c963
Autor:
Heiko Backes, Markus Schwaninger, Jens Alber, Bhagirath Chaurasia, Jan Mauer, Sophie M. Steculorum, Carola Förster, Julia Goldau, André Kleinridders, Sebastian Theurich, Maite Solas, Napoleone Ferrara, Alexander Jais, Brigitte Hampel, Gerard Karsenty, Jens C. Brüning, Sabine A. Eming
Publikováno v:
Cell, vol 165, iss 4
High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we demonstrate that HFD feeding of mice downregulates glucose transporter (GLUT)-1 expression in blood-brain barrier (BBB) vascular endothelial cells (BECs) and red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1529a404d795e816a3ab545a128ca55
https://doi.org/10.1016/j.cell.2016.03.033
https://doi.org/10.1016/j.cell.2016.03.033
Autor:
Jens C. Brüning, Jens Alber, Oliver Hahn, Celine E. Riera, Eva Tsaousidou, Jonathan Halloran, Kevin M. Tharp, Andreas Stahl, Hella S. Brönneke, Linda Engström Ruud, Courtney M. Anderson, Pereira Mma, Patricia Follett, Andrew Dillin, Brigitte Hampel, Filho Cdm
Publikováno v:
Yearbook of Paediatric Endocrinology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54fd13381a04640759d5e30ab950951c
https://doi.org/10.1530/ey.15.11.10
https://doi.org/10.1530/ey.15.11.10
Autor:
Hella S. Brönneke, Eva Tsaousidou, Martin Pal, Claudia M. Wunderlich, Jens C. Brüning, Peter Kloppenburg, F. Thomas Wunderlich, Bengt F. Belgardt, Marc Schmidt-Supprian, Lars Paeger, Brigitte Hampel, Ursel Collienne
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1495-1506 (2014)
SummaryActivation of c-Jun N-terminal kinase 1 (JNK1)- and inhibitor of nuclear factor kappa-B kinase 2 (IKK2)-dependent signaling plays a crucial role in the development of obesity-associated insulin and leptin resistance not only in peripheral tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c786e1afc78e5592ac3e4610592612a5
http://www.sciencedirect.com/science/article/pii/S2211124714009140
http://www.sciencedirect.com/science/article/pii/S2211124714009140
Autor:
Hella S. Brönneke, F. Thomas Wunderlich, Donald A. Morgan, Simon Hess, Sulay Tovar, Jens C. Brüning, A. Christine Hausen, P. Justus Ackermann, Nadine Evers, Hildegard Büning, Lars Paeger, Kamal Rahmouni, Brigitte Hampel, Peter Kloppenburg
Publikováno v:
Cell Metabolism
Cell Metabolism; Vol 18
Cell Metabolism; Vol 18
Summary Brown adipose tissue (BAT) is a critical regulator of glucose, lipid, and energy homeostasis, and its activity is tightly controlled by the sympathetic nervous system. However, the mechanisms underlying CNS-dependent control of BAT sympatheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934d18372f98443178b69712222d0c6b
Autor:
Xiaosong Ma, Pablo J. Enriori, C. Ronald Kahn, Chun Xu, Frances M. Ashcroft, Ruth Janoschek, Brigitte Hampel, Sabine D. Jordan, Eva Rother, Jens C. Brüning, A. Christine Könner, Gregory S. Barsh, Leona Plum, Michael A. Cowley
Publikováno v:
Monash University
SummaryInsulin action in the central nervous system regulates energy homeostasis and glucose metabolism. To define the insulin-responsive neurons that mediate these effects, we generated mice with selective inactivation of the insulin receptor (IR) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016b567d398a14c57e03151665e6b38
https://ora.ox.ac.uk/objects/uuid:e136f6b4-8c92-4ff2-8937-40894dd5d76e
https://ora.ox.ac.uk/objects/uuid:e136f6b4-8c92-4ff2-8937-40894dd5d76e
Autor:
Eva Tsaousidou, Bengt F. Belgardt, Brigitte Hampel, Ari Waisman, Eva Rother, Jens C. Brüning, Martin G. Myers
Publikováno v:
Proceedings of the National Academy of Sciences. 109:18132-18137
Rat insulin promoter (RIP)-expressing neurons in the hypothalamus control body weight and energy homeostasis. However, genetic approaches to study the role of these neurons have been limited by the fact that RIP expression is predominantly found in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8e01cc02af161fee302cad301bd761
https://doi.org/10.1073/pnas.1206147109
https://doi.org/10.1073/pnas.1206147109
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Autor:
Jeffrey M. Zigman, Tim Klöckener, Andreas Husch, Bradford B. Lowell, Jens C. Brüning, Linda A W Verhagen, Bengt F. Belgardt, Kevin W. Williams, Lars Paeger, Joel K. Elmquist, Tamas L. Horvath, Peter Kloppenburg, Jong Woo Sohn, Simon Hess, Harveen Dhillon, Brigitte Hampel
Publikováno v:
Nature Neuroscience; Vol 14
Nature neuroscience
Nature Neuroscience
Nature neuroscience
Nature Neuroscience
Steroidogenic factor 1 (SF-1)-expressing neurons of the ventromedial hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells remains undefined. We show that insulin activates phosphatidylinositol-3-OH kinase (PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f92ad996139439228bbe1c160ccb87d
https://doi.org/10.1038/nn.2847
https://doi.org/10.1038/nn.2847
Autor:
A. Christine Könner, Hella S. Brönneke, Carmen Sánchez-Lasheras, Simon Hess, Linda A W Verhagen, André Kleinridders, Peter Kloppenburg, Brigitte Hampel, Andrea Mesaros, Jens C. Brüning, Nadine Evers, Sulay Tovar
Publikováno v:
Cell Metabolism; Vol 13
Cell Metab
Cell Metab
Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cd0f9420835c04000f52c7baf25b88