Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brigitte Goulet"'
Publikováno v:
Biochemistry and Cell Biology. 90:22-38
Maspin, a member of the serpin family of serine protease inhibitors, was originally identified as a tumor suppressor that is expressed in normal mammary epithelial cells but is reduced or absent in breast carcinomas. Early enthusiasm for maspin as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edfd670329ce1a872bda07f07227eeb
https://doi.org/10.1139/o11-053
https://doi.org/10.1139/o11-053
Autor:
Ann F. Chambers, Alan B. Tuck, John D. Lewis, Carl O. Postenka, Joe S. Mymryk, Vincent Giguère, Wendy Kennette, M. Nicole Hague, Brigitte Goulet, Amber Ablack
Publikováno v:
ResearcherID
Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial. Maspin expression has been associated with a poor prognosis in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd64c798c9a461eb0ef722adf9f11980
https://doi.org/10.1038/labinvest.2011.66
https://doi.org/10.1038/labinvest.2011.66
Publikováno v:
Molecular Cancer Research. 6:644-653
Proteolytic processing by cathepsin L generates p110 Cut homeobox 1 (CUX1) at the end of the G1 phase, whereas an alternative transcript encodes p75 CUX1. These short CUX1 isoforms were reported to be overexpressed in cancer cells, and transgenic mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b431db3fbfe8383dc7d6f620e14db9
https://doi.org/10.1158/1541-7786.mcr-07-0268
https://doi.org/10.1158/1541-7786.mcr-07-0268
Publikováno v:
Biological Chemistry. 387:1285-1293
The Cut-like genes code for multiple isoforms of the CDP/Cux transcription factor. The full-length protein contains four DNA-binding domains: Cut repeats 1, 2 and 3 (CR1, CR2 and CR3) and the Cut homeodomain (HD). The p75 isoform is expressed from an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827f6d0bcd69663b0e930df7dc5c0c1a
https://doi.org/10.1515/bc.2006.159
https://doi.org/10.1515/bc.2006.159
Autor:
Jacynthe Laliberté, Claude Lazure, Sangeeta Pareek, Diane Savaria, Richard A. Murphy, Michel Chrétien, Suzanne Benjannet, Nabil G. Seidah, Brigitte Goulet, Josée Hamelin
Publikováno v:
ResearcherID
In order to define the enzymes responsible for the maturation of the precursor of nerve growth factor (proNGF), its biosynthesis and intracellular processing by the pro-protein convertases furin, PC1, PC2, PACE4, PC5 and the PC5 isoform PC5/6-B were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232247f8a0f5982cee404ea59ff4e448
https://doi.org/10.1042/bj3140951
https://doi.org/10.1042/bj3140951
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 90(1)
Maspin, a member of the serpin family of serine protease inhibitors, was originally identified as a tumor suppressor that is expressed in normal mammary epithelial cells but is reduced or absent in breast carcinomas. Early enthusiasm for maspin as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7f202f40e9367e14d6664dcd3c49805
https://pubmed.ncbi.nlm.nih.gov/22047058
https://pubmed.ncbi.nlm.nih.gov/22047058
Autor:
Matthew Bogyo, Lam Leduy, Shyam S. Chauhan, Alain Nepveu, Brigitte Goulet, Ekkehard Weber, Laurent Sansregret
Publikováno v:
Molecular cancer research : MCR. 5(9)
It is generally accepted that the role of cathepsin L in cancer involves its activities outside the cells once it has been secreted. However, cathepsin L isoforms that are devoid of a signal peptide were recently shown to be present in the nucleus wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224bb28ac2176a6f0be13ec2875092d9
https://pubmed.ncbi.nlm.nih.gov/17855659
https://pubmed.ncbi.nlm.nih.gov/17855659
Autor:
Jean-Bernard Denault, Alain Nepveu, Brigitte Goulet, Guy S. Salvesen, Lam Leduy, Mary Truscott
Publikováno v:
The Journal of biological chemistry. 282(41)
Proteolytic processing at the end of the G(1) phase generates a CUX1 isoform, p110, which functions either as a transcriptional activator or repressor and can accelerate entry into S phase. Here we describe a second proteolytic event that generates a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8d36867389b99d83aa1de70c18b9c4
https://pubmed.ncbi.nlm.nih.gov/17681953
https://pubmed.ncbi.nlm.nih.gov/17681953
Autor:
Lam Leduy, Ryoko Harada, Jacques Bertoglio, Alain Nepveu, Brian J. Wilson, Brigitte Goulet, Laurent Sansregret
The CDP/Cux transcription factor was previously found to acquire distinct DNA binding and transcriptional properties following a proteolytic processing event that takes place at the G1/S transition of the cell cycle. In the present study, we have inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95bd3606dfb40827a7fe2bb6596145a
https://europepmc.org/articles/PMC1430290/
https://europepmc.org/articles/PMC1430290/
Autor:
Brigitte Goulet, Alain Nepveu
Publikováno v:
Cell cycle (Georgetown, Tex.). 3(8)
An important mechanism of regulation that controls progression through the cell cycle involves the timely degradation of specific regulatory proteins. In parallel to the main degradative pathways, it appears that the function of certain proteins may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16abb8cc3131499261993ce5c5129ef5
https://pubmed.ncbi.nlm.nih.gov/15254406
https://pubmed.ncbi.nlm.nih.gov/15254406