Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Brigitte Gicquel"'
Autor:
Nils-Jørgen Knudsen Dal, Martin Speth, Kerstin Johann, Matthias Barz, Claire Beauvineau, Jens Wohlmann, Federico Fenaroli, Brigitte Gicquel, Gareth Griffiths, Noelia Alonso-Rodriguez
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughp
Externí odkaz:
https://doaj.org/article/ad046bb641e6403683ba9d4f8d557cee
Publikováno v:
Molecules, Vol 27, Iss 20, p 7130 (2022)
Tuberculosis remains an important cause of morbidity and mortality throughout the world. Notably, an important number of multi drug resistant cases is an increasing concern. This problem points to an urgent need for novel compounds with antimycobacte
Externí odkaz:
https://doaj.org/article/3f48157365ce47c49a261e76e4d08341
Autor:
Juan Manuel Coya, Laura De Matteis, Alexandre Giraud-Gatineau, Anne Biton, Inés Serrano-Sevilla, Anne Danckaert, Marie-Agnès Dillies, Brigitte Gicquel, Jesus M. De la Fuente, Ludovic Tailleux
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug
Externí odkaz:
https://doaj.org/article/9fbc80c8d30441f28f23553b171d6af4
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Autor:
Alexandre Giraud-Gatineau, Juan Manuel Coya, Alexandra Maure, Anne Biton, Michael Thomson, Elliott M Bernard, Jade Marrec, Maximiliano G Gutierrez, Gérald Larrouy-Maumus, Roland Brosch, Brigitte Gicquel, Ludovic Tailleux
Publikováno v:
eLife, Vol 9 (2020)
Antibiotics are widely used in the treatment of bacterial infections. Although known for their microbicidal activity, antibiotics may also interfere with the host’s immune system. Here, we analyzed the effects of bedaquiline (BDQ), an inhibitor of
Externí odkaz:
https://doaj.org/article/7742feb680244fcab351790b1c46fbe8
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis and represents one of the major challenges facing drug discovery initiatives worldwide. The considerable rise in bacterial drug resistance in recent years has led to the ne
Externí odkaz:
https://doaj.org/article/9d539ce22669430e9264ba01e6742a5a
Autor:
Ivan P. Nascimento, Dunia Rodriguez, Carina C. Santos, Eduardo P. Amaral, Henrique K. Rofatto, Ana P. Junqueira-Kipnis, Eduardo D. C. Gonçalves, Maria R. D’Império-Lima, Mario H. Hirata, Celio L. Silva, Nathalie Winter, Brigitte Gicquel, Kingston H. G. Mills, Mariagrazia Pizza, Rino Rappuoli, Luciana C. C. Leite
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressi
Externí odkaz:
https://doaj.org/article/df9d3306cb574c71b46f4ee32a1a4202
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Antibiotics can stimulate or depress gene expression in bacteria. The analysis of transcriptional responses of Mycobacterium to antimycobacterial compounds has improved our understanding of the mode of action of various drug classes and the efficacy
Externí odkaz:
https://doaj.org/article/65b953b883f2431da29084c117e5f40e
Autor:
Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson, Wenhong Zhang
Publikováno v:
Emerging Microbes and Infections, Vol 1, Iss 1, Pp 1-4 (2012)
Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide (PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance to PZA in MDR-TB is associated with poor treatment outcome, bacil
Externí odkaz:
https://doaj.org/article/dd3a953ee56a4f929c38f9f3556a62f4
Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil
Autor:
Silvana Spíndola de Miranda, Wânia da Silva Carvalho, Philip Noel Suffys, Afrânio Lineu Kritski, Martha Oliveira, Noemi Zarate, Thierry Zozio, Nalin Rastogi, Brigitte Gicquel
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 3, Pp 267-273 (2011)
We performed spoligotyping on 114 strains of the Mycobacterium tuberculosis (Mtb) complex that had been isolated from patients in Minas Gerais Health Units during 2004. A total of 82/114 (72%) clinical isolates were clustered and 32/114 (28%) were un
Externí odkaz:
https://doaj.org/article/19d1d27797864cb6936a826008109908
Autor:
Katherine J Siddle, Ludovic Tailleux, Matthieu Deschamps, Yong-Hwee Eddie Loh, Cécile Deluen, Brigitte Gicquel, Christophe Antoniewski, Luis B Barreiro, Laurent Farinelli, Lluís Quintana-Murci
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005064 (2015)
The optimal coordination of the transcriptional response of host cells to infection is essential for establishing appropriate immunological outcomes. In this context, the role of microRNAs (miRNAs)--important epigenetic regulators of gene expression-
Externí odkaz:
https://doaj.org/article/e25d9dc2459747f0b43e82398aa101a5