Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial

Autor: Ignace Vergote, Giovanni Scambia, David M O'Malley, Ben Van Calster, Sang-Yoon Park, Josep M del Campo, Werner Meier, Aristotelis Bamias, Nicoletta Colombo, Robert M Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R Kroep, Haijun Ma, Cheryl A Pickett, Bradley J Monk, Sang Yoon Park, Yong Sang Song, Yulia Makarova, Joshua Trinidad, Hextan Yuen Sheung Ngan, Gerasimos Aravantinos, Joo-Hyun Nam, Vera Gorbunova, Ludmila Krikunova, Duk-Soo Bae, Jose Angel Arranz Arija, Claudio Zamagni, Christos Papandreou, Francesco Raspagliesi, Alla Lisyanskaya, Ana Oaknin Benzaquen, Germana Tognon, Eugenia Ortega, Antonio Casado Herraez, Joseph Buscema, Andrew Green, Robert Burger, Dina Sakaeva, Andres Redondo Sanchez, Sharad Ghamande, Laurel King, Edgar Petru, Ulla Peen, Satoshi Takeuchi, Kimio Ushijima, Antonio Gonzalez Martin, Scott Kamelle, Michael Carney, Frédéric Forget, James Bentley, Jalid Sehouli, Paolo Zola, Hidenori Kato, Natalya Fadeeva, Evgeny Gotovkin, Vladimir Vladimirov, Margarita Romeo Marin, Eva Guerra Alia, Mark Shahin, Snehalkumar Bhoola, Krishnansu Tewari, Daniel Anderson, Brigitte Honhon, Joseph (Gino) Pelgrims, Amit Oza, Jesus Garcia-Donas Jimenez, Vincent Hansen, David O'Malley, Ivor Benjamin, Vincent Renard, Heidi Van den Bulck, Claudia Haenle, Georgios Koumakis, Harushige Yokota, Vadim Popov, William Bradley, Robert Wenham, Robert Reid, Donna McNamara, Richard Friedman, Joyce Barlin, Nicola Spirtos, Julia Chapman, Paul Sevelda, Manon Huizing, Caroline Lamot, Frédéric Goffin, Lionel D Hondt, Allan Covens, Silvana Spadafora, Beate Rautenberg, Toralf Reimer, Volker Möbus, Felix Hilpert, Martina Gropp-Meier, Antonella Savarese, Sandro Pignata, Francesco Verderame, Mika Mizuno, Hirokuni Takano, Petronella Ottevanger, Andres Poveda Velasco, Isabel Palacio-Vazquez, Amy Law, Kristi McIntyre, Michael Teneriello, Abbie Fields, Samuel Lentz, Daron Street, Benjamin Schwartz, Robert Mannel, Peter Lim, Heather Pulaski, Wolfgang Janni, Andreas Zorr, Ulrich Karck, Ashley Chi Kin Cheng, Roberto Sorio, Cesare Gridelli, Daisuke Aoki, Tetsuro Oishi, Yasuyuki Hirashima, Ingrid Boere, Esther Falco Ferrer, Patricia Braly, Sharon Wilks, Christine Lee, Jeanne Schilder, Dan Veljovich, Angeles Secord, Kevin Davis, Luis Rojas-Espaillat, Shashikant Lele, Stephen DePasquale, Robert Squatrito, Christian Schauer, Luc Dirix, Peter Vuylsteke, Eric Joosens, Diane Provencher, Hans-Joachim Lueck, Alexander Hein, Alexander Burges, Ulrich Canzler, Tjoung-Won Park-Simon, Frank Griesinger, Angiolo Gadducci, Oscar Alabiso, Aikou Okamoto, Takashi Sawasaki, Toshiaki Saito, Ana Herrero Ibañez, Coralia Calomeni, Monique Spillman, Janak Choksi, Nicholas Taylor, Carolyn Muller, David Moore, Paul DiSilvestro, Mary Cunningham, Peter Rose, Peter Oppelt, Didier Verhoeven, Marie-Pascale Graas, Prafull Ghatage, Katia Tonkin, Christian Kurzeder, Benjamin Schnappauf, Volkmar Müller, Hannah Schmalzrie, Haralambos Kalofonos, Milena Bruzzone, Judith Kroep, Cristina Caballero Diaz, Jeronimo Martinez Garcia, Susana Hernando Polo, Mitchell Garrison, Rodney Rocconi, Stephen Andrews, Robert Bristow, Michael McHale, Jack Basil, William Houck III, Maria Bell, Jonathan Cosin, Susan Modesitt, James Kendrick, James Wade III, Cheung Wong, Anthony Evans, Thomas Buekers, Timothy Vanderkwaak, James Ferriss, Christopher Darus, Stacy DAndre, Robert Higgins, Bradley Monk, Jamie Bakkum-Gamez, Leslie DeMars, Linda Van Le, Larry Puls, Shruti Trehan, James LaPolla, Elizabeth Dickson Michelson, Joseph Merchant, Christopher Peterson, Gary Reid, Donald Seago, Susan Zweizig, Walter Gajewski, Amit Panwalkar, Rudolf Leikermoser, Gerhard Bogner, Philip Debruyne, Randal D'hondt, Patrick Berteloot, Joseph Kerger, James Biagi, Vincent Castonguay, Stephen Welch, Aida Muhic, Martin Heubner, Eva-Maria Grischke, Brigitte Rack, Markus Fleisch, Florian Lordick, Dimitrios Pectasides, Wing Ming Ho, Luigi Selvaggi, Flavia Morales Vasquez, William Orlando Brito Villanueva, Alejandro Molina Alavez, Lonneke Kessels, Ana Santaballa Bertran, Cesar Mendiola Fernandez, Miguel Beltran Fabregat, Salvatore Del Prete, John Elkas, Gary Cecchi, Pallavi Kumar, Warner Huh, Mark Messing, Misagh Karimi, Ann Kelley, Babak Edraki, David Mutch, Gary Leiserowitz, Jeanne Anderson, Scott Lentz, Setsuko Chambers, Robert Morris, Steven Waggoner, Alan Gordon, Michael Method, Peter Johnson, Raymond Lord, Janet Drake, Kulumani Sivarajan, Madhu Midathada, Kristen Rice, Troy Wadsworth, James Pavelka, Robert Edwards, David Scott Miller, Patricia Locantore Ford, Jean Hurteau, David Bender, Veronica Schimp, William Creasman, Rachel Lerner, Donald Chamberlain, Angela Kueck, John McDonald, Salman Malad, Bernice Robinson-Bennett, Susan Davidson, Thomas Krivak, Timothy Lestingi, Hector Arango, Paul Berard, Karen Finkelstein, Rakesh Gaur, Carolyn Krasner, Frederick Ueland, Lance Talmage, Seiko Yamada, Gregory Sutton, Ronald Potkul, Monica Prasad-Hayes, Janet Osborne, Paul Celano, James Thigpen, Sudarshan Sharma, Russell Schilder, Jonathan Tammela, Mary Kemeny, Amy Brown, Eric Eisenhauer, James Williams, Kendrith Rowland, Kenneth Nahum, James Burke, Zahid Dar, Nicole Fleming, Randall Gibb, Alfred Guirguis, Thomas Herzog, Veena John, Santhosh Kumar, Aparna Kamat, Mohamad Kassar, Mario Leitao, Lyuba Levine, Luis Mendez, Dhimant Patel, Emily Berry, David Warshal, Judith Wolf, Corrine Zarwan, Yvonne Collins, Gary Spitzer, Brigitte Miller, Mark Einstein

Publikováno v: The Lancet Oncology, 20(6), 862-876. Lancet Publishing Group
The Lancet Oncology, 20(6), 862-876. ELSEVIER SCIENCE INC

BACKGROUND: Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has shown promise in the treatment of ovarian cancer. We aimed to assess whether tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64a9058d15a739010d9bb6ef9e6a7a8
https://hdl.handle.net/1887/122861

NRG Oncology/RTOG 0921: A phase 2 study of postoperative intensity-modulated radiotherapy with concurrent cisplatin and bevacizumab followed by carboplatin and paclitaxel for patients with endometrial cancer

Autor: Anuja Jhingran, Robert S. Mannel, Luis Souhami, Jennifer Moughan, Ursula A. Matulonis, William Small, Akila N. Viswanathan, Neil S. Horowitz, Brigitte Miller, Walter Bosch, Beth Erickson, Lorraine Portelance, David K. Gaffney, Kathryn Winter, Ying Xiao

Publikováno v: Cancer. 121:2156-2163

Purpose To assess acute and late adverse events (AEs), overall survival (OS), pelvic failure (PF), regional failure, distant failure, and disease-free survival (DFS) in a prospective phase II clinical trial of bevacizumab (Bev) and pelvic intensity m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66115298b24c56d822912a418a0c8331
https://doi.org/10.1002/cncr.29337

Hematologic Toxicity in RTOG 0418: A Phase 2 Study of Postoperative IMRT for Gynecologic Cancer

Autor: Mohammad Salehpour, Brigitte Miller, Jennifer Moughan, Luis Souhami, Lorraine Portelance, Anuja Jhingran, David D'Souza, Ann H. Klopp, R. Gaur, Jenny Nuanjing, Evangeline Hildebrandt, William Small

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 86:83-90

Purpose Intensity modulated radiation therapy (IMRT), compared with conventional 4-field treatment, can reduce the volume of bone marrow irradiated. Pelvic bone marrow sparing has produced a clinically significant reduction in hematologic toxicity (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944ef849f9eb5cd3548d0d65fbb75b3
https://doi.org/10.1016/j.ijrobp.2013.01.017

A phase II evaluation of weekly gemcitabine and docetaxel for second-line treatment of recurrent carcinosarcoma of the uterus: A gynecologic oncology group study

Autor: Frederick B. Stehman, Linda Van Le, William E. Richards, David P. Warshal, S. Diane Yamada, John A. Blessing, Brigitte Miller, Angeles Alvarez Secord, Ovadia Abulafia, Mark S. Shahin

Publikováno v: Gynecologic Oncology. 118:139-144

Background The objective of this study was to estimate antitumor activity and toxicity of weekly docetaxel and gemcitabine as second-line chemotherapy for patients with recurrent uterine carcinosarcoma. Methods Patients with recurrent carcinosarcoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69a4ad43659d5a94a6eda20527eac40
https://doi.org/10.1016/j.ygyno.2010.03.024

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

Autor: Martin D. Goodman, C. W. Helm, Brigitte Miller, Lynn P. Parker, Brian W. Loggie, Shesh N. Rai, Samuel S. Lentz, Richard A. Hoefer, Robert P. Edwards, Edward A. Levine, Scott D. Richard, Þ Jianmin Pan, David L. Bartlett, Daniel S. Metzinger, Paul H. Sugarbaker, James E. Spellman

Publikováno v: International Journal of Gynecological Cancer. 20:61-69

Introduction: An analysis of experience of surgical and gynecologic oncologists in the United States with the use of hyperthermic intraperitoneal chemotherapy for women with invasive epithelial ovarian cancer (EOC). Methods: An Internet-based registr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55b916bbdd93b60e49a646c0f691cca
https://doi.org/10.1111/igc.0b013e3181c50cde