Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Brigitte, Schombert"'
1
Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform
Autor: Brigitte Schombert, Michel Partiseti, G. Andrees Bohme, Camille Sanson, Bruno Filoche-Rommé
Publikováno v: Assay and Drug Development Technologies
Inwardly rectifying IK1 potassium currents of the heart control the resting membrane potential of ventricular cardiomyocytes during diastole and contribute to their repolarization after each action potential. Mutations in the gene encoding Kir2.1 cha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436f02d8e40d5ddbccdad38bf7627432
http://europepmc.org/articles/PMC6479253
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2
In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine
Autor: Céline Prévost, Eric Brohan, Odile Angouillant-Boniface, G.Andrees Böhme, Sylvie Houtmann, Céline Chantoiseau, Thierry Carriot, Veronique Ballet, Sophie Fouconnier, Laurent Schio, Michel Partiseti, Rachid Boukaiba, Jean-Marie Chambard, Brigitte Schombert
Publikováno v: European Journal of Pharmacology. 915:174670
Hydroxychloroquine (HCQ) is a derivative of the antimalaria drug chloroquine primarily prescribed for autoimmune diseases. Recent attempts to repurpose HCQ in the treatment of corona virus disease 2019 has raised concerns because of its propensity to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2889049ef9d687d5261e5fde9ce6f50
https://doi.org/10.1016/j.ejphar.2021.174670
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3
From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei
Autor: Rémy Béroud, Laurent Bialy, Andrees Bohme, Jean-Marie Chambard, Michel De Waard, Laetitia Lucarain, Lucie Jaquillard, Denis Servent, Stéphane Hourcade, Michel Partiseti, Gerhard Hessler, Stéphanie Combemale, Brigitte Schombert, Michael Kurz, Sophie Fouconnier, Rachid Boukaiba, Tânia C. Gonçalves, Evelyne Benoit
Publikováno v: Br J Pharmacol
British Journal of Pharmacology
British Journal of Pharmacology, Wiley, 2019, 176 (9), pp.1298-1314. ⟨10.1111/bph.14628⟩
British Journal of Pharmacology, 2019, 176 (9), pp.1298-1314. ⟨10.1111/bph.14628⟩
Background and purpose The NaV 1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process. We investigated a library prepared from original venoms of 117 different anim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6151b17071515a1356a1ceaedd9c4ca5
https://pubmed.ncbi.nlm.nih.gov/30784059
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4
Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel
Autor: Sylvie, Houtmann, Brigitte, Schombert, Camille, Sanson, Michel, Partiseti, G Andrees, Bohme
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1641
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1dfa2b5b9bdcba1f879048ab2311f37f
https://pubmed.ncbi.nlm.nih.gov/28748465
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5
Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel
Autor: Brigitte Schombert, Camille Sanson, Sylvie Houtmann, Michel Partiseti, G. Andrees Bohme
Publikováno v: Methods in Molecular Biology ISBN: 9781493971701
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45e8f3ed8fde6309183f950aa6abd7ff
https://doi.org/10.1007/978-1-4939-7172-5_10
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7
Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β-amyloid load
Autor: Charles Duyckaerts, Laurent Pradier, Nathalie Touchet, Luc Mercken, Nicolas Sergeant, André Delacourte, Gunter Tremp, Dominique Santiard-Baron, Dominique Langui, Benoît Delatour, Véronique Blanchard, Brigitte Schombert, Maryse Delehedde, Marie-Françoise Paul
Publikováno v: Journal of Neurochemistry. 93:330-338
FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP processing, signalling and be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d10d9748debebe820bedaac9aef76df
https://doi.org/10.1111/j.1471-4159.2005.03026.x
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8
Proteolytical processing of mutated human amyloid precursor protein in transgenic mice
Autor: Martine Mazadier, Michel Reibaud, Luc Mercken, Pia Delaere, Nathalie Touchet, Sylvie Dreisler, Gunter Tremp, Laurent Pradier, Manfred Theisen, Christian Czech, Anne Francoise Macq, Brigitte Schombert, Jean-Noël Octave, Konrad Beyreuther
Publikováno v: Molecular Brain Research. 47:108-116
The evidence that betaA4 is central to the pathology of Alzheimer's disease (AD) came from the identification of several missense mutations in the amyloid precursor protein (APP) gene co-segregating with familial AD (FAD). In an attempt to study the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8b790eeb3d4465d78b51804c5a4d01
https://doi.org/10.1016/s0169-328x(97)00039-9
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9
Expression of human FE65 in Amyloid Precursor Protein transgenic mice is associated with a reduction in beta-Amyloid load
Autor: Dominique, Santiard-Baron, Dominique, Langui, Maryse, Delehedde, Benoît, Delatour, Brigitte, Schombert, Nathalie, Touchet, Günter, Tremp, Marie-Françoise, Paul, Véronique, Blanchard, Nicolas, Sergeant, André, Delacourte, Charles, Duyckaerts, Laurent, Pradier, Luc, Mercken
Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2005, 93 (2), pp.330-8. ⟨10.1111/j.1471-4159.2005.03026.x⟩
International audience; FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::df336c40f6bdc94015305fe315ae694f
https://hal.archives-ouvertes.fr/hal-00173286
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10
Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures
Autor: M Lesort, B. Bonici, F. Terro, Saliha Moussaoui, N Carpentier, Véronique Blanchard, Christian Czech, A Takashima, Jacques Hugon, Brigitte Schombert, Laurent Pradier, S Dreisler, Gunter Tremp
Publikováno v: Neuroscience. 87(2)
Mutations in the gene for presenilin 1 are causative for the majority of cases of early onset familial Alzheimer's disease. Yet, the physiological function of presenilin 1 and the pathological mechanisms of the mutations leading to Alzheimer's diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0342a5fa8dfa49cc5ceec7fb9189f3d
https://pubmed.ncbi.nlm.nih.gov/9740395
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