Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brigitte, Maruschak"'
Autor:
Johanna Flach, Dieter Kube, Zuzanna Rydzynska, Gerburg M. Wulf, Bjoern Chapuy, Raphael Koch, Sabrina Becker, Ursula Sinzig, Andreas Leha, Brigitte Maruschak, Kamil Bojarczuk, Pablo Trigo-Mouriño, Christina Kiecke, Gerald Wulf, Christian Griesinger, Mateus de Oliveira Taveira, Sascha Dierks, Hanibal Bohnenberger, Holger Bastians, Vivek Venkataramani, Frederike von Bonin, Eva Schaefer, Lorenz Trümper, Lena Deuper
Publikováno v:
Molecular cancer research : MCR. 18(6)
Tightly regulated activity of the transcription factor MYC is essential for orderly cell proliferation. Upon deregulation, MYC elicits and promotes cancer progression. Proteasomal degradation is an essential element of MYC regulation, initiated by ph
Autor:
Shailender, Singh, Tobias, Dallenga, Anne, Winkler, Shanu, Roemer, Brigitte, Maruschak, Heike, Siebert, Wolfgang, Brück, Christine, Stadelmann
Publikováno v:
Journal of Neuroinflammation
Background Axonal damage and loss substantially contribute to the incremental accumulation of clinical disability in progressive multiple sclerosis. Here, we assessed the amount of Wallerian degeneration in brain tissue of multiple sclerosis patients
Publikováno v:
Kuhlmann, T, Remington, L, Maruschak, B, Owens, T & Brück, W 2007, ' Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions ', Journal of Neuropathology and Experimental Neurology, vol. 66, no. 3, pp. 238-46 . https://doi.org/10.1097/01.jnen.0000248559.83573.71
The unambiguous identification of oligodendrocytes in tissue sections, especially in myelinated tracts, is often difficult. Most of the antibodies used to identify oligodendrocytes label the myelin sheath as well. Originally described as an inhibitor
Autor:
Hans A. Kretzschmar, Brigitte Maruschak, Inga Zerr, Jochen Herms, Sigrid Poser, Henriette J. Tschampa, Ute Jastrow, Walter J. Schulz-Schaeffer, Otto Windl, Bernhard J. Steinhoff
Publikováno v:
Brain. 125:2558-2566
Summary The pathogenesis underlying the typical findings in Creutzfeldt‐Jakob disease (CJD) such as periodic EEG changes or myoclonus is not fully understood. The thalamus possesses a high density of inhibitory neurones and serves as a crucial pace
Publikováno v:
Journal of Neuroimmunology. 89:97-103
The effects of pentoxifylline (POX) on macrophage migration and myelin uptake were studied in an in vitro model of myelin phagocytosis. The POX is a phosphodiesterase inhibitor which inhibits TNF-alpha (tumor necrosis factor alpha) production and red
Publikováno v:
Acta Neuropathologica. 89:363-367
Monocytes/macrophages are important effector cells in myelin removal during Wallerian degeneration. Experiments with the mouse mutant C57BL/Ola revealed prolonged axonal survival and reduced phagocytic cell recruitment after nerve transsection. In th
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 53:51-60
The present study introduces an in vitro model of xenogeneic peripheral nerve rejection to analyze the role of macrophages in this complex immunological situation. Nerve-sensitized mouse peritoneal exudate cells were co-cultured with rat peripheral n
Autor:
Tanja, Kuhlmann, Uwe, Wendling, Christiane, Nolte, Frauke, Zipp, Brigitte, Maruschak, Christine, Stadelmann, Heike, Siebert, Wolfgang, Brück
Publikováno v:
Journal of neuroscience research. 67(2)
Macrophages/microglia are the key effector cells in myelin removal. Differences exist in the amount and time course of myelin uptake in the central (CNS) and peripheral nervous system (PNS), the basis of this difference, however, is not yet clarified
Publikováno v:
Brain research. 916(1-2)
Wallerian degeneration of a peripheral nerve is mainly characterized by axon and myelin degradation and is paralleled by a massive invasion of peripheral macrophages into the nerve. These cells enter the nerve attracted by a cascade of chemokines and