Time to evolve: predicting engineered T cell-associated toxicity with next-generation models

Autor: Emmanuel Donnadieu, Maik Luu, Miriam Alb, Brigitte Anliker, Silvia Arcangeli, Chiara Bonini, Biagio De Angelis, Rashmi Choudhary, David Espie, Anne Galy, Cam Holland, Zoltán Ivics, Chahrazade Kantari-Mimoun, Marie Jose Kersten, Ulrike Köhl, Chantal Kuhn, Bruno Laugel, Franco Locatelli, Ibtissam Marchiq, Janet Markman, Marta Angiola Moresco, Emma Morris, Helene Negre, Concetta Quintarelli, Michael Rade, Kristin Reiche, Matthias Renner, Eliana Ruggiero, Carmen Sanges, Hans Stauss, Maria Themeli, Jan Van den Brulle, Michael Hudecek, Monica Casucci

Publikováno v: Donnadieu, E, Luu, M, Alb, M, Anliker, B, Arcangeli, S, Bonini, C, de Angelis, B, Choudhary, R, Espie, D, Galy, A, Holland, C, Ivics, Z, Kantari-Mimoun, C, Kersten, M J, Köhl, U, Kuhn, C, Laugel, B, Locatelli, F, Marchiq, I, Markman, J, Moresco, M A, Morris, E, Negre, H, Quintarelli, C, Rade, M, Reiche, K, Renner, M, Ruggiero, E, Sanges, C, Stauss, H, Themeli, M, van den Brulle, J, Hudecek, M & Casucci, M 2022, ' Time to evolve : predicting engineered T cell-associated toxicity with next-generation models ', Journal for Immunotherapy of Cancer, vol. 10, no. 5 . https://doi.org/10.1136/jitc-2021-003486

Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cc85efcc512b0862576aa25238c06f
https://pubmed.ncbi.nlm.nih.gov/35577500

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach

Autor: Michael Bachmann, Stefan B. Eichmüller, Matthias Renner, Gerald Willimsky, Brigitte Anliker, Winfried S. Wels, Michael Schmitt, Angela M. Krackhardt, Martina Schüssler-Lenz, Dirk M. Nettelbeck, Martin Hildebrandt, Lutz Uharek

Publikováno v: Cancer Immunology, Immunotherapy. 67:513-523

Adoptive transfer of T cells genetically modified by TCRs or CARs represents a highly attractive novel therapeutic strategy to treat malignant diseases. Various approaches for the development of such gene therapy medicinal products (GTMPs) have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8e189d9a5299d13654beeb3fb2d23c
https://doi.org/10.1007/s00262-018-2119-y

Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

Autor: Brigitte Anliker, Richard Rivera, Ji Woong Choi, Shannon E. Gardell, Mu-En Lin, Jerold Chun, Grace Kennedy

Publikováno v: Glia. 61:2009-2022

Schwann cell (SC) migration is an important step preceding myelination and remyelination in the peripheral nervous system, and can be promoted by peptide factors like neuregulins. Here we present evidence that a lipid factor, lysophosphatidic acid (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a78d56cdbfb526a048ce14234b802696
https://doi.org/10.1002/glia.22572

[Therapeutic approaches using genetically modified cells]

Autor: Brigitte, Anliker, Matthias, Renner, Matthias, Schweizer

Publikováno v: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 58(11-12)

Medicinal products containing genetically modified cells are, in most cases, classified as gene therapy and cell therapy medicinal products. Although no medicinal product containing genetically modified cells has been licensed in Europe yet, a variet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c368134bd26edf2ca00753ed664e0e42
https://pubmed.ncbi.nlm.nih.gov/26349563

Tenascin-R inhibits regrowth of optic fibers in vitro and persists in the optic nerve of mice after injury

Autor: Joanne Taylor, Melitta Schachner, Catherina G. Becker, Udo Bartsch, Brigitte Anliker, Thomas Becker, Ronald L. Meyer

Publikováno v: Glia. 29:330-346

Tenascin-R, an extracellular matrix constituent expressed by oligodendrocytes and some neuronal cell types, may contribute to the inhibition of axonal regeneration in the adult central nervous system. Here we show that outgrowth of embryonic and adul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90948cbb76f0c353005aa1f0221e2473
https://doi.org/10.1002/(sici)1098-1136(20000215)29:4<330::aid-glia4>3.0.co