Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Brigida Santos"'
Autor:
Guisou Zarbalian, Emmanuela E. Ambrose, Mohamed Cherif Rahimy, Hassan Ghazal, Léon Tshilolo, Michael S. Watson, Karim Ouldim, Brigida Santos, Obiageli E Nnodu, Careema Yusuf, Russell E. Ware, Amina Barkat, Michele A. Lloyd-Puryear, Charles Kiyaga, Kwaku Ohene-Frempong, Bradford L. Therrell, Tisungane Mvalo, Carmencita D. Padilla
Publikováno v:
J Community Genet
In an effort to explore new knowledge and to develop meaningful collaborations for improving child health, the First Pan African Workshop on Newborn Screening was convened in June 2019 in Rabat, Morocco. Participants included an informal network of n
Hydroxyurea reduces the transfusion burden in children with sickle cell anemia: the reach experience
Autor:
Alexandra Power-Hays, George A. Tomlinson, Leon Tshilolo, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Patrick T. McGann, Banu Aygun, Adam Lane, Susan E. Stuber, Teresa Latham, Russell E. Ware
Publikováno v:
American Society of Hematology Annual Scientifc conference
Introduction: Many children with sickle cell anemia (SCA) require blood transfusions, which carry risks and utilize a scarce resource globally, particularly in Africa. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, NCT01966731) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffae011d2bd52494469c08ea124c95ce
http://hdl.handle.net/10044/1/99893
http://hdl.handle.net/10044/1/99893
Autor:
Mariana Delgadinho, Catarina Ginete, Brígida Santos, Jocelyne Neto de Vasconcelos, Ana Paula Arez, Miguel Brito
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7258 (2024)
Parasitic infections are a common problem in developing countries and can intensify morbidity in patients with sickle cell disease (SCD), increasing the severity of anemia and the need for transfusions. It has been demonstrated that both helminths an
Externí odkaz:
https://doaj.org/article/9f3245b2f52e45eea9438121e6f5c61f
Autor:
António Armando, Rui Pascoal, Halimat Shadia Olaniyan, Patrick T. McGann, Christine Briscoe, Brigida Santos
Publikováno v:
Blood. 138:913-913
Background: Sickle cell disease (SCD) is among the most common, lethal and poorly recognized diseases globally. Over 300,000 children are born each year with SCA and most die by five years, primarily due to the lack of timely and accurate diagnosis.
Autor:
Maria Nakafeero, Russell E. Ware, Susan E. Stuber, Peter Olupot-Olupot, Patrick T. McGann, George Tomlinson, Léon Tshilolo, Janet Adams, Adam Lane, Brigida Santos, Banu Aygun, Thomas N. Williams, Teresa Latham
Publikováno v:
Blood. 136:17-18
Introduction: Transcranial Doppler (TCD) screening data from Uganda, Tanzania, and Nigeria have documented elevated velocities in >20% of children with sickle cell anemia (SCA) not receiving hydroxyurea treatment. Realizing Effectiveness Across Conti
Autor:
Jasmine Baker, Jonathan M. Flanagan, Thomas N. Williams, Brigida Santos, George Tomlinson, Russell E. Ware, Rosa M. Nieves, Adam Lane, Kathryn L McElhinney, Teresa Latham, Susan E. Stuber, Peter Olupot-Olupot, Anu Marahatta, Nicole A. Mortier, William H. Schultz, Angela Rankine-Mullings, Thad A. Howard, Patrick T. McGann, Marvin Reid, Rafael Mena, Banu Aygun, Robert O. Opoka, Léon Tshilolo, Chandy C. John
Publikováno v:
Blood. 136:8-9
Introduction: Hydroxyurea is a potent therapeutic agent for sickle cell anemia (SCA), and treatment at maximum tolerated dose (MTD) is becoming the standard of care. Hydroxyurea exerts its disease-modifying effects primarily through induction of feta
Autor:
Susan E. Stuber, Kathryn L McElhinney, Anu Marahatta, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Rafael Mena, Chandy C. John, Jasmine Baker, Robert O. Opoka, Léon Tshilolo, Thad A. Howard, Rosa M. Nieves, Russell E. Ware, Teresa Latham, Jonathan M. Flanagan
Publikováno v:
Blood. 136:33-34
Introduction: Elevated levels of fetal hemoglobin (HbF) are known to ameliorate both the morbidity and mortality of sickle cell anemia (SCA). Sustained post-natal HbF expression is heritable and regulated by multiple quantitative trait loci. Previous
Akademický článek
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Autor:
Catarina Ginete, Mariana Delgadinho, Brígida Santos, Armandina Miranda, Carina Silva, Paulo Guerreiro, Emile R. Chimusa, Miguel Brito
Publikováno v:
Genes, Vol 15, Iss 4, p 469 (2024)
The aim of this study was to identify genetic markers in the HBB Cluster; HBS1L-MYB intergenic region; and BCL11A, KLF1, FOX3, and ZBTB7A genes associated with the heterogeneous phenotypes of Sickle Cell Anemia (SCA) using next-generation sequencing,
Externí odkaz:
https://doaj.org/article/caf4b5b5deba4c5f8018be284102a8aa
Autor:
Patrick T. McGann, Banu Aygun, Susan E. Stuber, Thomas N. Williams, Adam Lane, Russell E. Ware, Peter Olupot-Olupot, Brigida Santos, George Tomlinson, Léon Tshilolo, Teresa Latham
Publikováno v:
Blood. 136:17-17
Introduction: Realizing Effectiveness Across Continents with Hydroxyurea (REACH, NCT01966731) is an open-label study of hydroxyurea for children with sickle cell anemia (SCA) in sub-Saharan Africa (Angola, DR Congo, Kenya, and Uganda). Initial result