Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Brigid M Hoey"'
Autor:
John Butler, Nicolaas J. del Mol, Lambert H.M. Janssen, Klaas J. Lusthof, David N. Reinhoudt, Willem Verboom, Wilma Richter, Brigid M Hoey
Publikováno v:
Free radical biology and medicine, 13(6), 599-608. Elsevier
The formation of reactive oxygen intermediates (ROI) during redox cycling of newly synthesized potential antitumor 2,5-bis (1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives has been studied by assaying the production of ROI (superoxide, hydroxyl rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b355aaf999c8d7862df107bfeab7bf
https://doi.org/10.1016/0891-5849(92)90034-e
https://doi.org/10.1016/0891-5849(92)90034-e
Autor:
John F. Smyth, Jeffrey Cummings, Ian D. Hickson, Gordon A. Leonard, Brigid M Hoey, Andrew M. Fry, Martin A. Graham, John Butler, Raymond C. French
Publikováno v:
Biochemical Pharmacology. 44:433-439
GR63178A (NSC D611615) is the second pentacyclic pyrolloquinone to be evaluated clinically as an anticancer drug. Its mechanism of action is unknown but may be related either to its quinone group or planar ring system. In this report we have investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d47de97e25da97513f73e079eea047
https://doi.org/10.1016/0006-2952(92)90433-j
https://doi.org/10.1016/0006-2952(92)90433-j
Autor:
Andrew S. Thompson, Brigid M Hoey, Mark D. Berardini, John A. Hartley, David E. Thurston, Mauro Ponti, Neil W. Gibson, John Butler
Publikováno v:
Biochemistry. 30:11719-11724
Several bifunctional alkylating agents of the aziridinylbenzoquinone class have been evaluated as potential antitumor agents. 3,6-Bis[(2-hydroxyethyl)amino]-2,5- diaziridinyl-1,4-benzoquinone (BZQ), 2,5-diaziridinyl-1,4-benzoquinone (DZQ), 3,6-bis(ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef9805124c67d8db4f798622721399d
https://doi.org/10.1021/bi00114a016
https://doi.org/10.1021/bi00114a016
Publikováno v:
Carcinogenesis. 14(4)
The effect of exposure to whole-body gamma-irradiation or fast electrons on O6-alkylguanine-DNA-alkyltransferase (ATase) activity and mRNA abundance has been examined in mice. In response to gamma-radiation, hepatic ATase activity was significantly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b9af919353a8ba96800150908db45d
https://pubmed.ncbi.nlm.nih.gov/8472332
https://pubmed.ncbi.nlm.nih.gov/8472332
Autor:
Brigid M Hoey, John Butler
Publikováno v:
Biochimica et biophysica acta. 1161(1)
The rates of reduction of 27 compounds by purified cytochrome P-450 reductase have been studied and correlated with the one-electron reduction potentials E7(X/X.-). For compounds with reduction potentials between approx. -400 and -165 mV, there was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8491ad57ac314b3487d83d93093ef1c4
https://pubmed.ncbi.nlm.nih.gov/8380722
https://pubmed.ncbi.nlm.nih.gov/8380722
Autor:
Brigid M Hoey, John Butler
Publikováno v:
Free radical biologymedicine. 12(5)
The reactions of glutathione (GSH) and glutathione radicals with a series of methyl-substituted 1,4-benzoquinones and 1,4-benzoquinone have been studied. It was found that by mixing excess benzoquinone with glutathione at pH above 6.5, the products f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6343a25ea7cb39dc0935699d0d34c1
https://pubmed.ncbi.nlm.nih.gov/1592273
https://pubmed.ncbi.nlm.nih.gov/1592273
Publikováno v:
Free radical research communications. 8(4-6)
The mechanisms of cytotoxicity of the antitumour diaziridinylbenzoquinones, AZQ and BZQ. have been investigated. HPLC analysis has been used to study the products as well as the rate of decomposition of acid-assisted ring-opening in aqueous medium as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30b4b0d47551e5b8280a462f7146b59
https://pubmed.ncbi.nlm.nih.gov/2162311
https://pubmed.ncbi.nlm.nih.gov/2162311
Publikováno v:
Biochemical Pharmacology. 36:3345-3351
The anthrapyrazole CI941 is one of a new series of DNA complexing drugs which displays high level broad spectrum antitumour activity in mice. In view of the proposed role of drug free radical formation, Superoxide generation and lipid peroxidation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90769c0bc29c6e1245bf164ffb95112d
https://doi.org/10.1016/0006-2952(87)90309-1
https://doi.org/10.1016/0006-2952(87)90309-1
Publikováno v:
Biochemical Pharmacology. 36:3739-3742
Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23310d9144a7548a2ce092a9fa730049
https://doi.org/10.1016/0006-2952(87)90028-1
https://doi.org/10.1016/0006-2952(87)90028-1
Publikováno v:
Free Radical Biology and Medicine. 6:593-597
N-acetylcysteine has been widely used as an antioxidant in vivo and in vitro. Its reaction with four oxidant species has therefore been examined. N-acetylcysteine is a powerful scavenger of hypochlorous acid (HOCl); low concentrations are able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385b8818027e4bfeb099622b6b00bda
https://doi.org/10.1016/0891-5849(89)90066-x
https://doi.org/10.1016/0891-5849(89)90066-x