Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brigid K Jensen"'
Autor:
Brigid K Jensen, Martin H Schuldi, Kevin McAvoy, Katelyn A Russell, Ashley Boehringer, Bridget M Curran, Karthik Krishnamurthy, Xinmei Wen, Thomas Westergard, Le Ma, Aaron R Haeusler, Dieter Edbauer, Piera Pasinelli, Davide Trotti
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
Abstract The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐a
Externí odkaz:
https://doaj.org/article/2b844e943b33490cb8b38258496834ea
Autor:
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Shashirekha S. Markandaiah, Brigid K. Jensen, Karthik Krishnamurthy, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Translation of the hexanucleotide G4C2 expansion associated with C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is ye
Externí odkaz:
https://doaj.org/article/19ca21d95d3242fdb4694723b5e2de9e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease that leads to the death of motor and cortical neurons. The clinical manifestations of ALS are heterogenous, and efficacious treatments to significantly slow the pro
Externí odkaz:
https://doaj.org/article/a6ee59e3606b42deaacd5ea9fd863073
Autor:
Brigid K. Jensen, Kevin J. McAvoy, Nicolette M. Heinsinger, Angelo C. Lepore, Hristelina Ilieva, Aaron R. Haeusler, Davide Trotti, Piera Pasinelli
Publikováno v:
Glia. 70:1426-1449
Genetic mutations that cause amyotrophic lateral sclerosis (ALS), a progressively lethal motor neuron disease, are commonly found in ubiquitously expressed genes. In addition to direct defects within motor neurons, growing evidence suggests that dysf
Autor:
Thomas Westergard, Brigid K. Jensen, Xinmei Wen, Jingli Cai, Elizabeth Kropf, Lorraine Iacovitti, Piera Pasinelli, Davide Trotti
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 645-652 (2016)
Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat-associated non-ATG tr
Externí odkaz:
https://doaj.org/article/2e4fc1c1a2374d1da63375d78adcbdcb
Autor:
Brigid K. Jensen, Jonathan D. Geiger, Lindsay M Roth, Judith B. Grinspan, Lindsay Festa, Kelly L. Jordan-Sciutto
Publikováno v:
J Neuroimmune Pharmacol
Despite the introduction of antiretroviral (ARV) therapy (ART), approximately 30-50% of people living with human immunodeficiency virus-1 (HIV-1) will develop a spectrum of measurable neurocognitive dysfunction, collectively called HIV-associated neu
Autor:
Piera Pasinelli, Aaron R. Haeusler, Nicolette M. Heinsinger, Davide Trotti, Brigid K. Jensen, Hristelina Ilieva, Angelo C. Lepore, Kevin McAvoy
Genetic mutations that cause Amyotrophic Lateral Sclerosis (ALS), a progressively lethal motor neuron disease, are commonly found in ubiquitously expressed genes. In addition to direct defects within motor neurons, growing evidence suggests that dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09d606802a39619eb4402381c4d0691
https://doi.org/10.1101/2021.11.23.469650
https://doi.org/10.1101/2021.11.23.469650
Publikováno v:
Journal of Visualized Experiments.
Before neuronal degeneration, the cause of motor and cognitive deficits in patients with amyotrophic lateral sclerosis (ALS) and/or frontotemporal lobe dementia (FTLD) is dysfunction of communication between neurons and motor neurons and muscle. The
Autor:
Katelyn Russell, Ashley Boehringer, Dieter Edbauer, Kevin McAvoy, Brigid K. Jensen, Thomas Westergard, Bridget M. Curran, Le Ma, Martin H Schuldi, Piera Pasinelli, Xinmei Wen, Karthik Krishnamurthy, Aaron R. Haeusler, Davide Trotti
Publikováno v:
EMBO molecular medicine 12(5), e10722 (2020). doi:10.15252/emmm.201910722
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73196be2a6ddf0e1abed144a6614902a
Autor:
Elizabeth Kropf, Jingli Cai, Brigid K. Jensen, Piera Pasinelli, Thomas Westergard, Lorraine Iacovitti, Davide Trotti, Xinmei Wen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 645-652 (2016)
SummaryAberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat-associated non