Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Brigid, Ryan"'
1
Akademický článek
A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
Autor: Maize C. Cao, Brigid Ryan, Jane Wu, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Emma L. Scotter
Publikováno v: Neurobiology of Disease, Vol 185, Iss , Pp 106245- (2023)
TDP-43 dysfunction is a molecular hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A major hypothesis of TDP-43 dysfunction in disease is the loss of normal nuclear function, resulting in impaired RNA regulation and
Externí odkaz: https://doaj.org/article/8e5f99125ab542caac7f334399448b57
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2
Akademický článek
Dementia prevalence estimation among the main ethnic groups in New Zealand: a population-based descriptive study of routinely collected health data
Autor: Amy Hai Yan Chan, Brigid Ryan, Sarah Cullum, Gary Cheung, Claudia Rivera-Rodriguez, Etuini Ma’u, Edith To
Publikováno v: BMJ Open, Vol 12, Iss 9 (2022)
Objective Estimates of dementia prevalence in New Zealand (NZ) have previously been extrapolated from limited Australasian studies, which may be neither accurate nor reflect NZ’s unique population and diverse ethnic groups. This study used routinel
Externí odkaz: https://doaj.org/article/31050602ddc34ef6a29fa330a61220f8
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3
Akademický článek
Impact of COVID-19 on the health and psychosocial status of vulnerable older adults: study protocol for an observational study
Autor: Gary Cheung, Claudia Rivera-Rodriguez, Adrian Martinez-Ruiz, Etuini Ma’u, Brigid Ryan, Vanessa Burholt, Ange Bissielo, Brigette Meehan
Publikováno v: BMC Public Health, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Many countries around the world have adopted social distancing as one of the public health measures to reduce COVID-19 transmissions in the community. Such measures could have negative effects on the mental health of the populatio
Externí odkaz: https://doaj.org/article/bd5e7026374944aa9a9b520f995f7c9e
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4
Akademický článek
Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis
Autor: Molly E. V. Swanson, Emma L. Scotter, Leon C. D. Smyth, Helen C. Murray, Brigid Ryan, Clinton Turner, Richard L. M. Faull, Mike Dragunow, Maurice A. Curtis
Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract In Alzheimer’s disease (AD), microglia are affected by disease processes, but may also drive pathogenesis. AD pathology-associated microglial populations have been identified with single-cell RNA-Seq, but have not been validated in human b
Externí odkaz: https://doaj.org/article/fd4bdb9a974b40289fbe32b437cd3db9
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5
Akademický článek
RNA Quality in Post-mortem Human Brain Tissue Is Affected by Alzheimer’s Disease
Autor: Blake Highet, Remai Parker, Richard L. M. Faull, Maurice A. Curtis, Brigid Ryan
Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)
Gene expression studies of human post-mortem brain tissue are useful for understanding the pathogenesis of neurodegenerative disease. These studies rely on the assumption that RNA quality is consistent between disease and neurologically normal cases;
Externí odkaz: https://doaj.org/article/bc61532a296142d095955929627b6878
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7
PSA-NCAM Regulatory Gene Expression Changes in the Alzheimer’s Disease Entorhinal Cortex Revealed with Multiplexed in situ Hybridization
Autor: Blake Highet, James A. Wiseman, Hannah Mein, Remai Parker, Brigid Ryan, Clinton P. Turner, Yu Jing, Malvindar K. Singh-Bains, Ping Liu, Mike Dragunow, Richard L.M. Faull, Helen C. Murray, Maurice A. Curtis
Publikováno v: Journal of Alzheimer's Disease. 92:371-390
Background: Alzheimer’s disease (AD) is the most common form of dementia and is characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated that neurons involved in memory function may lose plasticity because of decr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21a9122f891d15d94caec53061fb4178
https://doi.org/10.3233/jad-220986
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8
Prevalence of young-onset dementia: nationwide analysis of routinely collected data
Autor: Brigid Ryan, Edith To, Etuini Ma'u, Amy Hai Yan Chan, Claudia Rivera-Rodriguez, Maurice A Curtis, Sarah Cullum, Gary Cheung
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 93:1066-1073
IntroductionYoung-onset dementia prevalence is understudied internationally. Previous studies have been limited by low case numbers, reliance on single sources of routinely collected health data for case identification and inclusion of a limited age
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f29527b5768999f749020a0b1ae1778
https://doi.org/10.1136/jnnp-2022-329126
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10
Incidence of Young Onset Dementia in Waikato, New Zealand: A Population-Based Study
Autor: Lochanie Fonseka, David Wang, Brigid Ryan, Gary Cheung, Etuini Ma’u
Publikováno v: Journal of Alzheimer's disease : JAD. 90(3)
Background: There is limited epidemiological research on the incidence of young onset dementia (YOD). Estimates of YOD incidence in New Zealand are extrapolated from international studies that do not reflect New Zealand’s population and ethnic dive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb37e748e130ad8be3a9e7b169556653
https://pubmed.ncbi.nlm.nih.gov/36245382
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