Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Bright N Okine"'
Publikováno v:
Molecules, Vol 27, Iss 6, p 2021 (2022)
There is evidence for the involvement of peroxisome proliferator-activated receptors (PPARs) in pain, cognition, and anxiety. However, their role in pain–fear interactions is unknown. The amygdala plays a key role in pain, conditioned fear, and fea
Externí odkaz:
https://doaj.org/article/b2309c9557714a3d8870f659572e81c8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 129, Iss , Pp 110456- (2020)
Background: Modulation of the endocannabinoid system has been shown to alleviate neuropathic pain. The aim of this study was to evaluate if treatment with paclitaxel, a chemotherapeutic agent that induces neuropathic pain, affects endocannabinoid lev
Externí odkaz:
https://doaj.org/article/6fc6c4a155c44e4d86dfc0b040291617
Publikováno v:
Molecules, Vol 25, Iss 4, p 1007 (2020)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPARα, PPARβ/δ, PPARγ) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear interactions has not yet be
Externí odkaz:
https://doaj.org/article/6d0f367e1e4143ceb7cb26d4fbbbbf40
Autor:
Kim I. Chisholm, Martyn G Jones, Joseph O Lloyd, Giorgio Lambru, Adnan Al-Kaisy, Beatrice Oehle, Bright N Okine, Anna P. Andreou, Stephen B. McMahon
Publikováno v:
Neurotherapeutics
Single-pulse transcranial magnetic stimulation (sTMS) of the occipital cortex is an effective migraine treatment. However, its mechanism of action and cortical effects of sTMS in migraine are yet to be elucidated. Using calcium imaging and GCaMP-expr
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 129, Iss, Pp 110456-(2020)
Background Modulation of the endocannabinoid system has been shown to alleviate neuropathic pain. The aim of this study was to evaluate if treatment with paclitaxel, a chemotherapeutic agent that induces neuropathic pain, affects endocannabinoid leve
Publikováno v:
Molecules
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 1007 (2020)
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 1007 (2020)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR&alpha
PPAR&beta
/&delta
PPAR&gamma
) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pa
PPAR&beta
/&delta
PPAR&gamma
) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2854d878180cf85a3067c7d4865a4cac
http://hdl.handle.net/10379/16257
http://hdl.handle.net/10379/16257
Autor:
Juliana R Bastos, David P. Finn, Bright N. Okine, Pedro H. Gobira, Fabiola M. Ribeiro, Edleusa M. L. Batista, Fabrício A. Moreira, A.C. Issy, Elaine Aparecida Del Bel, Vivian T. da Silveira, Julia A.S. Gomes, Antonio C. de Oliveira, Ana Maria Hermeto Camilo de Oliveira, Daniele C. Aguiar, Laila Asth
Publikováno v:
British Journal of Pharmacology. 176:1541-1551
Background and purpose The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) bind to CB1 and CB2 cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs,
Publikováno v:
British Journal of Pharmacology. 176:1421-1442
Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant advers
Autor:
Michelle Roche, Kieran Rea, Bright N. Okine, David P. Finn, Manish K. Madasu, Weredeselam M. Olango, Róisín Lenihan
Publikováno v:
Pharmacological Research. 113:44-54
Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, anxiety/depressive-like phenotype
Autor:
Brendan Harhen, Gemma Mc Laughlin, Bright N. Okine, Jessica C. Gaspar, David P. Finn, Michelle Roche
Publikováno v:
Neuroscience. 443
The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, the present study tested the