Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Brigham J. Hartley"'
Autor:
Benjamin Readhead, Brigham J. Hartley, Brian J. Eastwood, David A. Collier, David Evans, Richard Farias, Ching He, Gabriel Hoffman, Pamela Sklar, Joel T. Dudley, Eric E. Schadt, Radoslav Savić, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Unbiased large scale screening of small molecules for drug discovery in psychiatric disease is technically challenging and financially costly. Here, Readhead and colleagues integrate in silico and in vitro approaches to design and conduct transcripto
Externí odkaz:
https://doaj.org/article/ed2d9e5658de4fa6b0313e02ddefca0f
Autor:
Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from pati
Externí odkaz:
https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
Autor:
Julia TCW, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 600-614 (2017)
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes f
Externí odkaz:
https://doaj.org/article/0a159cb0a6f94d45b780e4a99f4ce885
Autor:
Seok-Man Ho, Brigham J. Hartley, Erin Flaherty, Prashanth Rajarajan, Rawan Abdelaal, Ifeanyi Obiorah, Natalie Barretto, Hamza Muhammad, Hemali P. Phatnani, Schahram Akbarian, Kristen J. Brennand
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 615-628 (2017)
Summary: Modulation of transcription, either synthetic activation or repression, via dCas9-fusion proteins is a relatively new methodology with the potential to facilitate high-throughput up- or downregulation studies of gene function. Genetic studie
Externí odkaz:
https://doaj.org/article/2772a37d93fb404291498f59170646ce
Autor:
Aaron Topol, Shijia Zhu, Brigham J. Hartley, Jane English, Mads E. Hauberg, Ngoc Tran, Chelsea Ann Rittenhouse, Anthony Simone, Douglas M. Ruderfer, Jessica Johnson, Ben Readhead, Yoav Hadas, Peter A. Gochman, Ying-Chih Wang, Hardik Shah, Gerard Cagney, Judith Rapoport, Fred H. Gage, Joel T. Dudley, Pamela Sklar, Manuel Mattheisen, David Cotter, Gang Fang, Kristen J. Brennand
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 1024-1036 (2016)
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control neural progenitor cells (NPCs) but also significantly downregulated in a s
Externí odkaz:
https://doaj.org/article/b0003f0400fd429886636eb3927af61c
Autor:
Benjamin Readhead, Brigham J. Hartley, Brian J. Eastwood, David A. Collier, David Evans, Richard Farias, Ching He, Gabriel Hoffman, Pamela Sklar, Joel T. Dudley, Eric E. Schadt, Radoslav Savić, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted ‘Sema4, a Mount Sinai venture, Stamford, Connecticut, USA’. This has been corrected in both the PDF and HTML ve
Externí odkaz:
https://doaj.org/article/3227bb526fa5470faaa78282bcab2933
Autor:
Aaron Topol, Shijia Zhu, Brigham J. Hartley, Jane English, Mads E. Hauberg, Ngoc Tran, Chelsea Ann Rittenhouse, Anthony Simone, Douglas M. Ruderfer, Jessica Johnson, Ben Readhead, Yoav Hadas, Peter A. Gochman, Ying-Chih Wang, Hardik Shah, Gerard Cagney, Judith Rapoport, Fred H. Gage, Joel T. Dudley, Pamela Sklar, Manuel Mattheisen, David Cotter, Gang Fang, Kristen J. Brennand
Publikováno v:
Cell Reports, Vol 20, Iss 10, p 2525 (2017)
Externí odkaz:
https://doaj.org/article/836e8f01340a4449b1b36d2132d25624
Autor:
Aeson Chang, Edoardo Botteri, Ryan D. Gillis, Lukas Löfling, Caroline P. Le, Alexandra I. Ziegler, Ni-Chun Chung, Matthew C. Rowe, Stewart A. Fabb, Brigham J. Hartley, Cameron J. Nowell, Sasagu Kurozumi, Sara Gandini, Elisabetta Munzone, Emilia Montagna, Nina Eikelis, Sarah E. Phillips, Chikako Honda, Kei Masuda, Ayaka Katayama, Tetsunari Oyama, Steve W. Cole, Gavin W. Lambert, Adam K. Walker, Erica K. Sloan
Publikováno v:
Science Translational Medicine. 15
Beta-adrenergic blockade has been associated with improved cancer survival in patients with triple-negative breast cancer (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd3f0b627f0e271b4aeb89aa199bd51
https://doi.org/10.1126/scitranslmed.adf1147
https://doi.org/10.1126/scitranslmed.adf1147
Autor:
Brian A. Rodriguez, Jason P. Weick, Michela Dell'Orco, Jasmin Lalonde, Nikolaos Mellios, Alexander Hafez, Begum Alural, Jonathan L. Brigman, Nora I. Perrone-Bizzozero, Brigham J. Hartley, Praveen Chander, Evelyn Lozano, Kristen J. Brennand, Amber Zimmerman, Stephen J. Haggarty, Maree J. Webster, Roy H. Perlis, Stephen K. Amoah
Publikováno v:
Molecular Psychiatry
Although circular RNAs (circRNAs) are enriched in the mammalian brain, very little is known about their potential involvement in brain function and psychiatric disease. Here, we show that circHomer1a, a neuronal-enriched circRNA abundantly expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86030582e56d72d3704683a08389dd65
https://doi.org/10.1038/s41380-020-0653-4
https://doi.org/10.1038/s41380-020-0653-4
Autor:
Zhongwei Wang, Gregory Lallos, Jacob Brammer, Matthew Zimmer, Sarita Hedaya, Daniel Paull, Brodie Fischbacher, Brigham J. Hartley, Dillion Hutson
Monoclonalization refers to the isolation and expansion of a single cell derived from a cultured population. This is a valuable step in cell culture that serves to minimize a cell line’s technical variability downstream of cell-altering events, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493d461be3db175ffe3eb1fd277ffbf1
https://doi.org/10.1101/2020.12.28.424610
https://doi.org/10.1101/2020.12.28.424610
