Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brigham H. Mecham"'
Autor:
Kimberly A. Burton, Elisabeth Mahen, Eric Quentin Konnick, Sibel Blau, Michael O. Dorschner, Arturo B. Ramirez, Stephen C. Schmechel, Chaozhong Song, Rahul Parulkar, Stephanie Parker, Francis Mark Senecal, Colin C. Pritchard, Brigham H. Mecham, Christopher Szeto, Patricia Spilman, Jingchun Zhu, Vijayakrishna K. Gadi, Roy Ronen, Jackie Stilwell, Eric Kaldjian, Janusz Dutkowski, Stephen Charles Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, C. Anthony Blau
Publikováno v:
JCO Precision Oncology.
PURPOSE Patients with metastatic triple-negative breast cancer (mTNBC) have poor outcomes. The Intensive Trial of Omics in Cancer (ITOMIC) sought to determine the feasibility and potential efficacy of informing treatment decisions through multiple bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143431466f537651c2ca6a73977557ae
https://doi.org/10.1200/po.21.00280
https://doi.org/10.1200/po.21.00280
Autor:
Erhan Bilal, Janusz Dutkowski, Justin Guinney, In Sock Jang, Benjamin A Logsdon, Gaurav Pandey, Benjamin A Sauerwine, Yishai Shimoni, Hans Kristian Moen Vollan, Brigham H Mecham, Oscar M Rueda, Jorg Tost, Christina Curtis, Mariano J Alvarez, Vessela N Kristensen, Samuel Aparicio, Anne-Lise Børresen-Dale, Carlos Caldas, Andrea Califano, Stephen H Friend, Trey Ideker, Eric E Schadt, Gustavo A Stolovitzky, Adam A Margolin
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003047 (2013)
Breast cancer is the most common malignancy in women and is responsible for hundreds of thousands of deaths annually. As with most cancers, it is a heterogeneous disease and different breast cancer subtypes are treated differently. Understanding the
Externí odkaz:
https://doaj.org/article/99861dbc72c64dee91e8655ddfaa2222
Autor:
Timon Seeger, Alex C.Y. Chang, Isaac Perea-Gil, Mohamed Ameen, Thomas J. LaRocca, Brigham H. Mecham, Evgenios Neofytou, Gaurav Pandey, Ioannis Karakikes, Maricela Prado, Joseph C. Wu
Publikováno v:
Circ Heart Fail
Background: MicroRNAs are small, noncoding RNAs that play a key role in gene expression. Accumulating evidence suggests that aberrant microRNA expression contributes to the heart failure (HF) phenotype; however, the underlying molecular mechanisms ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b7e89082fd3b680fa967b51dc7cd7e
https://doi.org/10.1161/circheartfailure.119.006298
https://doi.org/10.1161/circheartfailure.119.006298
Autor:
Solene M. Evrard, Lahouaria Hadri, Valentin Fuster, Gwendalyn J. Randolph, Manfred Boehm, Brigham H. Mecham, Pedro R. Moreno, Pauline Rimmele, Elizabeth G. Nabel, Jason C. Kovacic, Ariella Cohain, Kenji Fujitani, Aya Nomura-Kitabayashi, Katherine C. Michelis, Gaurav Pandey, Roger J. Hajjar, K-Raman Purushothaman, Ludovic Benard, Jennifer Li, Valentina d'Escamard, Laura Lecce
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d91d1abf700046a18a95ee162b257fa
https://doaj.org/article/a0cca03eebdd4de2a5b3919ef6865a76
https://doaj.org/article/a0cca03eebdd4de2a5b3919ef6865a76
Autor:
Michael L. Cunningham, Federico M. Farin, Theodor K. Bammler, Negar Homayounfar, Zahra Afsharinejad, James W. MacDonald, Sarah S. Park, Brigham H. Mecham
Publikováno v:
Archives of Oral Biology. 60:1450-1460
Previous investigations suggest that the embryonic origins of the calvarial tissues (neural crest or mesoderm) may account for the molecular mechanisms underlying sutural development. The aim of this study was to evaluate the differences in the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f61dd1a7e95f54d6a2766bd5ac7b0e
https://doi.org/10.1016/j.archoralbio.2015.06.008
https://doi.org/10.1016/j.archoralbio.2015.06.008
Autor:
C. Anthony Blau, Carol Collins, Wayne Monsky, Nathan D. Price, William Stafford Noble, Michael O. Dorschner, Linda Dhaene, Brigham H. Mecham, Arturo Ramirez, Aime Radenbaugh, Jackie L. Stilwell, Chaozhong Song, Nicole M. Kuderer, Julie R. Gralow, Elisabeth Mahen, Colin C. Pritchard, Carla Grandori, David Haussler, Jeannine S. McCune, Mary Goldman, Frank Senecal, Kimberly A. Burton, Vijayakrishna K. Gadi, Jennifer M. Specht, Eric Kladjian, Sibel Blau, Jingchun Zhu
Publikováno v:
Cancer Research. 75:P4-08
We hypothesize that new insights into how cancers progress and respond to treatment will come from clinical trials that i) extensively characterize the molecular features of a patient’s cancer; ii) use results to predict drug susceptibilities; iii)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca946ce658e35b4bcd437272f609ef9
https://doi.org/10.1158/1538-7445.sabcs14-p4-08-01
https://doi.org/10.1158/1538-7445.sabcs14-p4-08-01
Autor:
Jennifer Li, Valentin Fuster, Lahouaria Hadri, Solene M. Evrard, Brigham H. Mecham, Pauline Rimmele, Jason C. Kovacic, Katherine C. Michelis, Roger J. Hajjar, Gaurav Pandey, Elizabeth G. Nabel, Valentina d'Escamard, Aya Nomura-Kitabayashi, Laura Lecce, Pedro Moreno, K-Raman Purushothaman, Kenji Fujitani, Gwendalyn J. Randolph, Ludovic Benard, Manfred Boehm, Ariella Cohain
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications
Nature Communications
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f332849d70e44f471b8db86788d4ed
https://doi.org/10.1038/ncomms14710
https://doi.org/10.1038/ncomms14710
Autor:
Joyoti Dey, Kyle Pedro, Derek Thirstrup, Adrian M. Dubuc, Michael LeBlanc, Paul A. Northcott, Michael D. Taylor, Stephen J. Tapscott, Xiaochong Wu, James M. Olson, David Shih, Brigham H Mecham
Publikováno v:
Cancer Research. 73:6828-6837
While medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a putative medu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7baafe7f106c69e2a89ce0474cc737
https://doi.org/10.1158/0008-5472.can-13-0730-t
https://doi.org/10.1158/0008-5472.can-13-0730-t
Autor:
Michael O. Dorschner, Kimberly A. Burton, Eric P. Kaldjian, Roy Ronen, Elizabeth Chang, Brent L. Wood, C. Anthony Blau, Sibel Blau, Sharon Austin, Francis M. Senecal, Stephen C. Schmechel, Colin C. Pritchard, Katy Dougherty, Rodney A. Schmidt, Jackie L. Stilwell, Anup Madan, Amie Radenbaugh, Michael L. Linenberger, Chaozhong Song, James Annis, Kellie Howard, Chris P. Miller, Jonathan R. Fromm, Brigham H. Mecham, Arturo Ramirez, Anju Thomas, Shelly Heimfeld, Elisabeth Mahen, David Haussler, Pamela S. Becker, Timothy J. Martins, Vitalina M. Komashko, Su-In Lee, Janusz Dutkowski, Jingchun Zhu
Publikováno v:
Scopus-Elsevier
Journal of the National Comprehensive Cancer Network : JNCCN, vol 14, iss 1
Journal of the National Comprehensive Cancer Network : JNCCN, vol 14, iss 1
Accelerating cancer research is expected to require new types of clinical trials. This report describes the Intensive Trial of OMics in Cancer (ITOMIC) and a participant with triple-negative breast cancer metastatic to bone, who had markedly elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a350a1c302eec57e7e7382b0276b19
https://pubmed.ncbi.nlm.nih.gov/26733551
https://pubmed.ncbi.nlm.nih.gov/26733551
Publikováno v:
Bioinformatics
Motivation: A major challenge in utilizing microarray technologies to measure nucleic acid abundances is ‘normalization’, the goal of which is to separate biologically meaningful signal from other confounding sources of signal, often due to unavo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0028c86a4d312a896cd02769659fe9
https://doi.org/10.1093/bioinformatics/btq118
https://doi.org/10.1093/bioinformatics/btq118