Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brigette C. Duckworth"'
Autor:
Amania A. Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C. Duckworth, Nicholas D. Huntington, James J. Moon, Marc Pellegrini, Stephen L. Nutt, Gabrielle T. Belz, Kim L. Good-Jacobson, Joanna R. Groom
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1758-1772.e4 (2019)
Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet. S
Externí odkaz:
https://doaj.org/article/cd5c2f99504b4133b0cdd744e3118bd0
Publikováno v:
Immunological reviewsREFERENCES. 306(1)
The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign pathogens, and cancer immunosurveillance. Within this complex structure, intranodal migration is vital for CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2c01f588d288a54f4fce3b129149de5
https://pubmed.ncbi.nlm.nih.gov/34882817
https://pubmed.ncbi.nlm.nih.gov/34882817
Autor:
Matthew A. Firth, Hai-Hui Xue, Laura K. Mackay, Tracy L Putoczki, Dinesh Raghu, Philip D. Hodgkin, Yang Liao, Qiutong Huang, Simone L Park, Brigette C. Duckworth, Ashley E. Franks, Dale I. Godfrey, Lisa A. Mielke, Melissa J. Davis, Michael Chopin, Soroor Hediyeh-Zadeh, Katherine Kedzierska, Vanessa L. Bryant, Gabrielle T. Belz, Wei Shi, Francisca F. Almeida, Jarny Choi, Ella Bridie Clemens, Carolyn A. Bell, Hui-Fern Koay
Publikováno v:
The Journal of Experimental Medicine
Mielke et al. show that TCF-1 limits IL-17–producing CD8+ T (Tc17) cell development from double-positive thymocytes through the sequential suppression of MAF and RORγt, while cementing conventional CD8+ T cell fate.
Interleukin (IL)-17–prod
Interleukin (IL)-17–prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96e17fb85c4cee737314c511398a22b
https://doi.org/10.1084/jem.20181778
https://doi.org/10.1084/jem.20181778
Autor:
Joanna R Groom, Brigette C. Duckworth
Publikováno v:
Immunological Reviews
The relationship between the extrinsic environment and the internal transcriptional network is circular. Naive T cells first engage with antigen‐presenting cells to set transcriptional differentiation networks in motion. In turn, this regulates spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1e0c162fcd4a4a5f928d052a713022
https://pubmed.ncbi.nlm.nih.gov/33586207
https://pubmed.ncbi.nlm.nih.gov/33586207
Autor:
Sofia Golenkina, Ronnie Blazev, Louise Y. Cheng, Michael Zavortink, Verena Wimmer, Benjamin L. Parker, Daniel Bakopoulos, Elizabeth L. Christie, William Lodge, Callum Dark, Shane Cheung, Brigette C. Duckworth, Francesca Froldi, Helena E. Richardson
Publikováno v:
Developmental cell. 56(18)
Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related mortalities. We have established a Drosophila larval model of organ wasting whereby epithelial overgrowth in eye-antennal dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f5161f8514e567f1f8977d793b182f
https://pubmed.ncbi.nlm.nih.gov/34473940
https://pubmed.ncbi.nlm.nih.gov/34473940
Autor:
Brigette C, Duckworth, Fanny, Lafouresse, Verena C, Wimmer, Benjamin J, Broomfield, Lennard, Dalit, Yannick O, Alexandre, Amania A, Sheikh, Raymond Z, Qin, Carolina, Alvarado, Lisa A, Mielke, Marc, Pellegrini, Scott N, Mueller, Thomas, Boudier, Kelly L, Rogers, Joanna R, Groom
Publikováno v:
Nature immunology. 22(4)
T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6fbf63783f022cdd1cf78469a149dee
https://pubmed.ncbi.nlm.nih.gov/33758404
https://pubmed.ncbi.nlm.nih.gov/33758404
Autor:
Brigette C. Duckworth, Verena C. Wimmer, Masaru Kanekiyo, Hannah G. Kelly, Frank Caruso, Stephen J. Kent, Jennifer A Juno, Hyon-Xhi Tan, Wenbo Jiang, Robyn Esterbauer, Adam K. Wheatley, Joanna R Groom, Yi Ju
Publikováno v:
JCI Insight
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mechanisms underpinning this effect remain poorly defined. Here, we investigated the immunogenicity of a prototypic ferritin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc387c870a602ece62ad2f8a4017490
https://pubmed.ncbi.nlm.nih.gov/32434990
https://pubmed.ncbi.nlm.nih.gov/32434990