Výsledky vyhledávání - "Brigadirova, A. A."

Akademický článek

DF-5 COMPOUND DELAYS DEVELOPMENT OF DIABETIC NEPHROPATHY IN RATS

Autor: A. A. Spasov, O. N. Zhukovskaya, A. I. Rashchenko, A. A. Brigadirova, R. A. Litvinov, N. A. Gurova, A. V. Smirnov, N. G. Pan’shin, H. S.A. Abbas, A. S. Morkovnik

Publikováno v: Фармация и фармакология (Пятигорск), Vol 10, Iss 6, Pp 549-561 (2023)

Advanced glycation end-products play an important role in the development of diabetic complications, so slowing down of glycated proteins’ cross-links formation have been suggested as a potential therapeutic option for the treatment of vascular dia

Externí odkaz: https://doaj.org/article/d4d13d12ef394ea1a10e466236f08455

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Akademický článek

Search for compounds with antioxidant and antiradical activity among N9-substituted 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles

Autor: Alexander A. Spasov, Anastasia A. Brigadirova, Olga N. Zhukovskaya, Anatoly S. Morkovnik, Yuliya V. Lifanova

Publikováno v: Research Results in Pharmacology, Vol 8, Iss 3, Pp 41-48 (2022)

Introduction: Biphenyl and imidazobenzimidazole derivatives attract ongoing attention as a combination of these two privileged substructures with promising pharmacological activities. The aim of this study was to synthesize and investigate in vitro a

Externí odkaz: https://doaj.org/article/5aaf0b3b253b4dbaac1834e3abc04a20

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Akademický článek

Searching for novel antagonists of adenosine A1 receptors among azolo[1,5-a]pyrimidine nitro derivatives

Autor: Dmitry S. Yakovlev, Pavel M. Vassiliev, Yana V. Agatsarskaya, Anastasia A. Brigadirova, Kira T. Sultanova, Maria O. Skripka, Alexander A. Spasov, Konstantin V. Savateev, Vladimir L. Rusinov, Dmitriy V. Maltsev

Publikováno v: Research Results in Pharmacology, Vol 8, Iss 2, Pp 69-75 (2022)

Introduction: Ligands of adenosine A1Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart f

Externí odkaz: https://doaj.org/article/7924b960ea9043d3a35444ae2f8b4398

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Akademický článek

Search for compounds with antioxidant and antiradical activity among N9-substituted 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles.

Autor: Spasov, Alexander A.¹ aspasov@mail.ru, Brigadirova, Anastasia A.¹ a.brigadirova@gmail.com, Zhukovskaya, Olga N.² zhukowskaia.ol@yandex.ru, Morkovnik, Anatoly S.² asmork@mail.ru, Lifanova, Yuliya V.¹ j_semenova_pharm@mail.ru

Publikováno v: Research Results in Pharmacology. 2022, Vol. 8 Issue 3, p41-48. 8p.

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The Effects of Nitroazolopyrimidines on the A1 Adenosine Receptor and Intraocular Pressure in Rats

Autor: K. V. Savateev, V. L. Rusinov, S. K. Kotovskaya, A. A. Spasov, L. V. Naumenko, A. S. Taran, A. A. Brigadirova, D. S. Yakovlev, K. T. Sultanova, N. M. Shcherbakova

Publikováno v: Russian Journal of Bioorganic Chemistry. 48:777-782

Abstract Six compounds of the 5(7)-alkylamino-6-nitroazolopyrimidine and 8-alkylazolo[5,1-b]purine series were selected based on the structural analysis of A1 adenosine receptor inhibitors and the role of this biological target in the modulation of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55f29fa1a7166a2130548f971eaaa375
https://doi.org/10.1134/s1068162022040185

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Akademický článek

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Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity

Autor: Denis A. Babkov, Olga N. Zhukovskaya, Anastasia A. Brigadirova, Diana R. Prilepskaya, Alexandra A. Kolodina, Abbas Haider S. Abbas, Anatolii S. Morkovnik, M. Elizabeth Sobhia, Ketan Ghosh, Alexander A. Spasov

Publikováno v: Chemical biologydrug design.

This work describes the synthesis of series hydrobromides of N-(4-biphenyl)methyl-N'-dialkylaminoethyl-2-iminobenzimidazoles, which, due to the presence of two privileged structural fragments (benzimidazole and biphenyl moieties), can be considered a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20edbf84b6adf17086f2bf3229660ace
https://pubmed.ncbi.nlm.nih.gov/36546307

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2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus

Autor: Alexander A. Spasov, Anatolii S. Morkovnik, V. A. Babkova, R. A. Litvinov, E.V. Sokolova, A. A. Brigadirova, Denis A. Babkov, O. N. Zhukovskaya

Publikováno v: Russian Chemical Bulletin. 69:774-780

New 2-amino- and 2-hydroxymethylbenzimidazoles were synthesized and used to prepare the previously unknown 1,2,3-tri- and 1,2,3,5-tetrasubstituted benzimidazolium bromides with a biphenyl-containing substituent at the imidazole nitrogen atom. In some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d421698d5acf4bb73ead607a1c2913ea
https://doi.org/10.1007/s11172-020-2832-5

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New data of topographic anatomy of semilunar line (semilunar line by A. Spiegel)

Autor: A. V. Chernykh, M. P. Popova, V. Yu. Brigadirova

Publikováno v: Medical alphabet. :70-72

Background. Today, a special place in surgical practice is the treatment of patients with spigelian hernias, which can be subcutaneous, interstitial, prepperitoneal, and make up 1% of all external hernias of the abdomen. The difficulty in diagnosing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60efe65357f8969a687bb8b56bacd312
https://doi.org/10.33667/2078-5631-2020-36-70-72

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