A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.

Autor: Li R; CAMS Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Colombo M; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Human Technopole, 20157 Milan, Italy., Wang G; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; MRC WIMM Centre for Computational Biology, University of Oxford, Oxford OX3 9DS, UK.; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China.; Qizhi Institute, 200232 Shanghai, China., Rodriguez-Romera A; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Benlabiod C; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Jooss NJ; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., O'Sullivan J; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Brierley CK; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Clark SA; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Pérez Sáez JM; Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1420 Buenos Aires, Argentina., Fernández PA; Department of Biotechnology and Biomedicine, Technical University of Denmark Kongens Lyngby 2800, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark Kongens Lyngby 2800, Denmark., Porse B; Finsen Laboratory, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen Denmark.; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark., Meng Y; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Khan AO; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Wen S; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Dong P; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China., Zhou W; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Centre for Evolutionary Biology, Fudan, Fudan University, 200438 Shanghai, China., Sousos N; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Murphy L; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Clarke M; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Olijnik AA; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Wong ZC; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Karali CS; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Sirinukunwattana K; Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK., Ryou H; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Norfo R; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Interdepartmental Centre for Stem Cells and Regenerative Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy., Cheng Q; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK., Ren Z; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Wuxi School of Medicine, Jiangnan University, Jiangsu 214122, China., Thongjuea S; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK., Rathinam VA; Department of Immunology, University of Connecticut Health School of Medicine, Farmington, CT 06030, USA., Krishnan A; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Rutgers Cancer Institute of New Jersey and Department of Biomedical Engineering, Rutgers University, New Brunswick, NJ 08901, USA., Royston D; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK., Rabinovich GA; Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1420 Buenos Aires, Argentina.; Facultad de Ciencias Exactas, Físicas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina., Mead AJ; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK., Psaila B; Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Hematology Theme, University of Oxford, Oxford OX3 9DS, UK.; Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK.; Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Oct 09; Vol. 16 (768), pp. eadj7552. Date of Electronic Publication: 2024 Oct 09.

Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes.

Autor: Brierley CK; Weatherall Institute of Molecular Medicine, Oxford, United Kingdom., Zabor EC; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio., Komrokji RS; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., DeZern AE; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland., Roboz GJ; Weill Cornell Medical College, New York, New York., Brunner AM; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Stone RM; Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Sekeres MA; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio., Steensma DP; Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

Publikováno v: Cancer [Cancer] 2020 Nov 01; Vol. 126 (21), pp. 4735-4743. Date of Electronic Publication: 2020 Aug 07.

Sugar thieves and addicts: nutrient subversion in JAK2 MPNs.

Autor: Brierley CK, Psaila B

Publikováno v: Blood [Blood] 2019 Nov 21; Vol. 134 (21), pp. 1778-1780.

Impact of graft-versus-lymphoma effect on outcomes after reduced intensity conditioned-alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies.

Autor: Brierley CK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Jones FM; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Hanlon K; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Peniket AJ; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Hatton C; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Collins GP; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Schuh A; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Medd P; Department of Haematology, Plymouth Hospitals NHS Trust, Plymouth, UK., Clark A; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Ward J; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Chaganti S; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Malladi R; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Parker A; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Craddock C; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Danby R; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Rocha V; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Serviço de Hematologia, Hemoterapia e Terapia Celular, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Publikováno v: British journal of haematology [Br J Haematol] 2019 Feb; Vol. 184 (4), pp. 547-557. Date of Electronic Publication: 2018 Nov 22.

Autologous Haematopoietic Stem Cell Transplantation for Crohn's Disease: A Retrospective Survey of Long-term Outcomes From the European Society for Blood and Marrow Transplantation.

Autor: Brierley CK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK., Castilla-Llorente C; Unité de transplantation des cellules souches, Département d'Hématologie Gustave Roussy, Villejuif, France., Labopin M; EBMT Paris Study Office, Department of Haematology, Université Pierre et Marie Curie, Saint Antoine Hospital, Paris, France., Badoglio M; EBMT Paris Study Office, Department of Haematology, Université Pierre et Marie Curie, Saint Antoine Hospital, Paris, France., Rovira M; BMT Unit, Haematology Department, Hospital Clínic of Barcelona, IDIBAPS, Institut Josep Carreras, Barcelona, Spain., Ricart E; Gastroenterology Department, Hospital Clínic of Barcelona, CIBER-EHD, IDIBAPS, Barcelona, Spain., Dierickx D; Department of Haematology, University Hospitals Leuven, Leuven, Belgium., Vermeire S; Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium., Hasselblatt P; Department of Medicine II, Medical Faculty and University Hospital Freiburg, Freiburg, Germany., Finke J; Department of Hematology, Oncology and Stem Cell Transplantation, Medical Faculty and University Hospital Freiburg, Freiburg, Germany., Onida F; Haematology - BMT Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy., Cassinotti A; Gastroenterology Unit, ASST Fatebenefatelli Sacco, Milan, Italy., Satsangi J; Gastro-intestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK., Kazmi M; Department of Haematology, Guy's and St Thomas' NHS Foundation Trust and King's College Hospital, London, UK., López-Sanromán A; Gastroenterology and Hepatology Department, Ramon y Cajal Hospital, Madrid, Spain., Schmidt C; Department of Gastroenterology, Medizinische Klinik II, Klinikum Fulda AG, Universitätsmedizin Marburg-Campus, Fulda, Germany., Farge D; Internal Medicine, Autoimmune and Vascular Diseases Unit, UF 04, AP-HP Hôpital Saint-Louis, Centre de Référence des Maladies auto-immunes systémiques Rares d'Ile-de-France [site constitutif], Filière FAI2R Paris 7 University, France., Travis SPL; Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, UK., Hawkey CJ; Nottingham Digestive Diseases Centre, School of Clinical Sciences, Queen's Medical Centre, Nottingham, UK., Snowden JA; Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Publikováno v: Journal of Crohn's & colitis [J Crohns Colitis] 2018 Aug 29; Vol. 12 (9), pp. 1097-1103.