Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.

Autor: Sala AJ; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, Gifsur-Yvette, France., Grant RA; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Imran G; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA., Morton C; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA., Brielmann RM; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA., Bott LC; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA., Watts J; School of Molecular Biosciences, Washington State University, Pullman WA, USA., Morimoto RI; Department of Molecular Biosciences, Northwestern University, Evanston IL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 25. Date of Electronic Publication: 2023 Apr 25.

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.

Autor: Labbadia J; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. Electronic address: j.labbadia@ucl.ac.uk., Brielmann RM; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA., Neto MF; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA., Lin YF; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Haynes CM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Morimoto RI; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA. Electronic address: r-morimoto@northwestern.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Nov 07; Vol. 21 (6), pp. 1481-1494.

A network approach to discerning the identities of C. elegans in a free moving population.

Autor: Winter PB; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Brielmann RM; Department of Molecular Biosciences, Rice Institute for Biomedical Sciences, Northwestern University, Evanston, IL, USA., Timkovich NP; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Navarro HT; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Teixeira-Castro A; Department of Molecular Biosciences, Rice Institute for Biomedical Sciences, Northwestern University, Evanston, IL, USA.; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Morimoto RI; Department of Molecular Biosciences, Rice Institute for Biomedical Sciences, Northwestern University, Evanston, IL, USA., Amaral LA; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Department of Physics and Astronomy, Northwestern University, Evanston, IL, USA.; Northwestern Institute on Complex Systems and Data Science, Northwestern University, Evanston, IL, USA.; Howard Hughes Medical Institute, Northwestern University, Evanston, IL, USA.

Publikováno v: Scientific reports [Sci Rep] 2016 Oct 11; Vol. 6, pp. 34859. Date of Electronic Publication: 2016 Oct 11.

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

Autor: Teixeira-Castro A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 4 Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA., Jalles A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal pmaciel@ecsaude.uminho.pt., Esteves S; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal pmaciel@ecsaude.uminho.pt., Kang S; 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 5 Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA 6 Chemistry of Life Processes Institute and Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, USA., da Silva Santos L; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Silva-Fernandes A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Neto MF; 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 4 Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA., Brielmann RM; 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 4 Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA., Bessa C; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Duarte-Silva S; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Miranda A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Oliveira S; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Neves-Carvalho A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Bessa J; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Summavielle T; 7 IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal., Silverman RB; 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 5 Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA 6 Chemistry of Life Processes Institute and Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, USA., Oliveira P; 8 ICBAS-Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal., Morimoto RI; 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 4 Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA., Maciel P; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal pmaciel@ecsaude.uminho.pt.

Publikováno v: Brain : a journal of neurology [Brain] 2015 Nov; Vol. 138 (Pt 11), pp. 3221-37. Date of Electronic Publication: 2015 Sep 15.