Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype.

Autor: Prashant Sharma, Marie Reichert, Yan Lu, Thomas C Markello, David R Adams, Peter J Steinbach, Brie K Fuqua, Xenia Parisi, Stephen G Kaler, Christopher D Vulpe, Gregory J Anderson, William A Gahl, May Christine V Malicdan

Publikováno v: PLoS Genetics, Vol 15, Iss 5, p e1008143 (2019)

Maintenance of the correct redox status of iron is functionally important for critical biological processes. Multicopper ferroxidases play an important role in oxidizing ferrous iron, released from the cells, into ferric iron, which is subsequently d

Externí odkaz: https://doaj.org/article/8434e917264b45e197052e868151132b

Sex-specific metabolic functions of adipose Lipocalin-2

Autor: Karthickeyan Chella Krishnan, Simon Sabir, Michaël Shum, Yonghong Meng, Rebeca Acín-Pérez, Jennifer M. Lang, Raquel R. Floyd, Laurent Vergnes, Marcus M. Seldin, Brie K. Fuqua, Dulshan W. Jayasekera, Sereena K. Nand, Diana C. Anum, Calvin Pan, Linsey Stiles, Miklós Péterfy, Karen Reue, Marc Liesa, Aldons J. Lusis

Publikováno v: Molecular Metabolism, Vol 30, Iss , Pp 30-47 (2019)

Objective: Lipocalin-2 (LCN2) is a secreted protein involved in innate immunity and has also been associated with several cardiometabolic traits in both mouse and human studies. However, the causal relationship of LCN2 to these traits is unclear, and

Externí odkaz: https://doaj.org/article/a839a782c02a421289dfd3caac2fec75

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux

Autor: Min Chen, Jiashuo Zheng, Guohao Liu, En Xu, Junzhuo Wang, Brie K. Fuqua, Chris D. Vulpe, Gregory J. Anderson, Huijun Chen

Publikováno v: Redox Biology, Vol 17, Iss , Pp 432-439 (2018)

Little is known about the iron efflux from the pancreas, but it is likely that multicopper ferroxidases (MCFs) are involved in this process. We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice and Heph/Cp double-knockout mice t

Externí odkaz: https://doaj.org/article/34a476480a7849a7adb7826b8c552dd7

The biology of mammalian multi-copper ferroxidases

Autor: Sheridan L. Helman, Jie Zhou, Brie K. Fuqua, Yan Lu, James F. Collins, Huijun Chen, Christopher D. Vulpe, Gregory J. Anderson, David M. Frazer

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, vol 36, iss 2
Biometals

The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis. Each of these enzymes contains six biosynthetically incorporate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b61329225401e190bc038d5c2214ce
https://escholarship.org/uc/item/35n736xd

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in MiceSummary

Autor: Mete Civelek, Judith Knehr, Samuel W. French, Brie K. Fuqua, Simon T. Hui, Chinweike Ukomadu, Calvin Pan, Kevin Wroblewski, Margarete Mehrabian, Rita M. Cantor, Ashot Asaryan, Joseph Loureiro, Sara G. Haroutunian, Jason Borawski, Brian W. Parks, Aldons J. Lusis, Walter Carbone, Clara E. Magyar, Nicole A. Renaud, Simon W. Beaven, Kara Clerkin, Iina Tuominen, Guglielmo Roma

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 199-220 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 1
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536618b237e4093c54e4e8a03f67626f
http://www.sciencedirect.com/science/article/pii/S2352345X2030134X