Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Bridgette M. Cumming"'
Autor:
Wei Zhou, Shaojia Huang, Bridgette M. Cumming, Yong Zhang, Wei Tang, Adrie J. C. Steyn, Shiyun Chen, Yangbo Hu
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Cell division must be coordinated with DNA repair, which is strictly regulated in response to different drugs and environmental stresses in bacteria. However, the mechanisms by which mycobacteria orchestrate these two processes remain largel
Externí odkaz:
https://doaj.org/article/66df5b8440294bcca0ee81ff742e1610
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection. Recent studies have therefore focused on identifying hos
Externí odkaz:
https://doaj.org/article/761cacf341784afaac3f570449cb15f6
Autor:
Dirk A. Lamprecht, Peter M. Finin, Md. Aejazur Rahman, Bridgette M. Cumming, Shannon L. Russell, Surendranadha R. Jonnala, John H. Adamson, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tube
Externí odkaz:
https://doaj.org/article/9a86dfe38a8246cd9d09bf2f836eeae4
Autor:
Zhenkang Chen, Yangbo Hu, Bridgette M. Cumming, Pei Lu, Lipeng Feng, Jiaoyu Deng, Adrie J.C. Steyn, Shiyun Chen
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2512-2524 (2016)
During the course of infection, Mycobacterium tuberculosis (Mtb) is exposed to diverse redox stresses that trigger metabolic and physiological changes. How these stressors are sensed and relayed to the Mtb transcriptional apparatus remains unclear. H
Externí odkaz:
https://doaj.org/article/455f9526773e416e81c3ea086dc806f3
Autor:
Vikram Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht, John H. Adamson, Vineel P. Reddy, Krishna C. Chinta, James H. Mazorodze, Joel N. Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 572-585 (2016)
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox bu
Externí odkaz:
https://doaj.org/article/e86030a4d9474eae8ff100fea63540c3
Publikováno v:
eLife, Vol 7 (2018)
How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb in
Externí odkaz:
https://doaj.org/article/f415673efe5547e9af0ff253c87da097
Autor:
Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006490 (2017)
[This corrects the article DOI: 10.1371/journal.ppat.1006389.].
Externí odkaz:
https://doaj.org/article/32330ee4275c4525aff1402a66f64a54
Autor:
Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006389 (2017)
Signals modulating the production of Mycobacterium tuberculosis (Mtb) virulence factors essential for establishing long-term persistent infection are unknown. The WhiB3 redox regulator is known to regulate the production of Mtb virulence factors, how
Externí odkaz:
https://doaj.org/article/bbe88887c055490abf4056eb3e684a74
Autor:
Miguel Fernández-García, Vineel P. Reddy, Serge Rudaz, Coral Barbas, Adrie J. C. Steyn, Fernanda Rey-Stolle, Antonia García, Julien Boccard, Bridgette M. Cumming
Publikováno v:
Journal of Proteome Research, Vol. 19, No 5 (2020) pp. 2053-2070
Journal of Proteome Research
Journal of Proteome Research
The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry platforms to track altered lung metabolic changes associated with Mtb infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f691ea7415f0703a03a7370edabf473a
https://doi.org/10.1021/acs.jproteome.9b00868
https://doi.org/10.1021/acs.jproteome.9b00868
Autor:
Rui Wang, Shannon L. Russell, Kievershen Nargan, Pratistadevi K. Ramdial, John H. Adamson, Adrie J. C. Steyn, Bridgette M. Cumming, Aejazur Rahman, Hayden T Pacl, Threnesan Naidoo, Kelvin W. Addicott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Tuberculosis (TB) is responsible for millions of deaths each year and several billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb modulates host factors, such as endogenous gaseous signalling molecules, to per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ffb8f73d63d5b203fcfa9931e8d7cb
https://doi.org/10.1073/pnas.1919211117
https://doi.org/10.1073/pnas.1919211117