Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Bridgette A, Barry"'
Autor:
R. Atlee Watson, Bridgette A. Barry, Adam R. Offenbacher, Raquel L. Lieberman, Mohammad S. Safiarian
Publikováno v:
The Journal of Physical Chemistry Letters. 12:9020-9025
Ribonucleotide reductase (RNR), which supplies the building blocks for DNA biosynthesis and its repair, has been linked to human diseases and is emerging as a therapeutic target. Here, we present a mechanistic investigation of triapine (3AP), a clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bc52674081eb04a7f5659dc9b624d59
https://doi.org/10.1021/acs.jpclett.1c02103
https://doi.org/10.1021/acs.jpclett.1c02103
Publikováno v:
The journal of physical chemistry. B. 125(30)
The enzyme, ribonucleotide reductase (RNR), is essential for DNA synthesis in all cells. The class Ia Escherichia coli RNR consists of two dimeric subunits, α2 and β2, which form an active but unstable heterodimer of dimers, α2β2. The structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938d684067de96804be31912c0b4c7a5
https://pubmed.ncbi.nlm.nih.gov/34289692
https://pubmed.ncbi.nlm.nih.gov/34289692
Autor:
San Hui Chi, James C. Gumbart, Miranda McDaniel, Zhanjun Guo, Hyea Hwang, Bridgette A. Barry, Tyler G. McCaslin, Cynthia V. Pagba, Joseph W. Perry, Cristina Olivieri, Gianluigi Veglia, Fernando Porcelli
Publikováno v:
The Journal of Physical Chemistry. B
Tyrosine–tryptophan (YW) dyads are ubiquitous structural motifs in enzymes and play roles in proton-coupled electron transfer (PCET) and, possibly, protection from oxidative stress. Here, we describe the function of YW dyads in de novo designed 18-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ec6a12aa95324c3bd96408b70c754a
https://doi.org/10.1021/acs.jpcb.8b12452
https://doi.org/10.1021/acs.jpcb.8b12452
Autor:
Tyler G. McCaslin, Joseph W. Perry, Bridgette A. Barry, James C. Gumbart, Cynthia V. Pagba, Hyea Hwang, San-Hui Chi
Publikováno v:
Chemical Communications. 55:9399-9402
Tyrosine residues act as intermediates in proton coupled electron transfer reactions (PCET) in proteins. For example, in ribonucleotide reductase (RNR), a tyrosyl radical oxidizes an active site cysteine via a 35 A pathway that contains multiple arom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6702d35c741e7f86959902391459bf1
https://doi.org/10.1039/c9cc04067f
https://doi.org/10.1039/c9cc04067f
Publikováno v:
The journal of physical chemistry. B. 124(2)
Proton-coupled electron transfer (PCET) is fundamental to many important biological reactions, including solar energy conversion and DNA synthesis. For example, class Ia ribonucleotide reductases (RNRs) contain a tyrosyl radical-diiron cofactor with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb85d786fce288c2061fef913d992e01
https://pubmed.ncbi.nlm.nih.gov/31904962
https://pubmed.ncbi.nlm.nih.gov/31904962
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42220 (2012)
Light stress in plants results in damage to the water oxidizing reaction center, photosystem II (PSII). Redox signaling, through oxidative modification of amino acid side chains, has been proposed to participate in this process, but the oxidative sig
Externí odkaz:
https://doaj.org/article/1299025b23a84e94a90a9dcfa26e0c79
Publikováno v:
ChemPhysChem. 19:1428-1431
As a noninvasive molecular analysis technique, ultraviolet resonance Raman (UVRR) spectroscopy represents a label-free method suitable for characterizing biomolecules. Using UVRR spectroscopy, we collected spectral fingerprints of UV absorbing cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c23ede1d4bd12aef739c494fafcd4c
https://doi.org/10.1002/cphc.201800252
https://doi.org/10.1002/cphc.201800252
Chloride Maintains a Protonated Internal Water Network in the Photosynthetic Oxygen Evolving Complex
Publikováno v:
The Journal of Physical Chemistry B. 121:10327-10337
In photosystem II (PSII), water oxidation occurs at a Mn4CaO5 cluster and results in production of molecular oxygen. The Mn4CaO5 cluster cycles among five oxidation states, called Sn states. As a result, protons are released at the metal cluster and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7a21c00638a1791188ae0d57df322f
https://doi.org/10.1021/acs.jpcb.7b08358
https://doi.org/10.1021/acs.jpcb.7b08358
Autor:
Bridgette A. Barry, Zhanjun Guo
Publikováno v:
The Journal of Physical Chemistry B. 121:3987-3996
A redox-active tyrosine, YZ (Y161 in the D1 polypeptide), is essential in photosystem II (PSII), which conducts photosynthetic oxygen evolution. On each step of the light-driven oxygen evolving reaction, YZ radical is formed by a chlorophyll cation r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5a7263e4a9ee181d115f7f5cca0e32
https://doi.org/10.1021/acs.jpcb.7b01802
https://doi.org/10.1021/acs.jpcb.7b01802
Autor:
Bridgette A. Barry, Tyler G. McCaslin, James C. Gumbart, Hyea Hwang, Cynthia V. Pagba, Christina M. Nevin, Anna Pavlova, Anthony Hazel
Publikováno v:
The Journal of Physical Chemistry B. 121:3536-3545
Tyrosine-based radical transfer plays an important role in photosynthesis, respiration, and DNA synthesis. Radical transfer can occur either by electron transfer (ET) or proton coupled electron transfer (PCET), depending on the pH. Reversible conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac573c772a97627d507d9a27b151c86f
https://doi.org/10.1021/acs.jpcb.6b09481
https://doi.org/10.1021/acs.jpcb.6b09481