Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bridgett Knox"'
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD).
Autor:
Lin Xu, Yanjie Zhao, Jing Chen, Lei Guo, Si Chen, Leihong Wu, Dianke Yu, Baitang Ning, Yuan Jin, William H. Tolleson, Weida Tong, Xubing Wang, Bridgett Knox, Jiao Luo, Dongying Li
Publikováno v:
Drug Metab Dispos
Recent studies have shown that microRNAs and long noncoding RNAs (lncRNAs) regulate the expression of drug metabolizing enzymes (DMEs) in human hepatic cells and that a set of DMEs, including UDP glucuronosyltransferase (UGT) 2B15, is down-regulated
Publikováno v:
Molecular Toxicology Protocols ISBN: 9781071602225
Methods Mol Biol
Methods Mol Biol
microRNAs (miRNAs) modulate the expression of enzymes responsible for activation or detoxification of xenobiotics and toxicants. miRNAs are dysregulated in response to environmental exposure and have been implicated in toxicological events. Many in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dac2f520c41c24cd4546b711da1136
https://doi.org/10.1007/978-1-0716-0223-2_30
https://doi.org/10.1007/978-1-0716-0223-2_30
Autor:
Dianke Yu, Leihong Wu, Dongying Li, Lei Guo, Si Chen, Baitang Ning, Bridgett Knox, Weida Tong, William H. Tolleson, Fang Liu
Publikováno v:
Arch Toxicol
Noncoding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate gene expression in many physiological and pathological processes, including drug metabolism. Drug metabolizing enzymes (DMEs) are critical components in drug-induc
Autor:
Kostiantyn Dreval, William B. Mattes, Yongli Guo, Linjuan Zeng, Yaqiong Jin, Weida Tong, Huixiao Hong, Sudeepa Bhattacharyya, Hong Fang, Bridgett Knox, Tieliu Shi, Leming Shi, Yong Wang, Wenming Xiao, Zhen Ren, Igor P. Pogribny, Leihong Wu, Volodymyr Tryndyak, Jinchun Sun, Si Chen, Baitang Ning, Pritmohinder S. Gill, Richard D. Beger, Yinting Chen, Xi Yang, William H. Tolleson, Sandra S. McCullough, Laura K. Schnackenberg, Lei Guo, Nan Mei, Dianke Yu, Laura P. James
Publikováno v:
Archives of Toxicology. 92:845-858
Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive
Autor:
Lei Guo, Tieliu Shi, Dianke Yu, Weida Tong, Li-Rong Yu, Bridgett Knox, Yuanfeng Wu, Si Chen, Linjuan Zeng, Yinting Chen, Kaihong Huang, Yong Wang, Jiwei Chen, Zhen Ren, Baitang Ning, David Liu
Publikováno v:
Biochemical Pharmacology. 140:139-149
Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20–25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination c
Autor:
Zhichao Liu, Lei Guo, Si Chen, Leihong Wu, Baitang Ning, Dongying Li, William H. Tolleson, Dianke Yu, Weida Tong, Bridgett Knox
Publikováno v:
Biochemical pharmacology. 169
Drug metabolizing enzymes mediate biotransformation of drugs and play an essential role in drug efficacy and toxicity. Human sulfotransferases are a superfamily of Phase II detoxification enzymes that metabolize a wide spectrum of endogenous compound
Autor:
Bridgett Knox, Baitang Ning, Zhen Ren, Yong Wang, Si Chen, Yaqiong Jin, William H. Tolleson, Helen Deng, Yongli Guo, Dianke Yu
Publikováno v:
Biochemical Pharmacology. 113:88-96
Cytochrome P450 2B6 (CYP2B6), mainly expressed in the liver and brain, is important for processing a number of widely used drugs. Variations in CYP2B6 expression are associated with decreased drug efficacy or adverse effects in some patients. Althoug
Autor:
Suzanne M. Morris, Vasily N. Dobrovolsky, Bridgett Knox, Javier R. Revollo, Dayton M. Petibone, Page B. McKinzie, Baitang Ning
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 795:60-69
Closely related TK6, WTK1, and NH32 human B-lymphoblastoid cell lines differ in their p53 functional status. These lines are used frequently in genotoxicity studies and in studies aimed at understanding the role of p53 in DNA repair. Despite their ro
Autor:
Bridgett Knox, Dongying Li, Leihong Wu, Lei Guo, Weida Tong, William H. Tolleson, Baitang Ning, Si Chen, Fang Liu
Publikováno v:
The FASEB Journal. 34:1-1