Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bridget T. Hughes"'
Autor:
Luke J. Drury, Brian M. Fissel, Bridget T. Hughes, Adam J. Dupuy, Jonathan E. Grim, Keith R. Loeb, Bruce E. Clurman, Aaron L. Sarver, Sue E. Knoblaugh, Nyka J. Osteen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Insertional mutagenesis is a powerful means of identifying cancer drivers in animal models. We used the Sleeping Beauty (SB) transposon/transposase system to identify activated oncogenes in hematologic cancers in wild-type mice and mice that express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fb0a71cb0b6a76666de9190a94566a
http://link.springer.com/article/10.1038/s41598-019-41805-x
http://link.springer.com/article/10.1038/s41598-019-41805-x
Prolyl hydroxylation functions in diverse cellular pathways, such as collagen biogenesis, oxygen sensing, and translation termination. Prolyl hydroxylation is catalyzed by 2-oxoglutarate (2-OG) oxygenases. The fission yeast 2-OG oxygenase Ofd1 dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579e9074835765cbee5f770be3f261e5
Publikováno v:
Molecular and Cellular Biology. 37
Cyclin E, in conjunction with its catalytic partner cyclin-dependent kinase 2 (CDK2), regulates cell cycle progression as cells exit quiescence and enter S-phase. Multiple mechanisms control cyclin E periodicity during the cell cycle, including phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b6a436a3319116dcabfdf65e5586e4
https://doi.org/10.1128/mcb.00657-16
https://doi.org/10.1128/mcb.00657-16
Publikováno v:
Proceedings of the National Academy of Sciences. 110:8954-8959
Cyclin-dependent kinases (Cdks) coordinate cell division, and their activities are tightly controlled. Phosphorylation of threonine 14 (T14) and tyrosine 15 (Y15) inhibits Cdks and regulates their activities in numerous physiologic contexts. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b32641f25cf5530407270a9859e9a7
https://doi.org/10.1073/pnas.1302927110
https://doi.org/10.1073/pnas.1302927110
Publikováno v:
Molecular Cell. 44(2):225-234
Regulation of gene expression plays an integral role in adaptation of cells to hypoxic stress. In mammals, prolyl hydroxylases control levels of the central transcription factor hypoxia inducible factor (HIF) through regulation of HIFα subunit stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5085e97c189e6d5f24a25ebffcb79a
Publikováno v:
Nucleic Acids Research
Eukaryotic cells respond to changes in environmental oxygen supply by increasing transcription and subsequent translation of gene products required for adaptation to low oxygen. In fission yeast, the ortholog of mammalian sterol regulatory element bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe79fffc462ba59c65970263d089b80
https://doi.org/10.1093/nar/gkn027
https://doi.org/10.1093/nar/gkn027
Publikováno v:
Molecular Cancer Research. 14:IA20-IA20
Cyclin-dependent kinase 2 (CDK2) coordinates diverse process, including cell cycle entry and progression, DNA replication, and DNA damage and replication stress responses. Cancers frequently contain mutations in genes that regulate CDK2, which is als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27f2597ba4831a400d590d1e1249e7a
https://doi.org/10.1158/1557-3125.cellcycle16-ia20
https://doi.org/10.1158/1557-3125.cellcycle16-ia20
Publikováno v:
The Journal of biological chemistry. 284(31)
Sre1, the fission yeast sterol regulatory element-binding protein (SREBP), is an endoplasmic reticulum (ER) membrane-bound transcription factor that is a principal regulator of hypoxic gene expression. Under low oxygen, Sre1 is cleaved from its inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5743d2433186079f6b155fb7e0f270bc
https://pubmed.ncbi.nlm.nih.gov/19520858
https://pubmed.ncbi.nlm.nih.gov/19520858
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af5288d005f2198ac74028a6899333d
https://doi.org/10.1096/fasebj.23.1_supplement.689.7
https://doi.org/10.1096/fasebj.23.1_supplement.689.7
Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast
Publikováno v:
The EMBO journal. 28(2)
Sre1, the fission yeast sterol regulatory element-binding protein, is an ER membrane-bound transcription factor that controls adaptation to low oxygen growth. Under low oxygen, Sre1 is proteolytically cleaved and the N-terminal transcription factor d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71590382dc0f1a0a6faaf39064aa0df
https://pubmed.ncbi.nlm.nih.gov/19158663
https://pubmed.ncbi.nlm.nih.gov/19158663