Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Bridget Sanford"'
Autor:
Faye M. Walker, Lays Martin Sobral, Etienne Danis, Bridget Sanford, Sahiti Donthula, Ilango Balakrishnan, Dong Wang, Angela Pierce, Sana D. Karam, Soudabeh Kargar, Natalie J. Serkova, Nicholas K. Foreman, Sujatha Venkataraman, Robin Dowell, Rajeev Vibhakar, Nathan A. Dahl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction in
Externí odkaz:
https://doaj.org/article/d56159185f7f4564adf980120f3ab2ba
Autor:
John DeSisto, John T. Lucas, Ke Xu, Andrew Donson, Tong Lin, Bridget Sanford, Gang Wu, Quynh T. Tran, Dale Hedges, Chih-Yang Hsu, Gregory T. Armstrong, Michael Arnold, Smita Bhatia, Patrick Flannery, Rakeb Lemma, Lakotah Hardie, Ulrich Schüller, Sujatha Venkataraman, Lindsey M. Hoffman, Kathleen Dorris, Jean M. Mulcahy Levy, Todd C. Hankinson, Michael Handler, Arthur K. Liu, Nicholas Foreman, Rajeev Vibhakar, Kenneth Jones, Sariah Allen, Jinghui Zhang, Suzanne J. Baker, Thomas E. Merchant, Brent A. Orr, Adam L. Green
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in
Externí odkaz:
https://doaj.org/article/83b97f7c6e28476688641217970f4a3f
Autor:
Diana Jalal, Bridget Sanford, Brandon Renner, Patrick Ten Eyck, Jennifer Laskowski, James Cooper, Mingyao Sun, Yousef Zakharia, Douglas Spitz, Ayotunde Dokun, Massimo Attanasio, Kenneth Jones, Joshua M. Thurman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cardiovascular disease (CVD) is the most common cause of death in patients with native and post-transplant chronic kidney disease (CKD). To identify new biomarkers of vascular injury and inflammation, we analyzed the proteome of plasma and c
Externí odkaz:
https://doaj.org/article/76de923efa7f4196b52531ea0c40ccba
In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.
Autor:
Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Externí odkaz:
https://doaj.org/article/5560076a792640a2978e1586fa78271e
Autor:
Brian F Niemeyer, Bridget Sanford, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010019 (2021)
Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of late
Externí odkaz:
https://doaj.org/article/9de3c67c9b8e4b4dafad6081faeabaa1
Autor:
Ilango Balakrishnan, Etienne Danis, Angela Pierce, Krishna Madhavan, Dong Wang, Nathan Dahl, Bridget Sanford, Diane K. Birks, Nate Davidson, Dennis S. Metselaar, Michaël Hananja Meel, Rakeb Lemma, Andrew Donson, Trinka Vijmasi, Hiroaki Katagi, Ismail Sola, Susan Fosmire, Irina Alimova, Jenna Steiner, Ahmed Gilani, Esther Hulleman, Natalie J. Serkova, Rintaro Hashizume, Cynthia Hawkins, Angel M. Carcaboso, Nalin Gupta, Michelle Monje, Nada Jabado, Kenneth Jones, Nicholas Foreman, Adam Green, Rajeev Vibhakar, Sujatha Venkataraman
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108286- (2020)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tum
Externí odkaz:
https://doaj.org/article/df550ba18a7344fb83017de0c06084bc
Autor:
Austin E. Gillen, Kent A. Riemondy, Vladimir Amani, Andrea M. Griesinger, Ahmed Gilani, Sujatha Venkataraman, Krishna Madhavan, Eric Prince, Bridget Sanford, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Ken L. Jones, Siddhartha Mitra, Jay R. Hesselberth, Nicholas K. Foreman, Andrew M. Donson
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108023- (2020)
Summary: Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development
Externí odkaz:
https://doaj.org/article/86aaa43b961a406abbb08113d63ce8d6
Autor:
Andrew M Donson, Kelsey C Bertrand, Kent A Riemondy, Dexiang Gao, Yonghua Zhuang, Bridget Sanford, Gregory A Norris, Rebecca J Chapman, Rui Fu, Nicholas Willard, Andrea M Griesinger, Graziella Ribeiro de Sousa, Vladimir Amani, Enrique Grimaldo, Todd C Hankinson, Ffyona Booker, Martin Sill, Richard G Grundy, Kristian W Pajtler, David W Ellison, Nicholas K Foreman, Timothy A Ritzmann
Publikováno v:
Neuro-Oncology.
Background Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At relapse, it is typically incurable even with re-resection and re-irradiation. The biology of recurren
Autor:
Sujatha Venkataraman, Rajeev Vibhakar, Nathan A. Dahl, Siddhartha S. Mitra, Eva S. Nozik, Dong Wang, Faye Walker, Hanan B. Elajaili, Susan Fosmire, Bridget Sanford, Angela Pierce, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Krishna Madhavan
Purpose:Tumor relapse after radiotherapy is a major hurdle in treating pediatric H3K27M-mutant diffuse midline gliomas (DMG). Radiotherapy-induced stress increases association of BCL2 family of proteins with BH3 pro-apoptotic activators preventing ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01549208de2627e19cf8265c987587d0
https://doi.org/10.1158/1078-0432.c.6532404
https://doi.org/10.1158/1078-0432.c.6532404
Autor:
Sujatha Venkataraman, Rajeev Vibhakar, Nathan A. Dahl, Siddhartha S. Mitra, Eva S. Nozik, Dong Wang, Faye Walker, Hanan B. Elajaili, Susan Fosmire, Bridget Sanford, Angela Pierce, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Krishna Madhavan
Supplementary Figure from Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b74cbe64a664f43743bf41435b3914
https://doi.org/10.1158/1078-0432.22486851.v1
https://doi.org/10.1158/1078-0432.22486851.v1