Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Bridget P. Williams"'
Autor:
Hiroshi Hiasa, Delaney E Hart, Sarah R.C. Lentz, Tyrell R. Towle, Lisa M. Oppegard, Robert J. Kerns, Justine L. Delgado, Beverly Norris, Chaitanya A. Kulkarni, Craig M. Flory, Daryl J. Murry, Bridget P. Williams, Robert J. Schumacher
Publikováno v:
Investigational New Drugs. 37:378-383
Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that target eukaryotic type IIA topoisomerases. Fluoroquinolones bind and stabilize type IIA topoisomerase-DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b318fbf452cb83f75309803c081e217
https://doi.org/10.1007/s10637-018-0666-x
https://doi.org/10.1007/s10637-018-0666-x
Autor:
Hiroshi Hiasa, Chaitanya A. Kulkarni, Lisa M. Oppegard, Robert J. Kerns, Taylor A. Picha, Tyrell R. Towle, Bridget P. Williams
Structural studies of topoisomerase-fluoroquinolone-DNA ternary complexes revealed a cavity between the quinolone N-1 position and the active site tyrosine. Fluoroquinolone derivatives having positively charged or aromatic moieties extended from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af11b5cabef9f663cc4d013b08edfc20
https://europepmc.org/articles/PMC5938125/
https://europepmc.org/articles/PMC5938125/
