Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bridget M. Sutton"'
Autor:
John Nolan, E. Martin Fielden, Matthew A. Naylor, Peter O'Neill, Bridget M. Sutton, Gerald E. Adams, Ian J. Stratford
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 29:333-337
To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of10 in a range of murine and human tumor cells in vitro.Reduction of 1 has been initiated radiolytically and photochemically in aqueous
Autor:
Bridget M. Sutton, Ralph A. Richardson
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 581:277-280
A simple and sensitive gas chromatographic method has been developed for the determination of timolol in plasma using electron-capture detection and propranolol as internal standard. Timolol was extracted using butyl chloride and derivatized using tr
Autor:
J. C. M. Bremner, Nigel J. Reeves, Pauline J. Wood, Ian J. Stratford, Gerald E. Adams, Bridget M. Sutton, J. M. Sansom, Jill K. Bradley
Publikováno v:
International journal of radiation oncology, biology, physics. 29(3)
Purpose: To investigate whether application of "early" photodynamic therapy (PDT) using a disulphonated aluminium phthallocyanine photosensitizer can potentiate the action of melphalan in experimental RIF-1 tumors in vivo . Methods and Materials: Tum
Autor:
Bridget M. Sutton, Gerald E. Adams, Nigel J. Reeves, S. Cole, E. Martin Fielden, Matthew A. Naylor, Ian J. Stratford
Publikováno v:
International journal of radiation oncology, biology, physics. 29(2)
Purpose: 1,2-Dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2- a ] pyrido [3,2- e ] pyrazine-5-oxide (RB90740) is a bioreductive drug with an oxic to hypoxic toxicity ratio of 16 in cultured V79 cells in vitro . The aim of this study was to exami
Autor:
Bridget M. Sutton, Duncan J. McLennan, William A. Denny, William R. Wilson, Charmian J. O'Connor
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :951
The cytotoxicity of many nitroaromatic compounds is mediated by bioreduction. There is a correlation between the one-electron-reduction potentials and cytotoxic potencies of simple nitroheterocycles such as nitroimidazoles, but no such correlation is
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1637
Studies of the hydrolysis of the hypoxia-selective cytotoxic agent 9-[3-(N,N-dimethylamino)-propylamino]-1-nitroacridine (nitracrine) and several of its 4-substituted analogues and nitro-positional isomers have been carried out. Examination of the ef
Publikováno v:
Advances in Colloid and Interface Science. 28:1-34
The effects of proteins, both endogenous and exogenous, on the activity of lipases against water soluble and water insoluble substrates have been reviewed. The enzymes considered are pancreatic and gastric lipases, and lipoprotein, bile-salt-stimulat
Publikováno v:
Journal of Bioactive and Compatible Polymers. 3:390-402
The initial rates of hydrolysis of triolein, catalyzed by bile-salt-stimulated hu man milk lipase, BSSL, were measured at pH 7.5 and 37 ° C, in the presence of selected proteins, namely immunoglobulin A, α-lactalbumin, lactoferrin, hen egg white ly