Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Bridget M. Seitz"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The 5-HT7 receptor is the primary mediator of both the acute (
Externí odkaz:
https://doaj.org/article/ad92f7ad332e4ed38a185435d4dc2a1f
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
The purpose of this study was to investigate serial ultrasound imaging in rats as a fully non-invasive method to 1) quantify the diameters of splanchnic veins in real time as an indirect surrogate for the capacitance function of those veins, and 2) a
Externí odkaz:
https://doaj.org/article/4d07eeee11cb429180b5159d039f2d12
Publikováno v:
Experimental Physiology. 105:2025-2032
New findings What is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5-hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5-hydroxytryptami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79ee6a69c9693272e550efd89e05276
https://doi.org/10.1113/ep088919
https://doi.org/10.1113/ep088919
Autor:
Gregory D. Fink, Teresa Krieger-Burke, Stephanie W. Watts, Bridget M Seitz, Elena Y. Demireva, William M. Burke, Huirong Xie
Publikováno v:
Physiol Genomics
The fall in mean arterial pressure (MAP) after 24 h of 5-HT infusion is associated with a dilation of the portal vein (PV) and abdominal inferior vena cava (Ab IVC); all events were blocked by the selective 5-HT7 receptor antagonist SB269970. Few stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e245029a5d66d1d17bdf51b44b27be98
https://doi.org/10.1152/physiolgenomics.00031.2019
https://doi.org/10.1152/physiolgenomics.00031.2019
Publikováno v:
Exp Physiol
Low dose infusion of 5-hydroxytryptamine (5-HT) to rats causes both an acute and chronic fall in arterial blood pressure. The 5-HT(7) receptor subtype plays a critical part in the observed hypotension. Acute (minutes to hours) 5-HT infusion shows no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1824e6f8d0e61212551d8e18541a4aea
https://pubmed.ncbi.nlm.nih.gov/33052620
https://pubmed.ncbi.nlm.nih.gov/33052620
Autor:
Adam E. Mullick, Janice M. Thompson, David J. Ferland, Emma S. Darios, Bridget M Seitz, Steve T. Yeh, Stephanie W. Watts
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:212-218
Chemerin is an inflammatory adipokine positively associated with hypertension and obesity. The majority of chemerin derives from the liver and adipose tissue, however, their individual contributions to blood pressure are unknown. We began studying ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c3dc39889413e9e6508d71dc5b7f6
https://doi.org/10.1124/jpet.117.245456
https://doi.org/10.1124/jpet.117.245456
Autor:
Teresa Krieger-Burke, Gregory D. Fink, Stephanie W. Watts, Janice M. Thompson, Emma S. Darios, Hakan S. Orer, Bridget M Seitz
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H676-H686
Serotonin [5-hydroxytryptamine (5-HT)] causes relaxation of the isolated superior mesenteric vein, a splanchnic blood vessel, through activation of the 5-HT7 receptor. As part of studies designed to identify the mechanism(s) through which chronic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805faab505bf9a86b0684f850e556292
https://doi.org/10.1152/ajpheart.00165.2017
https://doi.org/10.1152/ajpheart.00165.2017
Publikováno v:
Hypertension. 74
Infusions of 5-HT into normotensive rats reduce blood pressure over a one week period. Pharmacological studies show the 5-HT 7 receptor is necessary for at least the initial (first 24 hours) hypotension. However, if serotonergic agonists are to be co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa0f35b7c4fd3895ddd5302aad46922
https://doi.org/10.1161/hyp.74.suppl_1.p3048
https://doi.org/10.1161/hyp.74.suppl_1.p3048
Autor:
Huirong Xie, Stephanie W. Watts, Emma D Flood, Elena Y. Demireva, Janice M. Thompson, Bridget M Seitz
Publikováno v:
Physiol Genomics
Using CRISPR-Cas9 technology, we created a 5-HT7 receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b134f65fffcf16a10ce98f1702807ac0
https://europepmc.org/articles/PMC6689730/
https://europepmc.org/articles/PMC6689730/
Publikováno v:
Hypertension. 72
Circulating 5-hydroxytryptamine (5-HT) regulates mean arterial pressure (MAP) under some conditions. Infusion of low doses of 5-HT into rats leads to a sustained decrease in MAP which is prevented by the selective 5-HT7 receptor (5-HT7R) antagonist S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d8efe34fbdaaee2dda0166bdd5051a
https://doi.org/10.1161/hyp.72.suppl_1.p212
https://doi.org/10.1161/hyp.72.suppl_1.p212