Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Bridget M. Lumb"'
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
IntroductionThe extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. The cerebellar medial nucleus (MCN) has bidirectional connections with the ventrol
Externí odkaz:
https://doaj.org/article/50215245b3534cfbb41f511e2d4cc85f
Autor:
Bridget M. Lumb, Lucy F. Donaldson
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Descending pain modulatory systems (DPMS) that originate within the brain and act to modulate spinal nociceptive transmission are a major determinant of the acute and chronic pain experience. Investigations of these systems in basic scientific resear
Externí odkaz:
https://doaj.org/article/3584bc4e569642aebbfc694b36509e49
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Externí odkaz:
https://doaj.org/article/97971c9ebcc54a498b84c69280d11d03
Autor:
Charlotte Lawrenson, Elena Paci, Jasmine Pickford, Robert AR Drake, Bridget M Lumb, Richard Apps
Publikováno v:
eLife, Vol 11 (2022)
The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the identification of neurons in male rat ventrolateral PAG (vlPAG) that encode fear memory through signalling the onset and offset of an auditory-conditioned stimulu
Externí odkaz:
https://doaj.org/article/1e22b6c1f71546089ae7ab6dbb018b2a
Publikováno v:
eLife, Vol 10 (2021)
The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to
Externí odkaz:
https://doaj.org/article/dc79eb2849f8474fbce593e75687617a
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Publikováno v:
Phelps, C E, Lumb, B M, Donaldson, L F & Robinson, E S J 2021, ' The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation ', PAIN, vol. 162, no. 3, pp. 956-966 . https://doi.org/10.1097/j.pain.0000000000002177
Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of interest in previously rewarding activities. Major depressive disorder is also associated with neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d1bb9345cbb74be94978df0f4ca1c1
https://research-information.bris.ac.uk/en/publications/3dedead5-ffc1-470d-9d93-f1e92ee77303
https://research-information.bris.ac.uk/en/publications/3dedead5-ffc1-470d-9d93-f1e92ee77303
Publikováno v:
eLife, Vol 10 (2021)
eLife
Drake, R A R, Lumb, B M, Apps, R & Pickering, A E 2021, ' Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats ', eLife, vol. 10, e65156, pp. 1-22 . https://doi.org/10.7554/eLife.65156
Drake, R A R, Apps, R, Pickering, A E & Lumb, B M 2021, ' Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats ', eLife, vol. 10, e65156, pp. 1-22 . https://doi.org/10.7554/eLife.65156
eLife
Drake, R A R, Lumb, B M, Apps, R & Pickering, A E 2021, ' Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats ', eLife, vol. 10, e65156, pp. 1-22 . https://doi.org/10.7554/eLife.65156
Drake, R A R, Apps, R, Pickering, A E & Lumb, B M 2021, ' Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats ', eLife, vol. 10, e65156, pp. 1-22 . https://doi.org/10.7554/eLife.65156
The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to