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pro vyhledávání: '"Bridget M. Barr"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:489-493
As part of an on-going effort to investigate the chemical space requirements for D(2)/5-HT(2A) receptor antagonists as atypical antipsychotics, new 1-aminoindanes were synthesized. The replacement of the heterocycle (oxindole) in ziprasidone with a c
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4560-4563
Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assa
Autor:
Leonard T. Meltzer, Sham S. Nikam, Jon L. Wright, Julie McCormick, Kevin A. Serpa, Brian Edward Kornberg, Bridget M. Barr, Suzanne Ross Kesten, Linda L. Coughenour
Publikováno v:
ChemInform. 35
A benzylpiperidine analogue with an acetylenic linker, 5-(3-[4-(4-fluorobenzyl)-piperidin-1-yl]-prop-1-ynyl)-1,3-dihydrobenzimidazol-2-one (3), was identified as a chemical lead with excellent activity at the NR1A/2B receptor (IC50=3 nM). Efforts to